1-Octanol reaction products with epichlorhydrin... - Registration Dossier
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EC number: 473-730-4 | CAS number: 928768-73-4
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient of the test material has been determined to be 4.51 x 10^3, Log 10 Pow 3.66 by the HPLC method. However, due to the surfactant properties of the test material, a computerbased estimation of partition coefficient may be more reliable. Using the referenced software above, a result of Log 10 Pow 2.47 was obtained.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.47
- at the temperature of:
- 20 °C
Additional information
Substances having a log 10 Pow greater than 3 are regarded as having the potential to bioaccumulate
in the environment.
Testing was carried out at approximately neutral pH due to the absence of any possible
dissociating functional groups present in the test material.
The test material was determined to be surface-active by definition of Method A5. The
determination of partition coefficient is generally considered not relevant for surface-active
materials. However, in this particular case, there was no significant evidence to suggest that the
determination was invalid.
There were no visible signs of interaction of the test material with the stationary phase of the
HPLC column, such as peak tailing etc, although interaction still could have occurred.
An investigation into the potential of the test material to emulsify in an n-octanol:water system
showed that no emulsification was observed and that the two immiscible phases separated. A trial
determination of partition coefficient using the shake-flask method yielded a result of
Log 10 Pow 3.08, which was within 1 log unit of the determined value by the HPLC method.
Additionally, an estimation of partition coefficient (Episuite version 3.1 1, June 10th 2003,
copyright US EPA 2000) by computer-based estimation software gave a result of Log 10 Pow 2.47,
again only differing from the determined value by approximately 1 log unit.
The test material has a structure resembling that of a typical surfactant and thus it is feasible that
the low result obtained in the surface tension test is due to the test material and not any impurities.
Therefore, taking the above into consideration it is possible that the experimentally determined
value of the partition coefficient is subject to error. However, there is no significant evidence
other than that the material has been determined surface active in the surface tension test to
suggest that the value of partition coefficient obtained is not reliable and valid.
The partition coefficient of the test material has been determined to be 4.51 x 10^3, Log 10 Pow 3.66
by the HPLC method. However, due to the surfactant properties of the test material, a computerbased
estimation of partition coefficient may be more reliable. Using the referenced software
above, a result of Log 10 Pow 2.47 was obtained.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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