Substance Information

Substance Infocard


Benzidine and its salts

EC / List no.: -

CAS no.: -

Mol. Formula:

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Key datasets


Regulatory context

Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):

REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation
  • REACH Annex XVII. Substances for which certain uses are Restricted under REACH at EU level.
CAD - Chemical Agents Directive
  • CAD - Chemical Agents Directive, Annex III - Prohibitions
    EU. Directive 98/24/EC, Annex III, Prohibitions, OJ (L 131) 11, 5 May 1998

    This list contains substances assigned a binding occupational exposure limit value (OELV) by the European Union. National OELVs for these substances may not deviate from the limits in the Directive. Annex III contains a list of prohibited substances and their concentration limit values in percent by weight.

Construction Products Regulation
  • Construction Product Regulation - Annex I (3) - Hazardous Substances
    EU. Hazardous Substances for Purposes of Annex I (3) (Requirements for Construction Works), Regulation 305/2011/EU on Marketing of Construction Products, amended by Regulation 574/2014/EU, 28 May 2014

    This list contains a non-exhaustive inventory of substances taken from: (1) Table 3 of Annex VI to CLP; (2) the Candidate List of SVHCs; (3) Annex XIV of REACH (Authorisation List); (4) Annex XVII of REACH (Restrictions List); (5) F-gases subject to emission limits/reporting per Regulation 517/2014/EU; and (6) volatile organic compounds (VOCs) listed in the Ambient Air Directive 2008/50/EC. The basis of the list is Annex I(3) of the Construction Products Regulation 305/2011/EC, which stipulates that construction works must not have a high impact on human health or the environment as a result of: giving off toxic gas; emissions of dangerous substances, volatile organic compounds (VOC), greenhouse gases or dangerous particles into indoor or outdoor air; release of dangerous substances into drinking water, ground water, marine waters, surface waters or soil.

General Product Safety Directive
  • General Product Safety Directive - Hazardous Substances
    EU. Hazardous Substances for Purposes of General Product Safety Directive (2001/95/EC), 15 January 2002, amended by Reg 596/2009/EC, 18 July 2009

    This list contains a non-exhaustive inventory of substances that fall within the European Union's hazardous substance definitions, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; (2) Annex III of Directive 2000/54/EC (Biological Agents); Candidate List of SVHCs; and REACH Annexes XIV and XVII (Authorisation and Restriction lists). They can be considered hazardous for purposes of the General Product Safety Directive 2001/95/EC.

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Substance names and other identifiers

Regulatory process names
Benzidine and its salts
Restriction list, Other
Benzidine and/or its derivatives
Construction Product Regulation - Annex I (3) - Hazardous Substances, General Product Safety Directive - Hazardous Substances
Salts of Benzidine
CAD - Chemical Agents Directive, Annex III - Prohibitions
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Group members

This entry / group of substance has the following member substances:

Results list is empty
Name EC / List no. CAS no. Association
Salts of benzidine - - Expert judgement (ECHA)
Benzidine 202-199-1 92-87-5 Expert judgement (ECHA)
Disodium 4,4'-diaminobiphenyl-2,2'-disulfonate - 27336-24-9 Expert judgement
1,1'-Biphenyl-4,4'-diamine, monoperchlorate - 29806-76-6 Expert judgement
Benzidine, hydrochloride - 14414-68-7 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, dihydriodide - 75534-79-1 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, monohydrochloride - 75752-15-7 Expert judgement
benzidine, mono(2-hydroxy-3,5-dinitrobenzoate) - 78577-03-4 Expert judgement
benzidine, mono(3,5-dinitrobenzoate) - 78577-08-9 Expert judgement
benzidine, bis(2-hydroxy-3,5-dinitrobenzoate) - 92415-34-4 Expert judgement
benzidine, bis(3,5-dinitrobenzoate) - 92415-52-6 Expert judgement
[1,1'-Biphenyl]-4,4'-diamine, perchlorate - 38668-12-1 Expert judgement
Benzidine diperchlorate - 41195-21-5 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, dihydrofluoride - 41766-73-8 Expert judgement
(1,1'-Biphenyl)-4,4'-diamine, monoacetate - 52754-64-0 Expert judgement
(1,1'-Biphenyl)-ar,ar',4,4'-tetramine - 66836-18-8 Expert judgement
benzidine, phosphate (1:1) - 66907-22-0 Expert judgement
Nickel(2+), ((1,1'-biphenyl)-4,4'-diamine-N)- - 67632-50-2 Expert judgement
Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate 217-710-3 1937-37-7 Expert judgement
Trisodium 5-amino-3-[[4'-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-2,7-disulphonate 219-384-8 2429-73-4 Expert judgement
Disodium 5-[[4'-[(1-amino-4-sulphonato-2-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-387-4 2429-79-0 Expert judgement
Tetrasodium 5-[[4'-[[2,6-diamino-3-[[8-hydroxy-3,6-disulphonato-7-[(4-sulphonato-1-naphthyl)azo]-2-naphthyl]azo]-5-tolyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-390-0 2429-81-4 Expert judgement
Disodium 5-[[4'-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-391-6 2429-82-5 Expert judgement
Disodium 4-amino-3-[[4'-[(2,4-diamino-5-methylphenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate 219-392-1 2429-83-6 Expert judgement
Disodium 5-[[4'-[(2-amino-8-hydroxy-6-sulphonato-1-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]salicylate 219-393-7 2429-84-7 Expert judgement
Tetrasodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] 220-012-1 2602-46-2 Expert judgement
Disodium 5-[[4'-[[2,4-dihydroxy-3-[(4-sulphonatophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 220-768-2 2893-80-3 Expert judgement
Disodium 5-[[4'-[[1-hydroxy-7-(phenylamino)-3-sulphonato-2-naphthyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 222-450-9 3476-90-2 Expert judgement
Disodium 8-[[4'-[(4-ethoxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-7-hydroxynaphthalene-1,3-disulphonate 222-560-7 3530-19-6 Expert judgement
Disodium 7-hydroxy-8-[[4'-[[4-[[(p-tolyl)sulphonyl]oxy]phenyl]azo][1,1'-biphenyl]-4-yl]azo]naphthalene-1,3-disulphonate 222-655-3 3567-65-5 Expert judgement
Disodium 4-amino-5-hydroxy-3-[[4'-[(4-hydroxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-6-(phenylazo)naphthalene-2,7-disulphonate 222-835-1 3626-28-6 Expert judgement
Benzidine sulphate 244-236-4 21136-70-9 Expert judgement
Disodium [5-[[4'-[[2,6-dihydroxy-3-[(2-hydroxy-5-sulphophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylato(4-)]cuprate(2-) 240-221-1 16071-86-6 Expert judgement
Disodium 5-[[4'-[[4,5-dihydro-3-methyl-5-oxo-1-(4-sulphonatophenyl)-1H-pyrazol-4-yl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 236-106-0 13164-93-7 Expert judgement
[2,2'-dichloro[1,1'-biphenyl]-4,4'-diyl]diammonium sulphate 274-338-4 70146-07-5 Expert judgement
Dipotassium O,O'-(4,4'-diaminobiphenyl-3,3'-ylene)diglycollate 277-771-7 74220-10-3 Expert judgement
Benzidine acetate 252-984-8 36341-27-2 Expert judgement
Tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] 200-786-7 72-57-1 Expert judgement
3,3'-dichlorobenzidine 202-109-0 91-94-1 Expert judgement
3,3'-dimethoxybenzidine 204-355-4 119-90-4 Expert judgement
4,4'-bi-o-toluidine 204-358-0 119-93-7 Expert judgement
Benzidine dihydrochloride 208-519-6 531-85-1 Expert judgement
[[1,1'-biphenyl]-4,4'-diyl]diammonium sulphate 208-520-1 531-86-2 Expert judgement
Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) 209-358-4 573-58-0 Expert judgement
4,4'-bi-o-toluidine dihydrochloride 210-322-5 612-82-8 Expert judgement
3,3'-dichlorobenzidine dihydrochloride 210-323-0 612-83-9 Expert judgement
Disodium 5-[[4'-[[2,4-diamino-5-[(4-sulphophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]salicylate 223-294-4 3811-71-0 Expert judgement
Disodium 4-amino-5-hydroxy-6-[[4'-[(4-hydroxyphenyl)azo][1,1'-biphenyl]-4-yl]azo]-3-[(4-nitrophenyl)azo]naphthalene-2,7-disulphonate 224-376-2 4335-09-5 Expert judgement
Trisodium 5-[[4'-[[8-amino-1-hydroxy-7-[(p-nitrophenyl)azo]-3,6-disulphonato-2-naphthyl]azo]-4-biphenyl]azo]salicylate 226-545-6 5422-17-3 Expert judgement
Disodium 5-[[4'-[[2,6-diamino-3-methyl-5-[(4-sulphonatophenyl)azo]phenyl]azo][1,1'-biphenyl]-4-yl]azo]-3-methylsalicylate 228-829-5 6360-54-9 Expert judgement
Hexasodium 5,5'-[(3,7-disulphonato-1,5-naphthylene)bis[azo(6-hydroxy-3,1-phenylene)azo[6(or 7)-sulphonato-4,1-naphthylene]azo[1,1'-biphenyl]-4,4'-diylazo]]bis(salicylate) 232-397-3 8014-91-3 Expert judgement
1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-7-((4'-((2-hydroxy-1-naphthalenyl)azo)-(1,1'-biph 613-540-2 6426-67-1 Expert judgement
2,[?]-Naphthalenedisulfonic acid, 4-[[][[]4-[[](4-amino-1-naphthalenyl)azo]-1-naphthalenyl]azo]-, disodium salt 616-837-5 8004-59-9 Expert judgement