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Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Alternatives to vertebrate testing

As of 11 September 2015 ECHA is inviting registrants that make testing proposals involving vertebrate animals for details on how they have considered alternative methods to address the missing information. This is a follow-up action of the European Ombudsman's conclusion in case 1606/2013 on 11 September 2015. A link to the registrant's considerations on alternatives to testing is published below with the related testing proposal. indicated The field is empty when the testing proposal was submitted before 11 September 2015 or when the registrant has not submitted a report on his considerations on alternatives to testing

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

15 resultaten.
 
1,4-Benzenedicarboxylic acid, mixed Bu and 2-ethylhexyl diesters 946-149-3 1571954-81-8
05/07/2018
05/07/2018
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Link
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-C12-14 acyl derivs., hydroxides, inner salts 293-878-1 91648-19-0
02/08/2018
02/08/2018
02/08/2018
Long-term toxicity to fish || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
Link
2-(2H-benzotriazol-2-yl)-p-cresol 219-470-5 2440-22-4 02/08/2018 Bioaccumulation aquatic / sediment Give Comments Link
4,4'-Isopropylidenediphenol, ethoxylated 500-082-2 -
05/07/2018
05/07/2018
05/07/2018
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Benzoic acid, 2-hydroxy-, mono-C>13-alkyl derivs., calcium salts (2:1) 281-018-8 83846-43-9 02/08/2018 Sub-chronic toxicity (90-day): oral Give Comments Link
branched-nonyl 3,5,5 trimethylhexanoate 701-133-3 - 05/07/2018 Sub-chronic toxicity (90-day): oral || Note: previous EC no 609-993-0 Give Comments Link
Bumetrizole 223-445-4 3896-11-5 02/08/2018 Bioaccumulation aquatic / sediment Give Comments Link
Dipotassium tetrachloroplatinate 233-050-9 10025-99-7 02/08/2018 Genetic toxicity in vivo || Note: "Testing proposal is based on concern identified by the registrant." Give Comments Link
Ethylene dibenzoate 202-338-6 94-49-5
05/07/2018
05/07/2018
Developmental neurotoxicity
Reproductive toxicity (pre-natal developmental toxicity 
Link
Isononanoic acid, C16-18 (even numbered)-alkyl esters 601-141-6 111937-03-2 02/08/2018 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments Link
Methanal, reaction products with 1,3-bis(aminomethyl)benzene and hydroxybenzen 701-207-5 1950616-36-0
05/07/2018
05/07/2018
05/07/2018
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Reaction mass of 1-[2-(2-aminobutoxy)ethoxy]but-2-ylamine and 1-({[2-(2-aminobutoxy)ethoxy]methyl}propoxy)but-2-ylamine 447-920-2 - 05/07/2018 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
Sodium 4-oxovalerate 243-378-4 19856-23-6
02/08/2018
02/08/2018
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Tetra(isobutyl)thioperoxydicarbamic acid 221-312-5 3064-73-1
02/08/2018
02/08/2018
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Zinc, bis[O,O-bis(1-methylethyl) phosphorodithioato-.kappa.S]bis(cyclohexanamine)-, (T-4)- 809-986-4 52585-16-7 02/08/2018 Genetic toxicity in vivo Give Comments Link
15 resultaten.



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