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Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Alternatives to vertebrate testing

As of 11 September 2015 ECHA is inviting registrants that make testing proposals involving vertebrate animals for details on how they have considered alternative methods to address the missing information. This is a follow-up action of the European Ombudsman's conclusion in case 1606/2013 on 11 September 2015. A link to the registrant's considerations on alternatives to testing is published below with the related testing proposal. indicated The field is empty when the testing proposal was submitted before 11 September 2015 or when the registrant has not submitted a report on his considerations on alternatives to testing

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

44 resultaten.
 
1-[(2-tert-butylcyclohexyl)oxy]butan-2-ol 412-300-2 - 05/04/2021 Reproductive toxicity (pre-natal developmental toxicity) Give Comments
1-Propanone, 2-hydroxy-2-methyl-, 1-(4-C10-13-alkylphenyl) derivs. 600-033-6 1001416-18-7 05/04/2021 Reproductive toxicity (pre-natal developmental toxicity) Give Comments
2-Propenoic acid, 1,1'-[(1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)]] ester, reaction products with diethylamine 601-101-8 111497-86-0 05/04/2021 Sub-chronic toxicity (90-day): oral Give Comments
3,3'-oxybis(ethyleneoxy)bis(propylamine) 224-207-2 4246-51-9
05/04/2021
05/04/2021
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco 500-303-2 115340-85-7 08/03/2021 Genetic toxicity in vivo Give Comments
4-hydroxybenzophenone 214-507-1 1137-42-4 05/04/2021 Genetic toxicity in vivo Give Comments
6-tert-butyl-2,4-xylenol 217-533-1 1879-09-0
05/04/2021
05/04/2021
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Adipic acid 204-673-3 124-04-9 05/04/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
Androst-4-ene-3,17-dione 200-554-5 63-05-8 08/03/2021 Long-term toxicity to fish Give Comments
cobalt carbonate 208-169-4 513-79-1
08/03/2021
08/03/2021
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2)
Cobalt dihydroxide 244-166-4 21041-93-0
08/03/2021
08/03/2021
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2)
cobalt dinitrate 233-402-1 10141-05-6
08/03/2021
08/03/2021
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2)
Cobalt oxide 215-154-6 1307-96-6
08/03/2021
08/03/2021
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2)
cobalt sulphate 233-334-2 10124-43-3
08/03/2021
08/03/2021
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo
Cobalt, borate neodecanoate complexes 270-601-2 68457-13-6 08/03/2021 Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) Give Comments
Dimethyl(propyl)amine 213-139-9 926-63-6
05/04/2021
05/04/2021
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Ethyldimethylamine (EC 209-940-8)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Ethyldimethylamine (EC 209-940-8)
Disodium 4-[4-[[5-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-2,5-dichlorobenzenesulphonate 274-499-0 70247-70-0 05/04/2021 Genetic toxicity in vivo Give Comments
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-[(4-methyl-3-sulphonatophenyl)sulphonyl]phenyl]azo]naphthalene-2-sulphonate 286-122-7 85187-33-3 05/04/2021 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant Give Comments
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate 274-437-2 70210-40-1 05/04/2021 Genetic toxicity in vivo Give Comments
Distillates (petroleum), full-range straight-run middle 272-341-5 68814-87-9 08/03/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Distillates (petroleum), heavy straight-run (EC 272-817-2) (CAS 68915-96-8) Give Comments
Fatty acids, C14-C18 and C18 unsaturated, amides with 2,2’-iminodiethanol 948-052-1 - 08/03/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-215-4 68475-94-5 05/04/2021 Genetic toxicity in vivo Give Comments
Hexadecane 208-878-9 544-76-3
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hexyl salicylate 228-408-6 6259-76-3
05/04/2021
05/04/2021
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
Hydrocarbons, C10-C13, aromatics, 922-153-0 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) 919-164-8 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C14-C19, isoalkanes, cyclics, <2% aromatics 920-114-2 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30 %) 919-006-8 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C7-C9, isoalkanes 921-728-3 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C9-C10, aromatics, >1% naphthalene 946-365-8 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Hydrocarbons, C9-C11, isoalkanes, cyclics 920-134-1 -
08/03/2021
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
m-xylene 203-576-3 108-38-3 05/04/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with p-xylene (EC 203-396-5) Give Comments
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine 264-761-2 64265-45-8 08/03/2021 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant Give Comments
Neodecanoic acid, cobalt salt 248-373-0 27253-31-2 08/03/2021 Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant Give Comments
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate 252-029-5 34443-12-4
08/03/2021
08/03/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
p-xylene 203-396-5 106-42-3 05/04/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
Reaction mass of propylidynetrimethanol and 2-ethylpropane-1,3-diol and 5-ethyl-1,3-dioxane-5-methanol 904-153-2 - 05/04/2021 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments
Reaction product of 2,4-Dinitrotoluene and 2,6-Dinitrotoluene and hydrogen 939-489-9 -
05/04/2021
05/04/2021
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Rectified Hydrocarbons by-products from synthetic process of Turpentine and acid, alcohols fraction 949-141-8 -
08/03/2021
08/03/2021
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Resin acids and Rosin acids, cobalt salts 273-321-9 68956-82-1 08/03/2021 Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) Give Comments
Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane 300-344-4 93925-42-9 08/03/2021 Genetic toxicity in vivo Give Comments
Stearic acid, cobalt salt 237-016-4 13586-84-0 08/03/2021 Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) Give Comments
tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4 05/04/2021 Genetic toxicity in vivo Give Comments
Trisodium 4-amino-5-hydroxy-3-[[4-[[2-oxo-1-[(phenylamino)carbonyl]propyl]azo]phenyl]azo]-6-[(4-sulphonato-1-naphthyl)azo]naphthalene-2,7-disulphonate 279-093-7 79135-92-5 08/03/2021 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. Give Comments
44 resultaten.



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