Predchádzajúce/výsledok

Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

There are currently no ongoing consultations.
 
Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) 298-577-9 93819-94-4
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Silver 231-131-3 7440-22-4 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with silver(1+) acetate (CAS number 563-63-3) 27/09/2017 13/11/2017 Details
Sodium p-cumenesulphonate 239-854-6 15763-76-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium (xylenes and 4-ethylbenzene) sulphonate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium cumene sulphonate
22/06/2017
22/06/2017
07/08/2017
07/08/2017
Details
potassium 4-cumenesulfonate 629-764-9 164524-02-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with sodium (xylenes and 4-ethylbenzene) sulphonate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium cumene sulphonate  
22/06/2017
22/06/2017
07/08/2017
07/08/2017
Details
Sodium toluene-4-sulphonate 211-522-5 657-84-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with sodium (xylenes and 4-ethylbenzene) sulphonate 
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium cumene sulphonate 
22/06/2017
22/06/2017
07/08/2017
07/08/2017
Details
sodium p-cumenesulphonate 239-854-6 15763-76-5 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium xylene sulphonate 24/04/2015 12/06/2015 Details
potassium 4-cumenesulfonate 629-764-9 164524-02-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium xylene sulphonate (EC 215-090-9) 16/12/2016 30/01/2017 Details
sodium toluene-4-sulphonate 211-522-5 657-84-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium xylene sulphonate (EC 215-090-9) 16/12/2016 30/01/2017 Details
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with structural analogues TETA (CAS 90640-67-8) and HEPA (CAS 68121-73-7).
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018
Details
Amines, polyethylenepoly-, tetraethylenepentamine fraction 292-587-7 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with TETA (CAS 90640-67-8) and HEPA (68121-73-7)
Reproductive toxicity (pre-natal developmental toxicity )
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Details
Triethoxy(vinyl)silane 201-081-7 78-08-0
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with trimethoxy(vinyl)silane (EC 220-449-8)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(vinyl)silane (EC 220-449-8)
23/04/2018
23/04/2018
07/06/2018
07/06/2018
Details
Hydrocarbons, C14-C17, n-alkanes, <2% aromatics 917-828-1 - Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a group: Icosane (EC 204-018-1) and Hydrocarbons, C14-C19, isoalkanes, cyclics, < 2% aromatics (920-114-2) 02/11/2018 17/12/2018 Details
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018 Details
Reaction mass of diisobutyl adipate and diisobutyl glutarate and diisobutyl succinate 907-870-9 -
Reproductive toxicity (extended one-generation reproductive toxicity study) ||Note: testing proposed with Reaction mass of dimethyl adipate and dimethyl glutarate and dimethyl succinate (EC 906-170-0 )
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Reaction mass of dimethyl adipate and dimethyl glutarate and dimethyl succinate (EC 906-170-0 )
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate 820-225-5 101747-77-7
Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
Details
Bis[C5-(branched)-alkyl]l benzene-1,4-dicarboxylate   940-272-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
01/09/2017
01/09/2017
01/09/2017
16/10/2017
16/10/2017
16/10/2017
Details
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate 425-220-8 5945-33-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/08/2021
26/08/2021
11/10/2021
11/10/2021
Details
(2E)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol 701-122-3 106185-75-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/10/2022
26/10/2022
12/12/2022
12/12/2022
Details
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromo-2-methylpropoxy)benzene] 306-832-3 97416-84-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/07/2021
01/07/2021
16/08/2021
16/08/2021
Details
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol 264-261-4 63469-23-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone 436-710-6 756-13-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/04/2021
22/04/2021
07/06/2021
07/06/2021
Details
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride 246-644-8 25134-21-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
03/11/2023
03/11/2023
18/12/2023
18/12/2023
Details
1,2-dimethylimidazole 217-101-2 1739-84-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
1,4-Benzenedicarboxylic acid, mixed Bu and 2-ethylhexyl diesters 946-149-3 1571954-81-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/05/2018
21/05/2018
05/07/2018
05/07/2018
Details
2,2-dimethyl-1,3-dioxolan-4-ylmethanol 202-888-7 100-79-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
Details
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
Details
2-methylpentane-2,4-diol 203-489-0 107-41-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/03/2018
26/03/2018
11/05/2018
11/05/2018
Details
3-(trimethoxysilyl)propylamine 237-511-5 13822-56-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
Details
3-aminopropyltriethoxysilane 213-048-4 919-30-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/03/2021
18/03/2021
03/05/2021
03/05/2021
Details
3-chloropropyltrimethoxysilane 219-787-9 2530-87-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/08/2021
26/08/2021
11/10/2021
11/10/2021
Details
4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane 260-350-7 56706-10-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/04/2018
23/04/2018
07/06/2018
07/06/2018
Details
4-hydroxy-4-methylpentan-2-one 204-626-7 123-42-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2016
01/09/2016
17/10/2016
17/10/2016
Details
4-morpholinecarbaldehyde 224-518-3 4394-85-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
8,9,10-trinorborn-2-ene 207-866-0 498-66-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/11/2015
01/11/2015
16/12/2015
16/12/2015
Details
Amides, C16-C18 (even) , N,N'-ethylenebis 931-299-4 68390-94-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/03/2023
01/03/2023
17/04/2023
17/04/2023
Details
Amines, polyethylenepoly-, triethylenetetramine fraction 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018


Details
Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
Details
Ashes (residues), plant 297-049-5 93333-79-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Details
ASPHALT 232-490-9 8052-42-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
31/05/2016
31/05/2016
15/07/2016
15/07/2016
Details
barium titanium trioxide 234-975-0 12047-27-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
17/04/2015
17/04/2015
04/06/2015
04/06/2015
Details
Benzene, diethenyl- and Benzene, ethenylethyl- 910-757-7 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
Details
Biphenyl-4,4'-diol 202-200-5 92-88-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
Details
Chloroethane 200-830-5 75-00-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/03/2017
10/03/2017
25/04/2017
25/04/2017
Details
cobalt dichloride 231-589-4 7646-79-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/07/2016
18/07/2016
01/09/2016
01/09/2016


Details
Ditolyl ether 248-948-6 28299-41-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/10/2021
21/10/2021
07/12/2021
07/12/2021
Details
Docosan-1-ol 211-546-6 661-19-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
30/06/2023
30/06/2023
14/08/2023
14/08/2023
Details
dodecamethylpentasiloxane 205-492-2 141-63-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
17/06/2020
17/06/2020
03/08/2020
03/08/2020
Details
Ethylene 200-815-3 74-85-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
30/09/2021
30/09/2021
15/11/2021
15/11/2021
Details
Ethylenediamine, propoxylated 500-035-6 25214-63-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
Details
hexadecyltrimethoxysilane 240-464-3 16415-12-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/11/2021
25/11/2021
10/01/2022
10/01/2022
Details
Hexamethylcyclotrisiloxane 208-765-4 541-05-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/10/2022
26/10/2022
12/12/2022
12/12/2022
Details
Hexan-6-olide 207-938-1 502-44-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/12/2020
16/12/2020
01/02/2021
01/02/2021
Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate 252-029-5 34443-12-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/01/2021
21/01/2021
08/03/2021
08/03/2021
Details
pentaerythritol 204-104-9 115-77-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
20/12/2017
20/12/2017
05/02/2018
05/02/2018
Details
Peracetic acid 201-186-8 79-21-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/08/2021
26/08/2021
11/10/2021
11/10/2021
Details
Phthalic anhydride 201-607-5 85-44-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/03/2021
18/03/2021
03/05/2021
03/05/2021
Details
Polysulfides, bis[3-(triethoxysilyl)propyl] 915-673-4 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2018
28/02/2018
16/04/2018
16/04/2018
Details
Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol 911-819-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
Details
Reaction mass of 3-isopropyl-6-methylenecyclohexene and (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene and (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexene 939-009-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
Reaction product of 2,4-Dinitrotoluene and 2,6-Dinitrotoluene and hydrogen 939-489-9 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2021
18/02/2021
05/04/2021
05/04/2021
Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid 931-291-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
Details
Sodium metavanadate 237-272-7 13718-26-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/01/2022
25/01/2022
11/03/2022
11/03/2022
Details
tert-dodecanethiol 246-619-1 25103-58-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/06/2017
22/06/2017
07/08/2017
07/08/2017
Details
tetrahydro-2-methylfuran 202-507-4 96-47-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Details
Tris(2-butoxyethyl) phosphate 201-122-9 78-51-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/03/2018
26/03/2018
11/05/2018
11/05/2018
Details
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate 250-418-4 30989-05-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
29/04/2016
29/04/2016
13/06/2016
13/06/2016
Details
undec-10-enoic acid 203-965-8 112-38-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
20/05/2021
20/05/2021
05/07/2021
05/07/2021
Details
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts 270-608-0 68457-79-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the substance, with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts 601-601-6 119345-04-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Details
2-hydroxy-2-methylpropiophenone 231-272-0 7473-98-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day)
21/10/2019
15/03/2011
15/03/2011
15/03/2011
05/12/2019
29/04/2011
29/04/2011
29/04/2011
Details
Distillates (petroleum), hydrodesulfurized middle 265-183-3 64742-80-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Details
Distillates (petroleum), hydrotreated middle 265-148-2 64742-46-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Details
Extracts (petroleum), deasphalted vacuum residue solvent 295-332-8 91995-70-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Details
Extracts (petroleum), residual oil solvent 265-110-5 64742-10-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Details
Gas oils (petroleum), hydrodesulfurized 265-182-8 64742-79-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Details
1,1'-methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol 701-041-3 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
16/06/2022
16/06/2022
16/06/2022
01/08/2022
01/08/2022
01/08/2022
Details
2-methylpropene 204-066-3 115-11-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
Hydrocarbons, C4, 1,3-butadiene- and isobutene-free 306-004-1 95465-89-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
1,4-diazabicyclooctane 205-999-9 280-57-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/10/2022
26/10/2022
26/10/2022
12/12/2022
12/12/2022
12/12/2022
Details
1-(2-hydroxyethyl)pyrrolidin-2-one 222-359-4 3445-11-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
16/12/2020
01/02/2021
01/02/2021
01/02/2021
Details
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-107-7 40039-93-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
Details
3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione 401-540-3 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/03/2018
26/03/2018
26/03/2018
11/05/2018
11/05/2018
11/05/2018
Details
4,4'-Isopropylidenediphenol, ethoxylated 500-082-2 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/05/2018
21/05/2018
21/05/2018
05/07/2018
05/07/2018
05/07/2018
Details
Benzyldimethylamine 203-149-1 103-83-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
23/03/2020
23/03/2020
23/03/2020
07/05/2020
07/05/2020
07/05/2020
Details
Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) 500-004-7 9003-29-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
C16-(branched), C20-(branched) and C24-(branched)-alkanes 700-992-1 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
28/02/2018
28/02/2018
28/02/2018
16/04/2018
16/04/2018
16/04/2018
Details
Di-tert-butyl trisulphide 224-226-6 4253-90-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/03/2023
01/03/2023
01/03/2023
17/04/2023
17/04/2023
17/04/2023
Details
Dibenzoyl peroxide 202-327-6 94-36-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
16/12/2020
01/02/2021
01/02/2021
01/02/2021
Details
Ethane- 1,2-diol, propoxylated 500-078-0 31923-84-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
05/07/2018
20/08/2018
20/08/2018
20/08/2018
Details
Fatty acids, C12-14 (even numbered), methyl ester 629-776-4 308065-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/09/2021
30/09/2021
30/09/2021
15/11/2021
15/11/2021
15/11/2021
Details
Hexadecane 208-878-9 544-76-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C10-C13, aromatics, 922-153-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) 919-164-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C14-C19, isoalkanes, cyclics, <2% aromatics 920-114-2 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30 %) 919-006-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C7-C9, isoalkanes 921-728-3 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C9-C10, aromatics, >1% naphthalene 946-365-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Hydrocarbons, C9-C11, isoalkanes, cyclics 920-134-1 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
Details
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol 246-771-9 25265-77-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
Details
Lithium bis(fluorosulfonyl)imide 686-526-7 171611-11-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/10/2021
21/10/2021
21/10/2021
07/12/2021
07/12/2021
07/12/2021
Details
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts 270-608-0 68457-79-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
Details
Pivalic acid 200-922-5 75-98-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
20/12/2017
20/12/2017
20/12/2017
05/02/2018
05/02/2018
05/02/2018
Details
Pleuromulin 204-747-5 125-65-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/09/2018
06/09/2018
06/09/2018
22/10/2018
22/10/2018
22/10/2018
Details
Polysulfides, di-tert-dodecyl 270-335-7 68425-15-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
31/01/2018
19/03/2018
19/03/2018
19/03/2018
Details
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane 608-489-8 30499-70-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
25/06/2015
10/08/2015
10/08/2015
10/08/2015
Details
Reaction mass of C18 (unsatd.) fatty acid amides/esters of diethanolamine, C16-18 (even-numbered) fatty amine (..) 943-172-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/05/2016
17/05/2016
17/05/2016
01/07/2016
01/07/2016
01/07/2016
Details
Reaction products of monoethanolamine and boric acid (1:3) 701-024-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
Triethoxyoctylsilane 220-941-2 2943-75-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- 907-495-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit
Sub-chronic toxicity (90 day): inhalation
27/05/2019
27/05/2019
27/05/2019
11/07/2019
11/07/2019
11/07/2019
Details
Propene 204-062-1 115-07-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with ethylene (EC no. 200-815-3)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
N-methylaniline 202-870-9 100-61-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90 day): dermal
23/04/2018
23/04/2018
07/06/2018
07/06/2018
Details
1,3-dimethylimidazolidin-2-one 201-304-8 80-73-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate 239-701-3 15625-89-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
25/05/2020
25/05/2020
09/07/2020
09/07/2020
Details
Carboxymethyldimethyl-3-[[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulphonyl]amino]propylammonium hydroxide 252-046-8 34455-29-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
01/02/2021
01/02/2021
Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
01/02/2021
01/02/2021
Details
Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- 500-012-0 9004-77-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1).
Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
Reaction products of monoethanolamine and boric acid (1:1) 701-025-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
COBALT DICHLORIDE 231-589-4 7646-79-9
Reproductive toxicity (extended one-generation reproductive toxicity study)

Reproductive toxicity (pre-natal developmental toxicity)
29/04/2016
29/04/2016
13/06/2016
13/06/2016
Details
4,4'-Methylenediphenyl diisocyanate, oligomers 500-040-3 25686-28-6 Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 16/06/2022 01/08/2022 Details
1,1'-Methylenebis(4-isocyanatobenzene) and 1,1'-methylenebis(4-isocyanatobenzene) homopolymer and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propane-1,2-diol 701-393-8 - Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 16/06/2022 01/08/2022 Details
Reaction mass of 4,4'-methylenediphenyl diisocyanate and o-(p-isocyanatobenzyl)phenyl isocyanate / methylene diphenyl diisocyanate 905-806-4 - Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 16/06/2022 01/08/2022 Details
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no: 202-966-0) 16/06/2022 01/08/2022 Details
1,1,1,3,3,3-hexamethyldisilazane 213-668-5 999-97-3
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1)
Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1)
16/06/2022
16/06/2022
01/08/2022
01/08/2022
Details
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8 Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) 23/03/2020 07/05/2020 Details
Divanadium pentaoxide 215-239-8 1314-62-1
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
Vanadium dioxide 234-841-1 12036-21-4
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: : testing proposed with Sodium metavanadate (EC no. 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)
16/06/2022
16/06/2022
01/08/2022
01/08/2022
Details
Sodium N-lauroylsarcosinate 205-281-5 137-16-6 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: Note: testing proposed with N-methyl-N-[C18-(unsaturated)alkanoyl]glycine (EC no. 701-177-3) 30/06/2023 14/08/2023 Details
N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine 229-761-9 6711-48-4 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with N,N-diethylpropane-1,3-diamine (EC no. 203-236-4) 22/09/2022 07/11/2022 Details
Ethylenediamine, propoxylated 500-035-6 25214-63-5
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 1,1',1'',1'''-ethylenedinitrilotetrapropan-2-ol (EC no. 203-041-4)
Reproductive toxicity (pre-natal developmental toxicity)
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
2-butene 203-452-9 107-01-7
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
But-1-ene 203-449-2 106-98-9
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
Butene 246-689-3 25167-67-3
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with 2-methylpropene (EC no. 204-066-3)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
4,4'-Methylenediphenyl diisocyanate, oligomeric reaction products with 2,4'-diisocyanatodiphenylmethane 500-297-1 109331-54-6 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 31/01/2023 17/03/2023 Details
4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide – nano form 220-509-3 2786-76-7 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with [3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide] (EC no. 229-440-3) 03/10/2023 17/11/2023 Details
Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction 293-263-8 91053-01-9
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
Dodecene, branched 306-479-5 97280-83-6
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
Extracts (petroleum), deasphalted vacuum residue solvent 295-332-8 91995-70-9 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Extracts (petroleum), residual oil solvent (EC no. 265-110-5) 06/06/2023 21/07/2023 Details
Petroleum diesel/gas oil fraction, co-processed with renewable hydrocarbons derived from thermally cracked plastics 941-803-4 -
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9) ||Note: testing proposed with Fuels, diesel (EC no. 269-822-7) ||Note: testing proposed with Fuel oil, no. 4 (EC no. 270-673-5) ||Note: testing proposed with Distillates (petroleum), light hydrocracked (EC no. 265-078-2)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9)
26/10/2022
26/10/2022
26/10/2022
12/12/2022
12/12/2022
12/12/2022
Details
Hydrocarbons, C4, steam-cracker distillate 295-405-4 92045-23-3
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1)
Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1)
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
Details
Xylene 215-535-7 1330-20-7 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC No 905-588-0) 01/03/2023 17/04/2023 Details
Xylene 215-535-7 1330-20-7 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC no. 905-588-0) 31/01/2023 17/03/2023 Details
Divanadium tris(sulphate) 237-226-6 13701-70-7
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)
30/06/2023
30/06/2023
14/08/2023
14/08/2023
Details
[[(phosphonomethyl)imino]bis[ethylenenitrilobis(methylene)]]tetrakisphosphonic acid, ammonium salt 274-798-6 70714-66-8 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Sodium salts of [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid (5-7 Na:1) (EC no. 701-216-4) 01/03/2023 17/04/2023 Details
2-methylpropane-2-thiol 200-890-2 75-66-1
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with tert-dodecanethiol (EC no. 246-619-1 )
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with tert-dodecanethiol (EC no. 246-619-1)
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
Bis(α,α-dimethylbenzyl) peroxide 201-279-3 80-43-3 Reproductive toxicity (pre-natal developmental toxicity 20/10/2016 05/12/2016 Details
2,2-bis(hydroxymethyl)propionic acid // 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid 225-306-3 -
Reproductive toxicity (pre-natal developmental toxicity study)
Sub-chronic oral toxicity (90-day): oral
05/04/2011
05/04/2011
20/05/2011
20/05/2011
Details
Resin acids and Rosin acids, calcium salts 232-694-8 9007-13-0
Reproductive toxicity (pre-natal developmental toxicity || Note: Testing proposed with Rosin CAS 8050-09-7
Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposed with Rosin CAS 8050-09-7
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin CAS 8050-09-7, Rosin hydrogenated CAS 65997-06-0, and Rosin reaction products with formaldehyde CAS 91081-53-7
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Details
Bis(trimethoxysilylpropyl)amine 280-084-5 82985-35-1
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
17/06/2020
17/06/2020
03/08/2020
03/08/2020
Details
Ditetradecyl peroxydicarbonate 258-436-4 53220-22-7
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Details
Poly(oxy-1,2-ethanediyl), .alpha.-[3-[(carboxymethyl)methylamino]-2-hydroxypropyl]-.omega.-(4-nonylphenoxy)-, monosodium sal 616-248-3 75627-31-5
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
23/12/2015
23/12/2015
03/02/2016
03/02/2016
Details
(-)-pin-2(3)-ene 232-077-3 7785-26-4 Reproductive toxicity (pre-natal developmental toxicity) 25/10/2017 11/12/2017 Details
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014 Details
(E)-N-(pentan-2-ylidene)hydroxylamine 484-470-6 623-40-5 Reproductive toxicity (pre-natal developmental toxicity) 18/03/2021 03/05/2021 Details
(ethoxymethoxy)cyclododecane 261-332-1 58567-11-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
(phenylethyl)benzene 254-179-7 38888-98-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014 Details
(Reaction product of 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol, 2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylated 926-000-9 - Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
(Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid 701-116-0 - Reproductive toxicity (pre-natal developmental toxicity) 23/03/2020 07/05/2020 Details
(Z)-N-octadec-9-enylhexadecan-1-amide 240-367-6 16260-09-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
1,1'-(methylenedi-p-phenylene)bismaleimide 237-163-4 13676-54-5 Reproductive toxicity (pre-natal developmental toxicity) 30/09/2021 15/11/2021 Details
1,1'-dithiobis[hexahydro-2H-azepin-2-one] 245-910-0 23847-08-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015 Details
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (pre-natal developmental toxicity) 31/07/2015 14/09/2015 Details
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate 244-894-2 22288-43-3 Reproductive toxicity (pre-natal developmental toxicity) 03/03/2014 17/04/2014 Details
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one 251-649-3 33704-61-9 Reproductive toxicity (pre-natal developmental toxicity) 30/06/2023 14/08/2023 Details
1,2,4-trimethylbenzene 202-436-9 95-63-6 Reproductive toxicity (pre-natal developmental toxicity) 03/10/2023 17/11/2023 Details
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters 701-339-3 - Reproductive toxicity (pre-natal developmental toxicity) 25/05/2020 09/07/2020 Details
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 213-834-7 1025-15-6 Reproductive toxicity (pre-natal developmental toxicity) 25/09/2012 12/11/2012 Details
1,3- and 1,4-cyclohexandicarboxyaldehyde 482-020-3 - Reproductive toxicity (pre-natal developmental toxicity) 15/07/2014 29/08/2014 Details
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone 255-460-7 41611-76-1 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
1,4-diazabicyclooctane 205-999-9 280-57-9 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
1-(2-hydroxyethyl)pyrrolidin-2-one 222-359-4 3445-11-2 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
1-[(2-tert-butylcyclohexyl)oxy]butan-2-ol 412-300-2 - Reproductive toxicity (pre-natal developmental toxicity) 18/02/2021 05/04/2021 Details
1-aminopropan-2-ol 201-162-7 78-96-6 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019 Details
1-chloro-2,3-dimethylbenzene 480-880-4 608-23-1 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018 Details
1-Dodecene, dimers 814-509-8 62132-67-6 Reproductive toxicity (pre-natal developmental toxicity) 02/11/2018 17/12/2018 Details
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate 229-934-9 6846-50-0 Reproductive toxicity (pre-natal developmental toxicity) 14/03/2016 28/04/2016 Details
1-Propanone, 2-hydroxy-2-methyl-, 1-(4-C10-13-alkylphenyl) derivs. 600-033-6 1001416-18-7 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2021 05/04/2021 Details
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019 Details
2,2'-dimethyl-2,2'-azodipropiononitrile 201-132-3 78-67-1 Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016 Details
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) 202-319-2 94-28-0 Reproductive toxicity (pre-natal developmental toxicity) 01/07/2021 16/08/2021 Details
2,2,2`,2`-Tetrakis(hydroxymethyl)-3,3`-oxydipropan-1-ol 204-794-1 126-58-9 Reproductive toxicity (pre-natal developmental toxicity) 15/03/2011 29/04/2011 Details
2,2,4-trimethylpentane-1,3-diol 205-619-1 144-19-4 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014 Details
2,2-Bis(hydroxymethyl)-1,3-propanediol (pentaerythritol) 204-104-9 115-77-5 Reproductive toxicity (pre-natal developmental toxicity) 15/03/2011 29/04/2011 Details
2,2-dimethylpropan-1-ol, tribromo derivative 253-057-0 36483-57-5 Reproductive toxicity (pre-natal developmental toxicity) 17/04/2015 04/06/2015 Details
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016 Details
2,4,6-tri-tert-butylphenol 211-989-5 732-26-3 Reproductive toxicity (pre-natal developmental toxicity) 01/07/2021 16/08/2021 Details
2,4-dimethyl-6-(1-methyl-pentadecyl)phenol 411-220-5 - Reproductive toxicity (pre-natal developmental toxicity) 25/09/2012 12/11/2012 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 26/08/2021 11/10/2021 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 29/07/2011 12/09/2011 Details
2,6-di-tert-butylphenol 204-884-0 128-39-2 Reproductive toxicity (pre-natal developmental toxicity) 17/06/2020 03/08/2020 Details
2,6-dimethyloct-7-en-2-ol 242-362-4 18479-58-8 Reproductive toxicity (pre-natal developmental toxicity) 26/08/2021 11/10/2021 Details
2-(2-(2-butoxyethoxy)ethoxy)ethanol 205-592-6 143-22-6 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018 Details
2-(2-methoxyethoxy)ethanol 203-906-6 111-77-3 Reproductive toxicity (pre-natal developmental toxicity) 21/10/2019 05/12/2019 Details
2-(dimethylamino)-2-methylpropan-1-ol 230-279-6 7005-47-2 Reproductive toxicity (pre-natal developmental toxicity) 31/01/2014 17/03/2014 Details
2-benzofuran-1,3-dione; 2-(2-hydroxyethoxy)ethanol 608-744-3 32472-85-8 Reproductive toxicity (pre-natal developmental toxicity) 16/03/2015 30/04/2015 Details
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone 404-360-3 - Reproductive toxicity (pre-natal developmental toxicity) 24/05/2013 08/07/2013 Details
2-isocyanatoethyl methacrylate 250-284-7 30674-80-7 Reproductive toxicity (pre-natal developmental toxicity) 23/03/2020 07/05/2020 Details
2-mercaptoethanol 200-464-6 60-24-2 Reproductive toxicity (pre-natal developmental toxicity) 15/04/2011 30/05/2011 Details
2-Oxepanone, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol 500-099-5 37625-56-2 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2011 29/08/2011 Details