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EC number: 203-458-1
CAS number: 107-06-2
Dominant lethal screening:
Statistically significant effects in the ratio of dead to
live fetuses were observed in both generations. However, these effects,
which were both increases and decreases compared to controls, did not
appear to be dose related.
Maternal ingestion of the test compound produced no
apparent adverse reproductive effects or increased incidence of fetal
visceral or skeletal anomalies.
A multigeneration reproduction study was modified to
include screening for lethal and teratogenic effects of 1,2
-dichloroethane in drinking solution (Emulphor: deionized water, 1:99,
v/v). Male and female (10 and 30/dose level, respectively) ICR Swiss
mice received 1,2 -dichloroethane at concentrations of 0, 0.03, 0.09 or
0.29 mg/mL. These concentrations were designed to yield daily doses of
0, 5, 15 or 50 mg/kg bw/d. No taste aversion was evident. There appeared
to be no dose-dependent effects on fertility, gestation, viability, or
lactation indices. Pup survival and weight gain were not adversely
affected. 1,2 -dichlororethane failed to produce significant dominant
lethal mutations or terata in either of the two generations tested.
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