Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-458-1
CAS number: 107-06-2
Dominant lethal screening:
Statistically significant effects in the ratio of dead to
live fetuses were observed in both generations. However, these effects,
which were both increases and decreases compared to controls, did not
appear to be dose related.
Maternal ingestion of the test compound produced no
apparent adverse reproductive effects or increased incidence of fetal
visceral or skeletal anomalies.
A multigeneration reproduction study was modified to
include screening for lethal and teratogenic effects of 1,2
-dichloroethane in drinking solution (Emulphor: deionized water, 1:99,
v/v). Male and female (10 and 30/dose level, respectively) ICR Swiss
mice received 1,2 -dichloroethane at concentrations of 0, 0.03, 0.09 or
0.29 mg/mL. These concentrations were designed to yield daily doses of
0, 5, 15 or 50 mg/kg bw/d. No taste aversion was evident. There appeared
to be no dose-dependent effects on fertility, gestation, viability, or
lactation indices. Pup survival and weight gain were not adversely
affected. 1,2 -dichlororethane failed to produce significant dominant
lethal mutations or terata in either of the two generations tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again