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EC number: 203-458-1
CAS number: 107-06-2
In an acute dermal toxicity study, groups of male
rabbits (6 -11 animals/dose level) were dermally exposed to 1,2 -dichloroethane
at doses of 3972, 5000, 5594 or 6285 mg/kg bw and observed for 14 days. Mortality
was observed in 2/6 at 3972 mg/kg bw within 5 -10 days, 3/11 at 5000
mg/kg bw within 1 -5 days, 8/9 at 5594 mg/kg bw within 1 -11 days and
5/6 at 6285 mg/kg bw within 1 day. Weight loss was reported in most
survivors. Gross necropsy evaluation revealed no adverse effects. The calculated
LD50 by the method of probits was 3.89 mL/kg bw (3.40 -4.46 mL/kg bw) or
4890 mg/kg bw (4270–5600 mg/kg bw).
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