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EC number: 203-458-1 | CAS number: 107-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1948
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: SIDS Initial Assessment Report
- Title:
- Mellon Inst. Industr. Research. The Toxicity of Ethylene Dichloride. 1948 in OECD SIDS report 1,2-dichloroethane
- Author:
- Anonymous
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report for 14th SIAM (Paris, France, March 2002)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichloroethane
- EC Number:
- 203-458-1
- EC Name:
- 1,2-dichloroethane
- Cas Number:
- 107-06-2
- Molecular formula:
- C2H4Cl2
- IUPAC Name:
- 1,2-dichloroethane
- Details on test material:
- 1,2-dichloroethane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no details given
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- Occluded applications : 3.16, 3.98, 4.45 and 5.0 mL/kg for 24 h (= 3972, 5000, 5594 and 6285 mg/kg bw)
- No. of animals per sex per dose:
- 6-11 animals
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- Probit analysis
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 890 mg/kg bw
- 95% CL:
- 4 270 - 5 600
- Mortality:
- Mortality observed within 14 days:
2/6 animals at 3972 mg/kg bw within 5-10 days
3/11 animals at 5000 mg/kg bw within 1-5 days
8/9 animals at 5594 mg/kg bw within 1-11 days
5/6 animals at 6285 mg/kg bw within 1 day
The LD50 calculated using the method of probits was 3.89 mL/kg bw (3.40-4.46 mL/kg bw) or 4890 mg/kg bw (4270-5600 mg/kg bw). - Clinical signs:
- other: No data
- Gross pathology:
- Gross necropsy evaluation revealed no adverse effects.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Acute dermal toxicity to male rabbits:
The calculated LD50 by the method of probits was 3.89 mL/kg bw (3.40-4.46 mL/kg bw) or 4890 mg/kg bw (4270-5600 mg/kg bw). - Executive summary:
In an acute dermal toxicity study, groups of male rabbits (6 -11 animals/dose level) were dermally exposed to 1,2 -dichloroethane at doses of 3972, 5000, 5594 or 6285 mg/kg bw and observed for 14 days. Mortality was observed in 2/6 at 3972 mg/kg bw within 5 -10 days, 3/11 at 5000 mg/kg bw within 1 -5 days, 8/9 at 5594 mg/kg bw within 1 -11 days and 5/6 at 6285 mg/kg bw within 1 day. Weight loss was reported in most survivors. Gross necropsy evaluation revealed no adverse effects. The calculated LD50 by the method of probits was 3.89 mL/kg bw (3.40 -4.46 mL/kg bw) or 4890 mg/kg bw (4270–5600 mg/kg bw).
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