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EC number: 203-458-1
CAS number: 107-06-2
In an acute dermal toxicity study, groups of
male rabbits (6 -11 animals/dose level) were dermally exposed to 1,2
-dichloroethane at doses of 3972, 5000, 5594 or 6285 mg/kg bw and
observed for 14 days. Mortality was observed in 2/6 at 3972 mg/kg bw
within 5 -10 days, 3/11 at 5000 mg/kg bw within 1 -5 days, 8/9 at 5594
mg/kg bw within 1 -11 days and 5/6 at 6285 mg/kg bw within 1 day. Weight
loss was reported in most survivors. Gross necropsy evaluation revealed
no adverse effects. The calculated LD50 by the method of probits was
3.89 mL/kg bw (3.40 -4.46 mL/kg bw) or 4890 mg/kg bw (4270–5600 mg/kg
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