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EC number: 203-458-1
CAS number: 107-06-2
In an acute oral toxicity study, groups of fasted (18 hours),
6 -week-old CD-1 mice were given a single oral dose of 1,2 -dichloroethane
and observed for 14 days.
The mice died over a 48 -hour period. Those surviving 48 hours
recovered and appeared normal at the end of the 14 -days observation
period. Macroscopically, target organs appeared to be liver and lungs. The
calculated LD50 values using log probit analysis were 489 mg/kg bw (95%
C.I. 424 -552 mg/kg bw) and 413 mg/kg bw (95% C.I. 337-499 mg/kg bw) for male
and female mice, respectively.
1,2 -dichloroethane is of low acute oral toxicity based on
the LD50 in male and female CD-1 mice.
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