Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-458-1
CAS number: 107-06-2
In a primary eye irritation study, 0.1 mL of
undiluted 1,2-dichloroethane was instilled into the conjunctival sac of
new Zealand rabbits (6 females). Eyes were not rinsed. Animals then were
observed for 14 days. Irritation was scored by the method of Draize.
After instillation, moderate lacrimation, mild-moderate catarrhal
conjunctivitis and corneal epithelium abrasion were visible in the slit
lamp using fluorescein. On day 7 after instillation, keratitis was still
evident, but regenerating, and fully disappeared after another 7 days.
The reversible effects were graded as "mild" with an overall irritation
index of 7 (of max. 110 scores). Under the conditions of this study, 1,2
-dichloroethane was a mild eye irritant in rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again