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EC number: 203-458-1
CAS number: 107-06-2
In a primary eye irritation study, 0.1 mL of
undiluted 1,2-dichloroethane was instilled into the conjunctival sac of
New Zealand rabbits (6 animals/dose). Eyes were not rinsed after application.
Animals then were observed for 4 -7 days. Irritation was scored by the
method of Draize.
After the application, slight reddening and
annular conjunctival swelling were noted in 2/6 and 1/6 animals, respectively.
All symptoms disappeared completely within three days. No rankings for
findings were given. However, the minor effects noted suggested no
irritation potential. Nevertheless, the substance was expected to have
an eye irritation potential (classified GHS Cat. 2 according to
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