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EC number: 203-458-1
CAS number: 107-06-2
The 4-h LC50 corresponded to approx. 1886 ppm (approx.
7758.5 mg/m³) and was derived from the data by Standard Probit analysis
(please refer to "Seuils de Toxicité aiguë 1,2-Dichloroéthane from
Groupe d’Experts Toxicologues du Ministère de l’Ecologie, de l’Energie,
du Développement Durable et de l’Aménagement du Territoire" dated
With 22000 ppm (approx. 90420 mg/m³), death occurred
within 24 min after deep anaesthesia by depression of the central
nervous system. At 12000 ppm and lower concentrations this depressant
action resulted in varying degrees of "drunkenness".
In special groups of animals (exposure causing 99.9, 50
or 0.01 % death), reported signs of exposure mediated toxicity were
decreased body weights, increased liver and kidney weights and slight
parenchymatous degeneration to severe haemorrhagic necrosis (kidney,
liver, adrenals), congestion (kidney, liver, adrenals, lungs) and oedema
(kidney, lungs), increase in blood urea nitrogen concentration, plasma
prothrombin clotting time, liver lipids, decrease in serum phospatase
The following concentrations and exposure times were not
300 ppm (approx. 1200 mg/m³) after 7 h (20 animals)
600 ppm (approx. 2400 mg/m³) after 5 h (20 animals)
1500 ppm (approx. 6100 mg/m³) after 2 h (10 animals)
3000 ppm (approx. 12100 mg/m³) after 0.5 h (22 animals)
20000 ppm (approx. 81000 mg/m³) after 0.1 h (10 animals)
The following concentrations were void of adverse
200 ppm (approx. 800 mg/m³) for 7 h
300 ppm (approx. 1200 mg/m³) for 3 h (but effects at 5.5
1000 ppm (approx 4000 mg/m³) for 1.5 h (but effects at 3
In an acute inhalation toxicity study,
groups of young adult albino rats (10-54/dose, approximately equal
numbers of males and females) were whole body exposed to 1,2
-dichloroethane for 0.1 to 8 hours at concentrations of 200, 300, 600,
800, 1000, 1500, 3000, 12000 or 20000 ppm (corresponding to 823, 1234,
2468, 3290, 4113, 6169, 12339, 49354 and 82256 mg/m³). Animals then were
observed for 2 to 3 weeks. At 20000 ppm, death occurred within 24 min
after deep anaesthesia by depression of the central nervous system. At
12000 ppm and lower concentrations this depressant action resulted in
varying degrees of "drunkenness". According to authors, deaths tended to
occur at three different time intervals and in such a manner as to
suggest three separate toxic actions of fatal degree:
1. At very high concentrations (e.g. 20000
ppm), deaths occurred due to depression and paralysis of CNS functions.
2. At all vapour concentrations causing
death, a large proportion died rather suddenly and quietly a few hours
after termination of exposure, showing marked cyanosis, reduced body
temperature, stupor or coma and failing respiration. The character and
sudden development of this response suggested "shock" or cardiovascular
3. All other deaths occurred delayed over a
period of 2 to 7 days with progressive loss of body weight and other
evidence of toxic effects, suggesting organ failure, probably due to
The 4 -h LC50 derived by Standard Probit
analysis in this acute inhalation study in rats was 1886 ppm (approx.
1,2 -dichloroethane is of low acute oral
toxicity based on the LC50 (4 hours) in male and female albino rats.
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