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EC number: 203-458-1
CAS number: 107-06-2
The acute toxicity of 1,2-dichloroethane to Daphnia magna was determined in a 48-hour test. Based on the results the 48-hour EC50 was determined to be 155 mg/L based on measured concentration. The 24–hr-acute toxicity of 1,2-dichlorethane to Artemia salina was studied under static conditions. The 24–hour EC50 was 320 mg test item/L.
Several invertebrates have been tested for
sensitivity to 1,2-dichlorethane.
The acute toxicity of 1,2-dichloroethane to
unfed Daphnia magna, was determined in an unaerated, static, 48-hour
test. Treatments consisted of a water control and the measured
concentrations of 70.4, 99.2, 137, 188, 250, 405 mg/L. Based on the
results the 48-hour EC50 was determined to be 155 mg/L based on measured
concentration. This study is classified as acceptable and satisfies the
guideline requirements for an acute toxicity study with freshwater
The 24–hr-acute toxicity of
1,2-dichlorethane to Artemia salina was studied under static conditions.
Shrimps were exposed to control and test chemical for 24 hr.
Immobilization and sublethal effects were observed at test termination.
The 24– hour EC50 was 320 mg test item/L.
Further studies on marine invertebrates like
Foster et al. 1984 and 1985 indicates an higher hazard, however, these
studies do not satisfy the guideline requirements, as the amount of
solvent (acetone) used in the test was variable in the different
concentrations and higher than the requested 0.1 mL/L. In addition,
non-physiological water salinities were used as further stressor.
The following additional information on
acute toxicity to Daphnia and other aquatic invertebrates is available:
LeBlanc, G.A. (1980)
150 mg/L (24 h)
Freitag, D. et al. (1994)
320 mg/L (24 h)
Price, K.S. et al. (1974)
113 mg/L (96 h)
Syracuse Res. Corp. (1978)
540 mg/L (24 h)
Bringmann, G. & Kuehn, R. (1982)
600 mg/L (24 h)
Knie, J. et al. (1983)
Kuehn, R. et al. (1989)
1350 mg/L (24 h)
Bringmann, G. & Kuehn, R. (1977)
> 100 mg/L (96 h)
Mayer, F.L. Fr. & Ellersieck, M.R. (1986)
94 mg/L (24 h)
Foster, G.D. & Tullis, R.E. (1984)
36.4 mg/L (24 h)
Foster, G.D. & Tullis, R.E. (1985)
Pearson, C.R. & McConnell, G. (1975)
170 mg/L (24 h)
Rosenberg, R. (1975)
20 % change of growth rate at 0.25 mg/L
Kerster, H.W. & Schaeffer, D.J. (1983)
Bringmann, G. & Kuehn, R. (1982): Z. Wasser
Abwasser Forsch. 15, 1 - 6.
Bringmann, G. & Kuehn, R. (1977): Results of
the damaging effect of water pollutants on Daphnia magna; Z. Wasser
Abwasser Forsch. 10, 161-166.
Foster, G.D. & Tullis, R.E. (1984): A
quantitative|structure-activity relationship between
partition|coefficients and the acute toxicity of naphthalene|derivatives
in artemia salina nauplii. Aquat. Toxicol. 5,|245-254.
Foster, G.D., Tullis, R.E. (1985):
Quantitativestructure-toxicity relationships with osmotically stressed
artemia salina nauplii; Environm. Pollution (Series A):38, 273-281.
Freitag, D., Ballhorn, L., Behechti, A.,
Fisher, K. & Thumm, W. (1994): Structural configuration and toxicity of
chlorinated alkanes; Chemosphere 282: 253-259.
Kerster, H.W. & Schaeffer, D.J. (1983):
Brine shrimp (artemia salina nauplii) as a teratogen test system;
Ecotoxicol. Environ. Safety 7, 342-349.
Knie, J., Haelke, A., Juhnke, I., Schiller,
W. (1983): Ergebnisse der Untersuchungen von chemischen Stoffen mit vier
Biotests; Dtsch. Gewaesserkundl. Mitt. 27(3), 77-79.
Kuehn, R., Pattard, M., Pernak, K.D. (1989):
Results of the harmful effects of selected water pollutants (anilines,
phenols, aliphatic compounds) to daphnia magna; Water Res. 23, 495-499.
LeBlanc, G.A. (1980): Acute toxicity of
priority pollutants to water flea (Daphnia magna); Bull. Environ.
Contam. Toxicol. 24, 684 - 691.
Mayer, F.L. Fr. & Ellersieck, M.R. (1986):
Manual of acute toxicity: interpretation and data base for 410 chemicals
and|66 species of freshwater animals; United States Department of the
Interior Fish and Wildlife Service/Publication 160, Washington, D.C., -
117, 30-32, 216.
Pearson, C.R. & McConnell, G. (1975):
Chlorinated C1 and C2|hydrocarbons in the marine environment. Proc. R.
Soc.|London, Ser. B. 189 (1096), 305-332.
Price, K.S., Waggy, G.T. & Conway, R.A.
(1974): Brine shrimp bioassay and seawater BOD of petrochemicals; J.
Water Pollut. Control. Fed. 46, 63-77.
Rosenberg R., Grahn, O., Johansson, L.
(1975): Toxic effects of aliphatic chlorinated by-products from vinyl
chloride production on marine animals; Water Res., 9(7), 607-12.
Syracuse Res. Corp. (1978): NTIS/OTS 0511060
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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