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EC number: 203-458-1
CAS number: 107-06-2
Carcinogenicity and chronic toxicity of 1,2-
dichloroethane were examined by inhalation exposure of groups of 50 F344/sex/dose
to 1,2- dichloroethane vapor or clean air as control for 6 h/d, 5 d/wk
and 104 wk. The rats were exposed to 0, 10, 40 or 160 ppm (v/v) (
equivalent to 0, 41.1, 164.5 or 658.1 mg/m³) 1,2- dichloroethane.
The 2-year exposure produced a dose-dependent increase in incidences of
benign and malignant tumors, including subcutaneous fibroma, mammary
gland fibroadenoma and peritoneal mesothelioma in male rats;
subcutaneous fibroma and mammary gland adenoma, fibroadenoma and
adenocarcinoma in female rats. No exposure-related change in the
incidence of non-neoplastic lesions or in any haematological, blood
biochemical or urinary parameter occurred in any exposed rat group. The
types of tumors and their target organs found in this study were
consistent with those observed in rats and mice administered 1,2 -
dichloroethane by gavage in a NCI study. Selection of the exposure
concentrations was considered appropriate with reference to the maximum
tolerated dose for the highest doses and an occupational exposure limit
of 1,2- dichloroethane for the lowest dose.
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