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EC number: 203-458-1
CAS number: 107-06-2
Male and female Sprague-Dawley rats (10 rats/sex/group)
received 1,2 -dichloroethane in corn oil by oral gavage (1 mL/kg bw) for
10 or 90 consecutive days. The doses for the 10-day study were 0, 10,
30,100, or 300 mg/kg bw/d; the 90 -day study doses were 0, 37.5, 75, and
150 mg/kg bw/d. Concurrent control animals were treated with the
vehicle, corn oil, only.
In the 10-day study, 10/10 female animals and 8/10 male
animals died in the high dose group. No further incidences of mortality
were observed. Final body weights and body weight gain along with
haematology and clinical chemistry findings were not different from
controls. The only relative organ weight which was significantly
different was the liver weight in males exposed to 100 mg/kg bw/d. The
main histopathological lesion exhibited was multifocal to diffuse
inflammation of the mucosal and submucosal layers of the forestomach in
the 100 mg/kg bw/d dose group. This change was minimal in both males and
In the 90-day study, there were no treatment-related
effects pertaining to clinical observations. Body weight gain and total
food consumption were significantly decreased in high dose males. There
were slight but significant differences in haemoglobin, haematocrit, red
blood cell count, platelets, albumin, and alkaline phosphatase values in
the 75 and/or 150 mg/kg bw/d groups in one or both sexes as compared to
concurrent controls. In males, relative brain, kidney, and liver weights
were significantly increased at 75 and 150 mg/kg bw/d. There were also
differences in spleen, adrenal, and testes weights (absolute and/or body
weight relative). In females, absolute and/or relative kidney and liver
weights were significantly increased at 150 mg/kg bw/d (liver) and at 75
and 150 mg/kg bw/d (kidney). There were no apparent treatment-related
effects pertaining to mortality, ophthalmology, gross pathology, or
Based on these results, a NOAEL of 37.5 mg/kg bw/d was
established for male and female Sprague-Dawley rats in the 90-day oral
(gavage) toxicity study.
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