Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
dodecamethylpentasiloxane | 205-492-2 | 141-63-9 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Decamethyltetrasiloxane (EC 205-491-7). |
25/06/2015 | 10/08/2015 | Details | |
trichloro(hexadecyl)silane | 227-575-2 | 5894-60-0 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6) Sub-chronic toxicity (90-day): oral Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
triethoxy(phenyl)silane | 212-305-8 | 780-69-8 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1) |
25/06/2015 | 10/08/2015 | Details | |
Strontium neodecanoate | 812-724-1 | 106705-37-7 | Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [Strontium oxide] (EC 215-219-9) | 26/04/2019 | 10/06/2019 | Details | |
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 254-996-9 | 40601-76-1 | Reproductive toxicity (pre-natal developmental toxicity) with Rat | 24/07/2019 | 09/09/2019 | Details | |
Sodium diisobutyldithiophosphinate | 236-419-2 | 13360-78-6 |
Reproductive toxicity (pre-natal developmental toxicity) with Rat Sub-chronic toxicity (90-day): oral |
24/07/2019 24/07/2019 |
09/09/2019 09/09/2019 |
Details | |
Hexamethyldisiloxane | 203-492-7 | 107-46-0 | Reproductive toxicity (pre-natal developmental toxicity) with the rabbit via inhalation | 25/06/2019 | 09/08/2019 | Details | |
1,4-Cyclohexanedimethanol, reaction products with epichlorohydrin | 600-447-7 | 1035218-79-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated Sub-chronic toxicity (90 day): inhalation || Note: Link to registration dossier not given as the dossier not yet disseminated |
23/12/2015 23/12/2015 |
03/02/2016 03/02/2016 |
Details | |
Reaction products of acrylic acid with 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] | 830-217-3 | 1393932-71-2 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated |
24/01/2019 24/01/2019 |
11/03/2019 11/03/2019 |
Details | |
Dihexadecyl peroxodicarbonate | 247-611-0 | 26322-14-5 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Name of the substance on which testing is proposed to be carried out: ditetradecyl peroxydicarbonate (EC: 258-436-4) Sub-chronic toxicity (90-day): oral |
23/04/2018 23/04/2018 |
07/06/2018 07/06/2018 |
Details | |
Residues (petroleum), hydrodesulfurized vacuum | 265-188-0 | 64742-85-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: test proposed with a liquid condensate collected from the headspace of a heated tank of Residues (petroleum), thermal cracked vacuum (CAS No 92062-05-0) Reproductive toxicity (two-generation reproductive toxicity) || Note: test proposed with a liquid condensate collected from the headspace of a heated tank of Residues (petroleum), thermal cracked vacuum (CAS No 92062-05-0) |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
Reaction mass of methyl dihydrogen phosphate and orthophosphoric acid and dimethyl hydrogen phosphate | 908-996-7 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1). Sub-chronic toxicity (90-day): oral || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1). |
20/05/2015 20/05/2015 |
06/07/2015 06/07/2015 |
Details | |
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid | 252-156-6 | 34690-00-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90-day): oral || Note: Testing proposal is based on concern identified by the registrant. |
20/05/2015 20/05/2015 |
06/07/2015 06/07/2015 |
Details | |
Reaction mass of [[(2-hydroxyethyl)imino]dimethylene]bisphosphonic acid, sodium salt and 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane, sodium salt | 939-513-8 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance Sub-chronic toxicity (90-day): oral Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed on rabbit. Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs. | 308-208-6 | 97925-95-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed on rabbits | 14/08/2014 | 28/09/2014 | Details | |
Resin acids and Rosin acids, Me esters | 269-035-9 | 68186-14-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
(3-chloropropyl)diethoxymethylsilane | 236-828-6 | 13501-76-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3) | 17/04/2015 | 04/06/2015 | Details | |
sodium 1H-benzotriazolide | 239-269-6 | 15217-42-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1H-Benzotriazole (EC 202-394-1) | 16/12/2016 | 30/01/2017 | Details | |
Nonanoic acid (branched), 2-oxiranylmethyl ester | 940-029-4 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2) Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2) |
20/09/2013 20/09/2013 20/09/2013 |
04/11/2013 04/11/2013 04/11/2013 |
Details | |
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 10/08/2018 | 24/09/2018 | Details | |
2-Oxepanone, polymer with 1,6-hexanediol | 609-271-5 | 36609-29-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
2,2,6,6-tetramethyl-4-oxopiperidinooxy | 220-778-7 | 2896-70-0 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2) Sub-chronic toxicity (90-day): oral || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2) |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
Pyridine, alkyl derivs. | 269-929-9 | 68391-11-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 5-ethyl-2-methylpyridine | 04/04/2014 | 19/05/2014 | Details | |
4-phenylbutan-2-one | 219-847-4 | 2550-26-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons | 22/11/2017 | 08/01/2018 | Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid | 500-090-6 | 36425-16-8 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral || Note: testing proposed with a structurally related substance (small vinyl ester) |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
(octadecanoato-O)oxoaluminium | 236-521-7 | 13419-15-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) | 30/11/2015 | 14/01/2016 | Details | |
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine | 264-761-2 | 64265-45-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
ethyl methyl carbonate | 433-480-9 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with an analogue substance. Sub-chronic toxicity (90-day): oral || Note: testing proposed with an analogue substance. |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Bismuth trinitrate | 233-791-8 | 10361-44-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8) Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8) |
20/09/2013 20/09/2013 |
04/11/2013 04/11/2013 |
Details | |
bismuth citrate | 212-390-1 | 813-93-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
Trimethyl borate | 204-468-9 | 121-43-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with boric acid. Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with boric acid. Sub-chronic toxicity (90-day): oral || Note: testing proposed with boric acid. |
15/04/2014 15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 30/05/2014 |
Details | |
Sodium hydrogen N-(1-oxododecyl)-L-glutamate | 249-958-3 | 29923-31-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with CAS 68187-30-4 | 16/05/2014 | 30/06/2014 | Details | |
1,4-diisopropylbenzene | 202-826-9 | 100-18-5 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with CAS no. 99-62-7 Sub-chronic toxicity (90-day): oral || Note: testing proposed with CAS no. 99-62-7 |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
diammonium hexanitratocerate | 240-827-6 | 16774-21-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Cerium (III) nitrate (CAS 10294-41-4) | 20/05/2015 | 06/07/2015 | Details | |
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane | 241-867-7 | 17928-28-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) | 12/12/2014 | 26/01/2015 | Details | |
dichloro(diphenyl)silane | 201-251-0 | 80-10-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9) Sub-chronic toxicity (90-day): oral Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
methyl-1h-benzotriazole | 249-596-6 | 29385-43-1 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with either Benzotriazole, Tolyltriazole, Sodium Benzotriazolate, or Sodium Tolyltriazolate | 16/12/2016 | 30/01/2017 | Details | |
Sodium 4(or 5)-methyl-1H-benzotriazolide | 265-004-9 | 64665-57-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with either Benzotriazole, Tolyltriazole, Sodium Benzotriazolate, or Sodium Tolyltriazolate | 16/12/2016 | 30/01/2017 | Details | |
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid | 252-156-6 | 34690-00-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP Sub-chronic toxicity (90-day): oral || Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP |
31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 |
Details | |
Reaction mass of ethoxylated (≥ 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate | 939-702-5 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Ethoxylated bisphenol A diacrylate Sub-chronic toxicity (90-day): oral || Note: testing proposed with Ethoxylated bisphenol A diacrylate |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
Fatty acids, C18-unsatd., dimers, polymers with oleic acid and triethylenetetramine | 614-339-2 | 68154-62-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) Sub-chronic toxicity (90-day): oral || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
Fatty acids, C18-unsatd., dimers, polymers with oleic acid and triethylenetetramine | 701-120-2 | - |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines | 614-452-7 | 68410-23-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Octene | 246-920-8 | 25377-83-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with hex-1-ene Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
orthoboric acid, compound with 2,2'-iminodiethanol | 267-886-0 | 67952-33-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with MEA Polyborate Sub-chronic toxicity (90-day): oral || Note: testing proposed with MEA Polyborate |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
Alkane-alpha,omega-diyl bis{[(trimethoxysilyl)propyl]carbamate}_M2 | 700-904-1 | 1350725-68-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl [3-(trimethoxysilyl) propyl]carbamate CAS 23432-62-4 | 02/11/2018 | 17/12/2018 | Details | |
Nitroethane | 201-188-9 | 79-24-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with nitromethane (EC 200-876-6) | 10/03/2017 | 25/04/2017 | Details | |
Phosphoric acid, mixed esters with Bu alc. and ethylene glycol | 284-716-0 | 84962-20-9 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 |
20/05/2015 20/05/2015 |
06/07/2015 06/07/2015 |
Details | |
Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) | 259-048-8 | 54261-67-5 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
|
Details |