Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
Orthoboric acid, compound with 2-aminoethanol | 247-421-8 | 26038-87-9 | Repeated dose toxicity (90-day): oral | 17/11/2011 | 02/01/2012 | Details | |
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate | 247-161-5 | 25646-71-3 | Genetic toxicity in vivo | 17/06/2020 | 03/08/2020 | Details | |
Dodecene | 246-922-9 | 25378-22-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 |
Details | |
Octene | 246-920-8 | 25377-83-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with hex-1-ene Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
Tridecene | 246-919-2 | 25377-82-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 |
Details | |
Decene | 246-870-7 | 25339-53-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 25/06/2012 |
15/07/2011 15/07/2011 09/08/2012 |
Details | |
2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/09/2017 | 16/10/2017 | Details | |
2,2`-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
Tetrapropylenebenzene | 246-772-4 | 25265-78-5 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | 25265-77-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 22/09/2022 | 07/11/2022 | Details | |
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | 25265-77-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/04/2019 26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 10/06/2019 |
Details | |
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | 25265-77-4 | Reproductive toxicity (pre-natal developmental toxicity) | 16/06/2011 | 01/08/2011 | Details | |
Hexene | 246-768-2 | 25264-93-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Hex-1-ene (EC 209-753-1)
|| Note: testing proposed with Octadec-1-ene (EC 112-88-9)
|| Note: testing proposed with Hexadecene (EC 248-131-4)
|| Note: testing proposed with Alkenes, C8-10, C9-rich (EC 271-212-0)
|| Note: testing proposed with Nonene, branched (EC 306-492-6) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Hex-1-ene (EC 209-753-1)
|| Note: testing proposed with Octadec-1-ene (EC 112-88-9)
|| Note: testing proposed with Octadecene (EC 248-205-6)
|| Note: testing proposed with Alkenes, C8-10, C9-rich (EC 271-212-0)
|| Note: testing proposed with Nonene, branched (EC 306-492-6) |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
2,4,4-trimethylpentene | 246-690-9 | 25167-70-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 15/07/2022 | 29/08/2022 | Details | |
2,4,4-trimethylpentene | 246-690-9 | 25167-70-8 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: There are two testing proposals for this endpoint. Sub-chronic toxicity (90-day): oral |
26/03/2018 26/03/2018 |
11/05/2018 11/05/2018 |
Details | |
Butene | 246-689-3 | 25167-67-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with 2-methylpropene (EC no. 204-066-3) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/05/2019 | 11/07/2019 | Details | |
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/03/2012 06/03/2012 06/03/2012 |
20/04/2012 20/04/2012 20/04/2012 |
Details | |
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
Trixylyl phosphate | 246-677-8 | 25155-23-1 | Bioaccumulation aquatic / sediment | 02/09/2011 | 17/10/2011 | Details | |
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride | 246-644-8 | 25134-21-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
03/11/2023 03/11/2023 |
18/12/2023 18/12/2023 |
Details | |
tert-dodecanethiol | 246-619-1 | 25103-58-6 | Long-term toxicity to fish | 16/06/2022 | 01/08/2022 | Details | |
tert-dodecanethiol | 246-619-1 | 25103-58-6 | Sub-chronic toxicity (90 day): inhalation | 14/11/2013 | 30/12/2013 | Details | |
tert-dodecanethiol | 246-619-1 | 25103-58-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/06/2017 22/06/2017 |
07/08/2017 07/08/2017 |
Details | |
Triethoxy(3-isocyanatopropyl)silane | 246-467-6 | 24801-88-5 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
triethoxy(3-isocyanatopropyl)silane | 246-467-6 | 24801-88-5 | Genetic toxicity in vivo Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9) | 03/02/2016 | 21/03/2016 | Details | |
Zinc bis(benzenesulphinate) | 246-148-1 | 24308-84-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide | 246-058-2 | 24170-60-3 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
1,1'-dithiobis[hexahydro-2H-azepin-2-one] | 245-910-0 | 23847-08-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
[3-(trimethoxysilyl)propyl]urea | 245-904-8 | 23843-64-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Urea, N-(3-silylpropyl)-, Si-(ethoxy and methoxy) derivs., (EC 601-461-6) || Note: Testing proposal is based on concern identified by the registrant | 07/07/2020 | 21/08/2020 | Details | |
3,6,9,12-tetraoxotridecanol | 245-883-5 | 23783-42-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1) | 21/10/2021 | 07/12/2021 | Details | |
[3-(triethoxysilyl)propyl]urea | 245-876-7 | 23779-32-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 |
Details | |
Methyl [3-(trimethoxysilyl)propyl]carbamate | 245-659-7 | 23432-62-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/03/2017 10/03/2017 10/03/2017 |
25/04/2017 25/04/2017 25/04/2017 |
Details | |
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine | 245-642-4 | 23410-40-4 |
Reproductive toxicity (pre-natal developmental toxicity) Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) Sub-chronic toxicity (90-day): oral Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] | 245-509-0 | 23235-61-2 | Sub-chronic toxicity (90-day): oral | 30/09/2015 | 16/11/2015 | Details | |
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] | 245-509-0 | 23235-61-2 | Long-term toxicity to fish | 15/01/2024 | 29/02/2024 | Details | |
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] | 245-509-0 | 23235-61-2 | Reproductive toxicity (developmental toxicity) | 26/01/2011 | 14/03/2011 | Details | |
2,2'-[OXYBIS(METHYLENE)]BIS[2-ETHYLPROPANE-1,3-DIOL] | 245-509-0 | 23235-61-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2016 29/04/2016 |
13/06/2016 13/06/2016 |
Details | |
2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] | 245-509-0 | 23235-61-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
Tetraammonium ethylenediaminetetraacetate | 245-022-3 | 22473-78-5 | Sub-chronic toxicity (90 day): inhalation | 16/06/2011 | 01/08/2011 | Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Reproductive toxicity (pre-natal developmental toxicity) | 03/03/2014 | 17/04/2014 | Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] | 244-617-5 | 21850-44-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
tin monoxide | 244-499-5 | 21651-19-4 | Sub-chronic toxicity (90 day): inhalation | 23/01/2015 | 09/03/2015 | Details | |
6-(cyclohexylamino)-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione | 244-320-0 | 21295-57-8 | Genetic toxicity in vivo | 26/08/2021 | 11/10/2021 | Details | |
2-[(2-methyl-1-oxoallyl)oxy]ethyl acetoacetate | 244-311-1 | 21282-97-3 | Genetic toxicity in vivo | 29/04/2014 | 13/06/2014 | Details | |
2-tert-butyl-1,4-dimethoxybenzene | 244-216-5 | 21112-37-8 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
Cobalt dihydroxide | 244-166-4 | 21041-93-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
Cobalt dihydroxide | 244-166-4 | 21041-93-0 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4) Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2) |
21/01/2021 21/01/2021 |
08/03/2021 08/03/2021 |
Details | |
Diammonium dihydrogen ethylenediaminetetraacetate | 244-063-4 | 20824-56-0 | Sub-chronic toxicity (90 day): inhalation | 29/07/2011 | 12/09/2011 | Details | |