Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene | 801-941-7 | 1404190-37-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/10/2016 20/10/2016 |
05/12/2016 05/12/2016 |
Details | |
((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene | 801-941-7 | 1404190-37-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
(-)-pin-2(3)-ene | 232-077-3 | 7785-26-4 | Reproductive toxicity (pre-natal developmental toxicity) | 25/10/2017 | 11/12/2017 | Details | |
(1,4-diazabicyclo[2.2.2]octane-2-yl)methanol | 692-731-2 | 76950-43-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 |
Details | |
(1-hydroxycyclohexyl) (phenyl)methanone (hydroxycyclohexyl phenyl ketone) | 213-426-9 | 947-19-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
28/02/2011 28/02/2011 28/02/2011 |
14/04/2011 14/04/2011 14/04/2011 |
Details | |
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate | 425-220-8 | 5945-33-5 | Reproductive toxicity (two-generation reproductive toxicity) | 05/04/2011 | 20/05/2011 | Details | |
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate | 425-220-8 | 5945-33-5 | Sub-chronic toxicity (90-day): oral | 01/09/2010 | 15/10/2010 | Details | |
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate | 425-220-8 | 5945-33-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 |
Details | |
(1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol | 695-878-0 | 1283129-18-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl triacrylate | 254-843-6 | 40220-08-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
(2-ethyl-2-methyl-1,3-dioxolan-4-yl)methyl prop-2-enoate | 807-159-2 | 69701-99-1 | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
(2E)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol | 701-122-3 | 106185-75-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 |
Details | |
(3-chloropropyl)diethoxymethylsilane | 236-828-6 | 13501-76-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3) | 17/04/2015 | 04/06/2015 | Details | |
(3-chloropropyl)dimethoxymethylsilane | 242-056-0 | 18171-19-2 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
(3-chloropropyl)dimethoxymethylsilane | 242-056-0 | 18171-19-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6)” | 17/04/2015 | 04/06/2015 | Details | |
(3-chloropropyl)triethoxysilane | 225-805-6 | 5089-70-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 |
Details | |
(3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde | 801-656-8 | 1416808-92-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/04/2015 | 04/06/2015 | Details | |
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate | 266-380-7 | 66492-51-1 | Reproductive toxicity (pre-natal developmental toxicity) | 21/03/2014 | 05/05/2014 | Details | |
(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 261-491-7 | 58909-56-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/08/2018 10/08/2018 10/08/2018 |
24/09/2018 24/09/2018 24/09/2018 |
Details | |
(chloromethyl)triethoxysilane | 239-311-3 | 15267-95-5 | Genetic toxicity in vivo | 16/10/2014 | 01/12/2014 | Details | |
(E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene | 807-113-1 | 3709-71-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
(E)-2-benzylideneoctanal | 639-566-4 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
(E)-7,11-dimethyl-3-methylenedodeca-1,6,10-triene | 242-582-0 | 18794-84-8 | Sub-chronic toxicity (90-day): oral | 23/04/2018 | 07/06/2018 | Details | |
(E)-N-(pentan-2-ylidene)hydroxylamine | 484-470-6 | 623-40-5 | Reproductive toxicity (pre-natal developmental toxicity) | 18/03/2021 | 03/05/2021 | Details | |
(ethoxymethoxy)cyclododecane | 261-332-1 | 58567-11-6 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |
(octadecanoato-O)oxoaluminium | 236-521-7 | 13419-15-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) | 30/11/2015 | 14/01/2016 | Details | |
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate | 255-901-3 | 42594-17-2 |
Bioaccumulation test (Bioconcentration: Flow-through Fish Test) Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate | 255-901-3 | 42594-17-2 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
22/04/2021 22/04/2021 22/04/2021 |
07/06/2021 07/06/2021 07/06/2021 |
Details | |
(octahydro-4,7-methano-1H-indenyl)methyl acrylate | 300-723-4 | 93962-84-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
(phenylethyl)benzene | 254-179-7 | 38888-98-1 | Reproductive toxicity (pre-natal developmental toxicity) | 21/03/2014 | 05/05/2014 | Details | |
(R)-p-mentha-1,8-diene | 227-813-5 | 5989-27-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
(Reaction product of 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol, 2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylated | 926-000-9 | - | Reproductive toxicity (pre-natal developmental toxicity) | 04/04/2014 | 19/05/2014 | Details | |
(Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid | 701-116-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
(Z)-4-[C11-13(branched)alkylamino]-4-oxo-2-butenoic acid | 701-116-0 | 84583-68-6 | Sub-chronic toxicity (90-day): oral || Note: The previous EC number for the substance is 283-219-6. | 22/06/2017 | 07/08/2017 | Details | |
(Z)-N-octadec-9-enylhexadecan-1-amide | 240-367-6 | 16260-09-6 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |
1,1'-(1,1,2,2-tetramethylethylene)dibenzene | 217-568-2 | 1889-67-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] | 284-366-9 | 84852-53-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/02/2020 | 09/04/2020 | Details | |
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromo-2-methylpropoxy)benzene] | 306-832-3 | 97416-84-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/07/2021 01/07/2021 |
16/08/2021 16/08/2021 |
Details | |
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] | 244-617-5 | 21850-44-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
1,1'-(methylenedi-p-phenylene)bismaleimide | 237-163-4 | 13676-54-5 | Reproductive toxicity (pre-natal developmental toxicity) | 30/09/2021 | 15/11/2021 | Details | |
1,1'-(p-tolylimino)dipropan-2-ol | 254-075-1 | 38668-48-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/03/2016 17/04/2015 |
28/04/2016 04/06/2015 |
Details | |
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol | 264-261-4 | 63469-23-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol | 264-261-4 | 63469-23-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/09/2022 22/09/2022 |
07/11/2022 07/11/2022 |
Details | |
1,1'-[oxybis(ethyleneoxy)]diethylene | 212-133-3 | 764-99-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/03/2023 01/03/2023 |
17/04/2023 17/04/2023 |
Details | |
1,1'-dithiobis[hexahydro-2H-azepin-2-one] | 245-910-0 | 23847-08-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | 116-37-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/01/2012 16/01/2012 16/01/2012 |
01/03/2012 01/03/2012 01/03/2012 |
Details | |
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | 116-37-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/07/2015 | 14/09/2015 | Details | |
1,1'-Methylenebis(4-isocyanatobenzene) and 1,1'-methylenebis(4-isocyanatobenzene) homopolymer and their reaction products with [(methylethylene)bis(oxy)]dipropanol and butane-1,3-diol and propane-1,2-diol | 701-393-8 | - | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 16/06/2022 | 01/08/2022 | Details | |
1,1'-Methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with [(methylethylene)bis(oxy)]dipropanol | 701-124-4 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
1,1'-methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with butane-1,3-diol, 2,2'-oxydiethanol and propane-1,2-diol | 701-173-1 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
1,1'-methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol | 701-041-3 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone | 436-710-6 | 756-13-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/04/2021 22/04/2021 |
07/06/2021 07/06/2021 |
Details | |
1,1,1,3,3,3-hexamethyldisilazane | 213-668-5 | 999-97-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane | 241-867-7 | 17928-28-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) | 12/12/2014 | 26/01/2015 | Details | |
1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane | 241-881-3 | 17955-88-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 |
Details | |
1,1,1,3,5,5,5-heptamethyltrisiloxane | 217-496-1 | 1873-88-7 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7 Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1,3,3-tetramethyl-1,3-divinyldisiloxane | 220-099-6 | 2627-95-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Reproductive toxicity (pre-natal developmental toxicity) | 03/03/2014 | 17/04/2014 | Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
1,1,3,3-tetramethylbutyl hydroperoxide | 227-369-2 | 5809-08-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
1,1,3,3-tetramethylbutyl peroxyneodecanoate | 257-077-0 | 51240-95-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
1,1,3,3-tetramethylbutyl peroxyneodecanoate | 257-077-0 | 51240-95-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant | 01/09/2017 | 16/10/2017 | Details | |
1,1,3,3-tetramethyldisiloxane | 221-906-4 | 3277-26-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
29/04/2016 29/04/2016 |
13/06/2016 13/06/2016 |
Details | |
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) | 235-935-5 | 13052-09-0 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 12/12/2014 | 26/01/2015 | Details | |
1,10-decanediyl diacrylate | 235-922-4 | 13048-34-5 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene | 228-846-8 | 6362-80-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (two-generation reproductive toxicity) | 16/06/2011 | 01/08/2011 | Details | |
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one | 251-649-3 | 33704-61-9 | Reproductive toxicity (pre-natal developmental toxicity) | 30/06/2023 | 14/08/2023 | Details | |
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride | 246-644-8 | 25134-21-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
03/11/2023 03/11/2023 |
18/12/2023 18/12/2023 |
Details | |
1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives | - | - | Sub-chronic toxicity (90-day): oral | 30/06/2016 | 15/08/2016 | Details | |
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters | 290-754-9 | 90218-76-1 | Sub-chronic toxicity (90-day): oral | 29/07/2011 | 12/09/2011 | Details | |
1,2,4-trimethylbenzene | 202-436-9 | 95-63-6 | Reproductive toxicity (pre-natal developmental toxicity) | 03/10/2023 | 17/11/2023 | Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 701-339-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 271-082-5 | 68515-40-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 |
Details | |
1,2-diacetoxybut-3-ene | 421-720-5 | 18085-02-4 | Sub-chronic toxicity (90-day): oral | 25/11/2021 | 10/01/2022 | Details | |
1,2-dihydroxybenzene,pyrocatechol | 204-427-5 | 120-80-9 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether | 282-199-6 | 84144-79-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 18/03/2021 | 03/05/2021 | Details | |
1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine | 259-393-4 | 54914-37-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 213-834-7 | 1025-15-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/09/2012 | 12/11/2012 | Details | |
1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt | 241-749-5 | 17766-26-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 257-913-4 | 52434-90-9 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/04/2023 03/04/2023 03/04/2023 |
22/05/2023 22/05/2023 22/05/2023 |
Details | |
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) | 219-514-3 | 2451-62-9 | Reproductive toxicity (two-generation reproductive toxicity) | 19/11/2010 | 03/01/2011 | Details | |
1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 247-465-8 | 26115-70-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/10/2023 03/10/2023 |
17/11/2023 17/11/2023 |
Details | |
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 254-996-9 | 40601-76-1 | Reproductive toxicity (pre-natal developmental toxicity) with Rat | 24/07/2019 | 09/09/2019 | Details | |
1,3- and 1,4-cyclohexandicarboxyaldehyde | 482-020-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2014 | 29/08/2014 | Details | |
1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates | 282-617-7 | 84281-74-3 | Genetic toxicity in vivo | 25/11/2021 | 10/01/2022 | Details | |
1,3-Benzenedimethanamine, N-(2-phenylethyl) derivs. | 445-790-1 | - | Sub-chronic toxicity (90 day): inhalation | 04/04/2014 | 19/05/2014 | Details | |
1,3-bis(isocyanatomethyl)benzene | 222-852-4 | 3634-83-1 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
1,3-Butanediol, reaction products with 1,1'-methylenebis[4-isocyanatobenzene], propylene glycol and tripropylene glycol | 941-496-7 | 1689576-89-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
1,3-diethyldiphenylurea | 201-645-2 | 85-98-3 | Sub-chronic toxicity (90-day): oral | 03/03/2014 | 17/04/2014 | Details | |
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione | 258-904-8 | 53988-10-6 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3) Reproductive toxicity (two-generation reproductive toxicity)
Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt | 262-872-0 | 61617-00-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
1,3-diisopropylbenzene | 202-773-1 | 99-62-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
1,3-dimethylimidazolidin-2-one | 201-304-8 | 80-73-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
1,3-dimethylimidazolidin-2-one | 201-304-8 | 80-73-9 | Reproductive toxicity (two-generation reproductive toxicity) | 15/04/2014 | 30/05/2014 | Details | |