Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Showing 1,151 - 1,200 of 2,011 results.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
1,1,3,3-tetramethyldisiloxane	221-906-4	3277-26-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	29/04/2016 29/04/2016	13/06/2016 13/06/2016	Details
Propylidynetrimethyl trimethacrylate	221-950-4	3290-92-4	Reproductive toxicity (pre-natal developmental toxicity)	31/05/2016	15/07/2016	Details
Propylidynetrimethyl trimethacrylate	221-950-4	3290-92-4	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/04/2019	10/06/2019	Details
N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine	251-459-0	33329-35-0	Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with structurally-related compound	29/04/2014	13/06/2014	Details
sodium O,O-diethyl dithiophosphate \|\| Note: testing proposed with sodium O,O-diisobutyl dithiophosphate (EC 258-508-5)	222-079-2	3338-24-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
Diisononyl adipate	251-646-7	33703-08-1	Long-term toxicity to fish\|\|Note: Read across testing proposed with Bis(2-ethylhexyl) adipate (EC no. 203-090-1) Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: Read across testing proposed with Bis(2-ethylhexyl) adipate (EC no. 203-090-1)	03/05/2023 03/05/2023	19/06/2023 19/06/2023	Details
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one	251-649-3	33704-61-9	Reproductive toxicity (pre-natal developmental toxicity)	30/06/2023	14/08/2023	Details
Perfluamine	206-420-2	338-83-0	Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	29/03/2019 29/03/2019 29/03/2019 29/03/2019	13/05/2019 13/05/2019 13/05/2019 13/05/2019	Details
Perfluamine	206-420-2	338-83-0	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Sodium hexahydroxoantimonate	251-735-0	33908-66-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011	29/08/2011 29/08/2011	Details
3-Ethenyl-5-methyl-2-oxazolidinone	809-852-5	3395-98-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	27/09/2017 27/09/2017	13/11/2017 13/11/2017	Details
Oleic acid, compound with (Z)-N-octadec-9-enylpropane-1,3-diamine (2:1)	251-846-4	34140-91-5	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
tert-pentyl hydroperoxide	222-321-7	3425-61-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	07/10/2016 07/10/2016	21/11/2016 21/11/2016	Details
tert-pentyl hydroperoxide	222-321-7	3425-61-4	Genetic toxicity in vivo	21/03/2014	05/05/2014	Details
Bisisobutyryl peroxide	222-340-0	3437-84-1	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	04/04/2014 04/04/2014 04/04/2014	19/05/2014 19/05/2014 19/05/2014	Details
trimethoxy(2,4,4-trimethylpentyl)silane	251-995-5	34396-03-7	Sub-chronic toxicity (90-day): oral Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) "	25/06/2015	10/08/2015	Details
trimethoxy(2,4,4-trimethylpentyl)silane	251-995-5	34396-03-7	Long-term toxicity to fish	26/10/2022	12/12/2022	Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate	252-029-5	34443-12-4	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	21/01/2021 21/01/2021	08/03/2021 08/03/2021	Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate	252-029-5	34443-12-4	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/03/2014 21/03/2014 21/03/2014	05/05/2014 05/05/2014 05/05/2014	Details
1-(2-hydroxyethyl)pyrrolidin-2-one	222-359-4	3445-11-2	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020 16/12/2020	01/02/2021 01/02/2021 01/02/2021	Details
1-(2-hydroxyethyl)pyrrolidin-2-one	222-359-4	3445-11-2	Reproductive toxicity (pre-natal developmental toxicity)	14/08/2014	28/09/2014	Details
Carboxymethyldimethyl-3-[[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulphonyl]amino]propylammonium hydroxide	252-046-8	34455-29-3	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
Carboxymethyldimethyl-3-[[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulphonyl]amino]propylammonium hydroxide	252-046-8	34455-29-3	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020	01/02/2021 01/02/2021	Details
Tris(nitrato-O)nitrosylruthenium	252-068-8	34513-98-9	Genetic toxicity in vivo	01/07/2021	16/08/2021	Details
tert-butyl α,α-dimethylbenzyl peroxide	222-389-8	3457-61-2	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates	16/03/2015	30/04/2015	Details
tert-butyl α,α-dimethylbenzyl peroxide	222-389-8	3457-61-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
1-imino-1H-isoindol-3-amine	222-426-8	3468-11-9	Genetic toxicity in vivo	27/01/2020	12/03/2020	Details
1-imino-1H-isoindol-3-amine	222-426-8	3468-11-9	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid	252-156-6	34690-00-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposal is based on concern identified by the registrant.	20/05/2015 20/05/2015	06/07/2015 06/07/2015	Details
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid	252-156-6	34690-00-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP	31/01/2018 31/01/2018	19/03/2018 19/03/2018	Details
1-butylpyrrolidin-2-one	222-437-8	3470-98-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/01/2022	11/03/2022	Details
triethoxy(3-thiocyanatopropyl)silane	252-161-3	34708-08-2	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/10/2014 16/10/2014 16/10/2014	01/12/2014 01/12/2014 01/12/2014	Details
Sodium 2-[(2-aminoethyl)amino]ethanesulphonate	252-173-9	34730-59-1	Reproductive toxicity (pre-natal developmental toxicity)	29/04/2014	13/06/2014	Details
Propanamide, 2-hydroxy-N,N-dimethyl-	609-066-0	35123-06-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	21/10/2021	07/12/2021	Details
Propanamide, 2-hydroxy-N,N-dimethyl-	609-066-0	35123-06-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	18/03/2021	03/05/2021	Details
Trinonyl benzene-1,2,4-tricarboxylate	252-552-9	35415-27-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	11/11/2016 11/11/2016	03/01/2017 03/01/2017	Details
Triethoxy(2,4,4-trimethylpentyl)silane	252-558-1	35435-21-3	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	29/04/2011 29/04/2011	14/06/2011 14/06/2011	Details
Triethoxy(2,4,4-trimethylpentyl)silane	252-558-1	35435-21-3	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1)	28/02/2018 28/02/2018	16/04/2018 16/04/2018	Details
N,N''-propane-1,3-diylbis[N'-octadecylurea	252-667-4	35674-65-8	Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity)	29/03/2016	13/05/2016	Details
Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), reaction products with 1-tetradecanamine and urea	436-230-7	359406-89-6	Sub-chronic toxicity (90-day): oral	06/03/2012	20/04/2012	Details
N-butyl-2,2,6,6-tetramethylpiperidin-4-amine	252-899-6	36177-92-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): ora	07/10/2016 07/10/2016	21/11/2016 21/11/2016	Details
N-butylbenzenesulphonamide	222-823-6	3622-84-2	Reproductive toxicity (pre-natal developmental toxicity)	14/02/2011	31/03/2011	Details
N-butylbenzenesulphonamide	222-823-6	3622-84-2	Reproductive toxicity (pre-natal developmental toxicity)	29/02/2016	14/04/2016	Details
1,3-bis(isocyanatomethyl)benzene	222-852-4	3634-83-1	6.1.2 Long-term toxicity to fish	08/03/2024	22/04/2024	Details
4,4`-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with methacrylic acid	500-089-0	36425-15-7	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011	Details
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid	500-090-6	36425-16-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with a structurally related substance (small vinyl ester)	31/05/2016 31/05/2016	15/07/2016 15/07/2016	Details
Dioctyltin dilaurate	222-883-3	3648-18-8	Reproductive toxicity (pre-natal developmental toxicity)	23/03/2020	07/05/2020	Details
Diundecyl phthalate	222-884-9	3648-20-2	Reproductive toxicity (pre-natal developmental toxicity)	25/11/2021	10/01/2022	Details
2,2-dimethylpropan-1-ol, tribromo derivative	253-057-0	36483-57-5	Reproductive toxicity (pre-natal developmental toxicity)	17/04/2015	04/06/2015	Details
2-Oxepanone, polymer with 1,6-hexanediol	609-271-5	36609-29-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol	16/10/2014 16/10/2014	01/12/2014 01/12/2014	Details

Showing 1,151 - 1,200 of 2,011 results.

Export in: