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Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 

Further information

 

For more information on these substances, please go to
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There are currently no ongoing consultations.
Page 13 of 41
50 Items per Page
Showing 601 - 650 of 2,011 results.
Name
EC Number
CAS Number
Hazard endpoint for which vertebrate testing was proposed
Date of publication to call for available information
Deadline for submitting information
Alternatives to vertebrate testing
 
4-fluoro-1,3-dioxolan-2-one 483-360-5 114435-02-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 24/07/2019 09/09/2019 Details
N-[3-(dimethylamino)propyl] C 12-C18 alkylamide 932-121-8 1147459-12-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
03/11/2014
03/11/2014
 Details
Propene 204-062-1 115-07-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with ethylene (EC no. 200-815-3)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
 Details
2-methylpropene 204-066-3 115-11-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
06/06/2023
06/06/2023
06/06/2023
21/07/2023
21/07/2023
21/07/2023
 Details
2-methylpropene 204-066-3 115-11-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance belongs to a category and testing is proposed with the Substance (EC 204-066-3) and Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1)
Reproductive toxicity (pre-natal developmental toxicity) || Note: substance belongs to a category and testing is proposed with the Substance (EC 204-066-3) and Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1)
Sub-chronic toxicity (90 day): inhalation || Note: substance belongs to a category and testing is proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1)
16/12/2020
16/12/2020
16/12/2020
01/02/2021
01/02/2021
01/02/2021
 Details
2-methylbut-3-yn-2-ol 204-070-5 115-19-5 Sub-chronic toxicity (90-day): oral 20/04/2015 08/06/2015 Details
2-amino-2-ethylpropanediol 204-101-2 115-70-8
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-amino-1,3-propanediol
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-amino-1,3-propanediol
18/09/2014
18/09/2014
03/11/2014
03/11/2014
 Details
2,2-Bis(hydroxymethyl)-1,3-propanediol (pentaerythritol) 204-104-9 115-77-5 Reproductive toxicity (pre-natal developmental toxicity) 15/03/2011 29/04/2011 Details
Pentaerythritol 204-104-9 115-77-5 Long-term toxicity to fish 03/05/2023 19/06/2023 Details
pentaerythritol 204-104-9 115-77-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
20/12/2017
20/12/2017
05/02/2018
05/02/2018
 Details
2-butyl-2-ethylpropanediol 204-111-7 115-84-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/02/2011
14/02/2011
31/03/2011
31/03/2011
 Details
Linalyl acetate 204-116-4 115-95-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 17/06/2020 03/08/2020 Details
4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco 500-303-2 115340-85-7 Genetic toxicity in vivo 21/01/2021 08/03/2021 Details
Hydroxyacetone 204-124-8 116-09-6 Genetic toxicity in vivo 23/11/2020 07/01/2021 Details
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (pre-natal developmental toxicity) 31/07/2015 14/09/2015 Details
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018 Details
Alcohols, C18-22, distn. residues 641-136-6 1160164-88-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018 Details
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] 601-409-2 116020-44-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
 Details
Ureidopropyltrialkoxysilane 449-160-7 116912-64-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
 Details
2,4,6-trinitrotoluene 204-289-6 118-96-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
04/04/2014
04/04/2014
04/04/2014
19/05/2014
19/05/2014
19/05/2014
 Details
Trimethylamine, N-oxide 214-675-6 1184-78-7 Genetic toxicity in vivo||Note: testing proposed with Reference substance 001 [CAS No. 62637-93-8] 06/06/2023 21/07/2023 Details
Trimethoxy(methyl)silane 214-685-0 1185-55-3
Reproductive toxicity (extended one-generation reproductive toxicity study
Reproductive toxicity (pre-natal developmental toxicity)
12/04/2017
12/04/2017
29/05/2017
29/05/2017
 Details
Trifluoro(trifluoromethoxy)ethylene 214-703-7 1187-93-5 Sub-chronic toxicity (90 day): inhalation 29/04/2014 13/06/2014 Details
Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide 810-703-1 1187441-10-6 Genetic toxicity in vivo 23/03/2020 07/05/2020 Details
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol 204-327-1 119-47-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018 Details
6,6`-di-tert-butyl-2,2`-methylenedi-p-cresol 204-327-1 119-47-1 Reproductive toxicity (two-generation reproductive toxicity) 16/05/2011 30/06/2011 Details
1,2,3,4-tetrahydronaphthalene 204-340-2 119-64-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018 Details
1,2,3,4-tetrahydronaphthalene 204-340-2 119-64-2 Reproductive toxicity (two-generation reproductive toxicity) 16/06/2011 01/08/2011 Details
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts 601-601-6 119345-04-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit
27/05/2019
27/05/2019
11/07/2019
11/07/2019
 Details
1,3-diphenylpropane-1,3-dione 204-398-9 120-46-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
18/09/2014
03/11/2014
03/11/2014
03/11/2014
 Details
1,2-dihydroxybenzene,pyrocatechol 204-427-5 120-80-9
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
15/04/2011
15/04/2011
30/05/2011
30/05/2011
 Details
2-imidazolidone 204-436-4 120-93-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
Cobalt hydroxide oxide 234-614-7 12016-80-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
 Details
Cobalt hydroxide oxide 234-614-7 12016-80-7
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Cobalt sulphide (EC 215-273-3) || Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant
21/09/2020
21/09/2020
21/09/2020
05/11/2020
05/11/2020
05/11/2020
 Details
Vanadium dioxide 234-841-1 12036-21-4
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: : testing proposed with Sodium metavanadate (EC no. 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)
16/06/2022
16/06/2022
01/08/2022
01/08/2022
 Details
praseodymium(III,IV) oxide 234-857-9 12037-29-5 Genetic toxicity in vivo 18/09/2014 03/11/2014 Details
4-chloroformylphthalic anhydride 214-874-8 1204-28-0 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. 		27/01/2020 12/03/2020 Details
barium titanium trioxide 234-975-0 12047-27-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
17/04/2015
17/04/2015
04/06/2015
04/06/2015
 Details
α-methyl-1,3-benzodioxole-5-propionaldehyde 214-881-6 1205-17-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 31/01/2023 17/03/2023 Details
potassium titanium oxide (K2Ti6O13) 432-240-0 12056-51-8 Long-term toxicity to fish 17/05/2017 03/07/2017 Details
4-nitrotoluene-2-sulphonic acid 204-445-3 121-03-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
30/05/2011
30/05/2011
 Details
Trimethyl borate 204-468-9 121-43-7
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with boric acid.
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with boric acid.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with boric acid.
15/04/2014
15/04/2014
15/04/2014
30/05/2014
30/05/2014
30/05/2014
 Details
N,N,N`,N`,N``-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride 629-716-7 1211950-04-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
29/08/2011
29/08/2011
 Details
Copper hydroxide nitrate 439-590-3 12158-75-7 Reproductive toxicity (pre-natal developmental toxicity) 03/11/2011 19/12/2011 Details
2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol 620-540-6 1218787-32-6 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,2'-(Octadec-9-enylimino) bisethanol, CAS No 25307-17-9 14/03/2016 28/04/2016 Details
Cobalt lithium dioxide 235-362-0 12190-79-3
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
 Details
reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated 846-447-2 1219458-07-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
24/02/2020
24/02/2020
09/04/2020
09/04/2020
 Details
N-(3-aminopropyl)-N`-[3-(C16-18 (evennumbered), C18 unsaturated alkyl amino)propyl]propane-1,3-diamine 628-862-9 1219458-11-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
29/08/2011
29/08/2011
 Details
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine 628-863-4 1219458-14-6 Reproductive toxicity (pre-natal developmental toxicity) 24/01/2019 11/03/2019 Details
4-phenylbutenone 204-555-1 122-57-6 Genetic toxicity in vivo 23/03/2020 07/05/2020 Details
Page 13 of 41
50 Items per Page
Showing 601 - 650 of 2,011 results.