Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
Strontium chromate | 232-142-6 | 7789-06-2 | Long-term toxicity to fish | 31/05/2011 | 15/07/2011 | Details | |
Styrene | 202-851-5 | 100-42-5 | Long-term toxicity to fish | 30/06/2023 | 14/08/2023 | Details | |
Styrene | 202-851-5 | 100-42-5 | Long-term toxicity to fish | 04/09/2023 | 19/10/2023 | Details | |
SUMILIZER GP | 442-450-4 | - | Long-term toxicity to fish | 25/11/2021 | 10/01/2022 | Details | |
tert-butyl perbenzoate | 210-382-2 | 614-45-9 | Long-term toxicity to fish | 23/03/2020 | 07/05/2020 | Details | |
tert-dodecanethiol | 246-619-1 | 25103-58-6 | Long-term toxicity to fish | 16/06/2022 | 01/08/2022 | Details | |
Tetramethylammonium hydroxide | 200-882-9 | 75-59-2 | Long-term toxicity to fish | 30/06/2023 | 14/08/2023 | Details | |
Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate | 266-442-3 | 66669-53-2 | Long-term toxicity to fish | 22/09/2022 | 07/11/2022 | Details | |
trimethoxy(2,4,4-trimethylpentyl)silane | 251-995-5 | 34396-03-7 | Long-term toxicity to fish | 26/10/2022 | 12/12/2022 | Details | |
Trimethylolpropane and its reaction products with methyloxirane | 957-630-2 | - | Long-term toxicity to fish | 15/01/2024 | 29/02/2024 | Details | |
Triphenylphosphine | 210-036-0 | 603-35-0 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
undec-10-enoic acid | 203-965-8 | 112-38-9 | Long-term toxicity to fish | 16/10/2014 | 01/12/2014 | Details | |
Fatty acids, tall-oil, di- and triesters with trimethylolpropane | 941-376-4 | - |
Long-term toxicity to aquatic invertebrates Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. Testing proposed with EC No 931-531-4. |
31/05/2016 31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 15/07/2016 |
Details | |
p-phenylenediammine | 203-404-7 | 106-50-3 | Long-term toxicity testing to fish | 26/01/2011 | 14/03/2011 | Details | |
N-methylaniline | 202-870-9 | 100-61-8 |
Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): dermal |
01/07/2011 01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 15/08/2011 |
Details | |
2-aminoethanol, monoester with boric acid | 233-829-3 | 10377-81-8 |
Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 |
Details | |
Orthoboric acid, compound with 2-aminoethanol | 247-421-8 | 26038-87-9 |
Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
Trimethylamine, N-oxide | 214-675-6 | 1184-78-7 | Genetic toxicity in vivo||Note: testing proposed with Reference substance 001 [CAS No. 62637-93-8] | 06/06/2023 | 21/07/2023 | Details | |
Slimes and Sludges, blast furnace and steelmaking | 266-006-2 | 65996-73-8 | Genetic toxicity in vivo||Note: testing proposed with Iron (EC no. 231-096-4), Calcium oxide (EC no. 215-138-9), Magnesium oxide (EC no. 215-171-9), Zinc (EC no. 231-175-3) and Manganese (EC no. 231-105-1) | 30/06/2023 | 14/08/2023 | Details | |
Reaction products of boric acid and calcium dihydroxide and lithium hydroxide | 701-453-3 | - | Genetic toxicity in vivo||Note: testing proposed with diboron calcium tetraoxide (EC no. 237-224-5) | 22/09/2022 | 07/11/2022 | Details | |
Residues (petroleum), thermal cracked vacuum | 295-518-9 | 92062-05-0 |
Genetic toxicity in vivo||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Asphalt (EC no. 232-490-9) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Asphalt (EC no. 232-490-9) |
04/12/2023 04/12/2023 04/12/2023 04/12/2023 |
18/01/2024 18/01/2024 18/01/2024 18/01/2024 |
Details | |
Residues (petroleum), vacuum | 265-057-8 | 64741-56-6 |
Genetic toxicity in vivo||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Asphalt (EC no. 232-490-9) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Asphalt (EC no. 232-490-9) |
04/12/2023 04/12/2023 04/12/2023 04/12/2023 |
18/01/2024 18/01/2024 18/01/2024 18/01/2024 |
Details | |
Reaction mass of trientine and trientine, mono- and di-propoxylated | 942-835-1 | - | Genetic toxicity in vivo||Note: testing proposed with [Amines, polyethylenepoly-, triethylenetetramine fraction] (EC no. 292-588-2) | 03/10/2023 | 17/11/2023 | Details | |
tetraammine platinum (II) hydrogen carbonate | 426-730-3 | 123439-82-7 | Genetic toxicity in vivo|| Note: Testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. | 25/10/2017 | 11/12/2017 | Details | |
triethoxy(3-isocyanatopropyl)silane | 246-467-6 | 24801-88-5 | Genetic toxicity in vivo Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9) | 03/02/2016 | 21/03/2016 | Details | |
N,N'-diphenyl-p-phenylenediamine | 200-806-4 | 74-31-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate | 220-482-8 | 2781-11-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine | 264-438-6 | 63738-22-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Dibutyl itaconate | 218-451-9 | 2155-60-4 |
Genetic toxicity in vivo Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
Reaction mass of 2-(1,1-dimethylpropyl)anthraquinone and 2-(1,2-dimethylpropyl)anthraquinone | 915-623-1 | - |
Genetic toxicity in vivo Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Flue dust, portland cement | 270-659-9 | 68475-76-3 |
Genetic toxicity in vivo Sub-chronic toxicity (90 day): inhalation |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/01/2012 16/01/2012 16/01/2012 |
01/03/2012 01/03/2012 01/03/2012 |
Details | |
1,3-diphenylpropane-1,3-dione | 204-398-9 | 120-46-7 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 03/11/2014 |
Details | |
1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate | 925-259-5 | 140921-24-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 30/06/2014 |
Details | |
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate | 255-180-5 | 41026-17-9 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/12/2016 16/12/2016 16/12/2016 |
30/01/2017 30/01/2017 30/01/2017 |
Details | |
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 260-829-0 | 57583-35-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 248-227-6 | 27107-89-7 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2011 16/05/2011 16/05/2011 |
30/06/2011 30/06/2011 30/06/2011 |
Details | |
3-(triethoxysilyl)propanethiol | 238-883-1 | 14814-09-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropionate | 214-222-2 | 1115-20-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 15/07/2011 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers | 500-180-5 | 67989-52-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
7-hydroxycitronellal | 203-518-7 | 107-75-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2023 31/01/2023 31/01/2023 |
17/03/2023 17/03/2023 17/03/2023 |
Details | |
Amino functional alkoxysilanes | 701-410-9 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
Bisisobutyryl peroxide | 222-340-0 | 3437-84-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 19/05/2014 |
Details | |
Coconut oil, reaction products with polyethylene glycol and trimethylolpropane | 640-964-5 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
di-p-tolyl(2,4,6-trimethylbenzoyl)phosphine oxide | 884-585-5 | 270586-78-2 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/06/2023 30/06/2023 30/06/2023 |
14/08/2023 14/08/2023 14/08/2023 |
Details | |
Dimethyl sebacate | 203-431-4 | 106-79-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2014 31/01/2014 31/01/2014 |
17/03/2014 17/03/2014 17/03/2014 |
Details | |
Formaldehyde, oligomeric reaction products with phenol and m-phenylenebis(methylamine) | 500-137-0 | 57214-10-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/11/2015 30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 14/01/2016 |
Details | |
Methanal, reaction products with 1,3-bis(aminomethyl)benzene and hydroxybenzen | 701-207-5 | 1950616-36-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/05/2018 21/05/2018 21/05/2018 |
05/07/2018 05/07/2018 05/07/2018 |
Details | |
Methyl [3-(trimethoxysilyl)propyl]carbamate | 245-659-7 | 23432-62-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/03/2017 10/03/2017 10/03/2017 |
25/04/2017 25/04/2017 25/04/2017 |
Details | |
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide | 419-710-0 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
12/12/2014 12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 26/01/2015 |
Details | |
N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine | 278-817-9 | 78014-16-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/08/2021 26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 11/10/2021 |
Details | |
N-isopropylhydroxylamine | 225-791-1 | 5080-22-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 |
Details | |
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate | 252-029-5 | 34443-12-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/03/2014 21/03/2014 21/03/2014 |
05/05/2014 05/05/2014 05/05/2014 |
Details | |
tert-butyl 2-ethylperoxyhexanoate | 221-110-7 | 3006-82-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
tert-butyl 3,5,5-trimethylperoxyhexanoate | 236-050-7 | 13122-18-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
triethoxy(3-thiocyanatopropyl)silane | 252-161-3 | 34708-08-2 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
Vinylene carbonate | 212-825-5 | 872-36-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/05/2021 20/05/2021 20/05/2021 |
05/07/2021 05/07/2021 05/07/2021 |
Details | |
Diisopentyl ether | 208-857-4 | 544-01-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation |
18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 |
Details | |
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate | 255-180-5 | 41026-17-9 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 30/06/2014 30/06/2014 |
Details | |
4,4'-Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-070-7 | 30583-72-3 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 17/07/2014 |
Details | |
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 275-662-9 | 71604-74-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether | 221-453-2 | 3101-60-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2014 17/06/2014 17/06/2014 17/06/2014 |
01/08/2014 01/08/2014 01/08/2014 01/08/2014 |
Details | |
2,2`-iminodi(ethylamine),N-(2-aminoethyl)ethane-1,2-diamine | 203-865-4 | 111-40-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
05/04/2011 05/04/2011 05/04/2011 |
20/05/2011 20/05/2011 20/05/2011 |
Details | |
Slimes and Sludges, blast furnace and steelmaking | 266-006-2 | 65996-73-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
2-ethylanthraquinone | 201-535-4 | 84-51-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
4,6-dichloro-N-(1,1,3,3-tetramethylbutyl)-1,3,5-triazin-2-amine | 276-309-1 | 72058-41-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
arbonohydrazide | 207-837-2 | 497-18-7 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Diamminediisocyanatozinc | 401-610-3 | 122012-52-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
dimethoxydimethylsilane | 214-189-4 | 1112-39-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
28/11/2022 28/11/2022 |
12/01/2023 12/01/2023 |
Details | |
N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide | 218-915-0 | 2280-49-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Polyphosphoric acids, esters with triethanolamine, sodium salts | 268-625-3 | 68131-72-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
Product of Semi-Dry Absorption method of Flue Gas Desulphurization (SDA Product) | 931-259-6 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 |
Details | |
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- | 911-490-9 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/11/2014 18/11/2014 |
02/01/2015 02/01/2015 |
Details | |
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 260-829-0 | 57583-35-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity Sub-chronic toxicity (90-day): oral |
01/09/2016 01/09/2016 01/09/2016 |
17/10/2016 17/10/2016 17/10/2016 |
Details | |
Asphalt | 232-490-9 | 8052-42-4 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/12/2023 04/12/2023 04/12/2023 04/12/2023 |
18/01/2024 18/01/2024 18/01/2024 18/01/2024 |
Details | |
Gas oils (petroleum), light vacuum | 265-059-9 | 64741-58-8 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): dermal Sub-chronic toxicity (90-day): oral |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | 32492-61-8 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Fuel oil, no. 4 | 270-673-5 | 68476-31-3 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum, (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): dermal |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Distillates (petroleum), light hydrocracked | 265-078-2 | 64741-77-1 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): dermal |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fuels, diesel | 269-822-7 | 68334-30-5 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) |
07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 |
Details | |
3-(trimethoxysilyl)propyl isocyanate | 239-415-9 | 15396-00-6 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: it is proposed to use the information from an ongoing study with 3-(trimethoxysilyl)propylamine (EC 237-511-5) |
30/09/2021 30/09/2021 |
15/11/2021 15/11/2021 |
Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) |
01/09/2017 01/09/2017 |
16/10/2017 16/10/2017 |
Details | |
Bis(2-chloroethoxy)methane 1,15-dichloro-3,5,8,11,13-penta-oxa pentadecane 1-(2-chloroethoxy)-2-(2-chloroethoxymethoxy)ethane | 940-783-4 | - |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (two-generation reproductive toxicity) // Note: test to be performed with analogues substance 1-chloro-2-[(2-chloroethoxy)methoxy]ethane (EC 203-920-2 ) |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
3-hydroxy-2-(hydroxymethyl)-2-methylpropanal | 242-393-3 | 18516-18-2 |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/06/2011 16/06/2011 16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 01/08/2011 01/08/2011 |
Details | |
[4-[p,p'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium m-[[p-anilinophenyl]azo]benzenesulphonate | 265-449-9 | 65113-55-5 |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 04/04/2014 |
Details | |
Reaction mass of N-[2-(2-oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid | 934-058-1 | - |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 30/06/2014 30/06/2014 |
Details | |
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid | - | - |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2011 16/08/2011 16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 30/09/2011 30/09/2011 |
Details | |
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane | 219-863-1 | 2554-06-5 |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation |
03/03/2014 03/03/2014 03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 17/04/2014 17/04/2014 |
Details | |
4,4'-methylenebis[2,6-diethylaniline] | 237-185-4 | 13680-35-8 |
Genetic toxicity in vivo Long-term toxicity to fish |
26/03/2018 26/03/2018 |
11/05/2018 11/05/2018 |
Details | |
Hexanal | 200-624-5 | 66-25-1 | Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” | 27/05/2019 | 11/07/2019 | Details | |
Propionaldehyde, reaction product with formaldehyde | 701-281-9 | - | Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. | 10/12/2018 | 24/01/2019 | Details | |
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 225-716-2 | 5026-74-4 |
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 225-716-2 | 5026-74-4 |
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |
Tetraammineplatinum dinitrate | 243-929-9 | 20634-12-2 | Genetic toxicity in vivo || Note: testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. | 28/02/2018 | 16/04/2018 | Details | |
Dihydrogen hexahydroxyplatinate | 257-471-2 | 51850-20-5 | Genetic toxicity in vivo || Note: Testing proposed with dihydrogen hexahydroxyplatinate(IV), compound with 2-aminoethanol (1:2). Testing proposal is based on concern identified by the registrant. | 28/02/2018 | 16/04/2018 | Details | |
Hexachloroplatinic acid | 241-010-7 | 16941-12-1 | Genetic toxicity in vivo || Note: testing proposed with Diammonium hexachloroplatinate (EC 241-010-7). Testing proposal is based on concern identified by the registrant. | 26/03/2018 | 11/05/2018 | Details | |
4-tert-butylpyrocatechol | 202-653-9 | 98-29-3 |
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
(3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde | 801-656-8 | 1416808-92-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/04/2015 | 04/06/2015 | Details | |
2,2-dimethyl-3-oxopropyl acetate | 811-188-6 | 16184-79-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 01/09/2017 | 16/10/2017 | Details | |
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane | 220-780-8 | 2897-60-1 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 16/12/2016 | 30/01/2017 | Details | |
Copper (2+), bis [N-{amino (imino-KN) methyl} urea-KO]-, nitrate (1:2) | 800-038-5 | 1071838-81-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/01/2015 | 09/03/2015 | Details | |
Dialkyl-methyl-dihydro-heteropolycyle | 815-131-6 | 913171-06-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/03/2020 | 07/05/2020 | Details | |
Diammonium hexachloroplatinate | 240-973-0 | 16919-58-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/04/2018 | 07/06/2018 | Details | |
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | 268-717-3 | 68133-90-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 04/10/2018 | 19/11/2018 | Details | |
Dipotassium hexachloroplatinate | 240-979-3 | 16921-30-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 26/03/2018 | 11/05/2018 | Details | |
Everzol Red CDN Crude | 483-940-8 | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 31/01/2018 | 19/03/2018 | Details | |
Tetraammineplatinum dichloride | 237-706-5 | 13933-32-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 28/02/2018 | 16/04/2018 | Details | |
3,5-diamino-4-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]benzoic acid sodium salt | 480-890-9 | 906532-68-1 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 18/11/2014 | 02/01/2015 | Details | |
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione | 276-763-0 | 72676-55-2 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 20/10/2016 | 05/12/2016 | Details | |
Dimethyl (p-methoxybenzylidene)malonate | 231-185-8 | 7443-25-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide | 806-543-7 | 215917-77-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 30/11/2015 | 14/01/2016 | Details | |
Aluminium oxide | 215-691-6 | 1344-28-1 | Genetic toxicity in vivo || Note: Testing proposal for two in vivo studies is based on concern identified by the registrant. Testing proposed with Aluminium oxide nanoscale material. | 28/02/2018 | 16/04/2018 | Details | |
Reaction mass of N,N,N',N'-tetrabutylmethylenediamine and dibutylamine | 948-040-6 | - | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
Dipotassium tetrachloroplatinate | 233-050-9 | 10025-99-7 | Genetic toxicity in vivo || Note: "Testing proposal is based on concern identified by the registrant." | 18/06/2018 | 02/08/2018 | Details | |
Dicyclohexylamine | 202-980-7 | 101-83-7 |
Genetic toxicity in vivo (mammalian bone marrow chromosome aberration test) Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/03/2011 15/03/2011 15/03/2011 15/03/2011 |
29/04/2011 29/04/2011 29/04/2011 29/04/2011 |
Details | |
Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 13/05/2019 13/05/2019 |
Details | |
Tetraammineplatinum (II) diacetate | 457-310-8 | - | Genetic toxicity in vivo (COMET, OECD TG 489) || Note: Testing proposal is based on concern identified by the registrant. Testing proposed with Tetraammineplatinum dichloride (CAS 13933-32-9). | 22/06/2017 | 07/08/2017 | Details | |
Neodecanoic acid, cobalt salt | 248-373-0 | 27253-31-2 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant | 21/01/2021 | 08/03/2021 | Details | |
Cobalt, borate neodecanoate complexes | 270-601-2 | 68457-13-6 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) | 21/01/2021 | 08/03/2021 | Details | |
Resin acids and Rosin acids, cobalt salts | 273-321-9 | 68956-82-1 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) | 21/01/2021 | 08/03/2021 | Details | |
Stearic acid, cobalt salt | 237-016-4 | 13586-84-0 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) | 21/01/2021 | 08/03/2021 | Details | |
Reaction mass of bisisopropyl peroxydicarbonate and bis-sec-butyl peroxydicarbonate and isopropyl-sec-butylperoxydicarbonate | 931-536-1 | - | Genetic toxicity in vivo || Note: testing proposed with bisisopropyl peroxydicarbonate EC 203-317-4, CAS 105-64-6 (is a constituent of the multi-constituent registered substance) || Note: Testing proposal is based on concern identified by the registrant | 24/08/2020 | 08/10/2020 | Details | |
4-fluoro-1,3-dioxolan-2-one | 483-360-5 | 114435-02-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl ethyl carbonate | 254-959-7 | 40530-60-7 | Genetic toxicity in vivo || Note: testing proposed with Disperse Red 302:1 (EC 248-882-8) | 23/11/2020 | 07/01/2021 | Details | |
Cobalt lithium dioxide | 235-362-0 | 12190-79-3 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
Cobalt sulphide | 215-273-3 | 1317-42-6 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
Cobalt hydroxide oxide | 234-614-7 | 12016-80-7 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Cobalt sulphide (EC 215-273-3)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
Tricobalt tetraoxide | 215-157-2 | 1308-06-1 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Cobalt sulphide (EC 215-273-3)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
Gas oils (petroleum), hydrodesulfurized light vacuum | 265-190-1 | 64742-87-6 |
Genetic toxicity in vivo
|| Note: testing proposed with category members Gas oils (petroleum), light vacuum (EC 265-059-9), Fuels, diesel (EC 269-822-7), Fuel oil, no. 4 (EC 270-673-5), Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) 1st (Rat) and 2nd species (Rabbit) (Dermal route)
|| Note: testing proposed with category members Gas oils (petroleum), light vacuum (EC 265-059-9), Fuels, diesel (EC 269-822-7), Fuel oil, no. 4 (EC 270-673-5), Distillates (petroleum), light hydrocracked (EC 265-078-2) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with category members
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Condensates (petroleum), vacuum tower | 265-049-4 | 64741-49-7 |
Genetic toxicity in vivo
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuels, diesel (EC 269-822-7)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fuel oil, no. 2 | 270-671-4 | 68476-30-2 |
Genetic toxicity in vivo
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuels, diesel (EC 269-822-7)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fuels, diesel, no. 2 | 270-676-1 | 68476-34-6 |
Genetic toxicity in vivo
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuels, diesel (EC 269-822-7)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
(octahydro-4,7-methano-1H-indenyl)methyl acrylate | 300-723-4 | 93962-84-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
3-[(3-{[(3-acetoxy-2,2-dimethylpropylidene)amino]methyl}-3,5,5-trimethylcyclohexyl)imino]-2,2-dimethylpropyl acetate | 805-722-7 | 1064082-81-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
Fluoren-9-one | 207-630-7 | 486-25-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
Hydrogen [4-[[4-(diethylamino)phenyl][4-[ethyl[(3-sulphonatobenzyl)amino]-o-tolyl]methylene]-3-methylcyclohexa-2,5-dien-1-ylidene](ethyl)(3-sulphonatobenzyl)ammonium, sodium salt | 229-390-2 | 6505-30-2 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide | 246-058-2 | 24170-60-3 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
Trisodium 4-amino-5-hydroxy-3-[[4-[[2-oxo-1-[(phenylamino)carbonyl]propyl]azo]phenyl]azo]-6-[(4-sulphonato-1-naphthyl)azo]naphthalene-2,7-disulphonate | 279-093-7 | 79135-92-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 21/01/2021 | 08/03/2021 | Details | |
4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane | 240-212-2 | 16068-37-4 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 03/08/2020 03/08/2020 |
Details | |
2-[[(butylamino)carbonyl]oxy]ethyl acrylate | 264-036-0 | 63225-53-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | 2530-83-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
Alkanoic acid and polyoxomolybdate borate alkanoate clusters | 944-813-7 | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 24/08/2020 | 08/10/2020 | Details | |
Bisisopropyl peroxydicarbonate | 203-317-4 | 105-64-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 24/08/2020 | 08/10/2020 | Details | |
Potassium dicyanoaurate | 237-748-4 | 13967-50-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
2-hydroxy-3-propyl-2H-furan-5-one | 821-451-7 | 78920-10-2 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. || |
25/11/2019 | 09/01/2020 | Details | |
Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. |
25/11/2019 | 09/01/2020 | Details | |
Dihydrogen hexahydroxyplatinate | 257-471-2 | 51850-20-5 | Genetic toxicity in vivo || Note: testing proposed with dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) (EC 268-717-3) | 21/12/2021 | 04/02/2022 | Details | |
Iron, complexes with diazotized 5-amino-2-(phenylamino)benzenesulfonic acid monosodium salt coupled with 4-[(2-hydroxy-3,5-dinitrophenyl)azo]-1,3-benzenediol, diazotized 4-nitrobenzenamine and diazotized 3-aminobenzenesulfonic acid monosodium salt | 276-464-5 | 72207-77-3 | Genetic toxicity in vivo || Note: testing proposed with Acid Brown 360 (EC 946-788-8) | 20/05/2021 | 05/07/2021 | Details | |
isliFe | - | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl triacrylate | 254-843-6 | 40220-08-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate | 276-957-5 | 72869-86-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
[1R-(1α,2β,5α)]-1-(isopropyl)-2-methoxy-4-methylcyclohexane | 216-365-6 | 1565-76-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
Disodium 5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxy-6-(methylamino)naphthalene-2-sulphonate | 274-436-7 | 70210-39-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-[(4-methyl-3-sulphonatophenyl)sulphonyl]phenyl]azo]naphthalene-2-sulphonate | 286-122-7 | 85187-33-3 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 18/02/2021 | 05/04/2021 | Details | |
Essential oil of Spearmint obtained from the aerial part of Mentha spicata and/or Mentha cardiaca (Lamiaceae) obtained by distillation | 946-253-9 | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with diethylamine | 500-425-6 | 159034-91-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 16/12/2020 | 01/02/2021 | Details | |
Reaction mass of 6-Chloro-2-{4[ethyl(2-hydroxyethyl)amino]phenyl}-1-methylbenzo[cd]indolium hydroxide and 6-chloro-2-[4-[ethyl(2-hydroxyethyl)amino]phenyl]-1-methylbenz[cd]indolium acetate | 946-378-9 | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 16/12/2020 | 01/02/2021 | Details | |
Reaction mass of Disodium dihydroxy[3-(hydroxy-kO)-4-{[5-(hydroxy-kO)-3-methyl-1-phenyl-1Hpyrazol-4-yl]diazenyl-kN1}naphthalene-1-sulfonato(3-)]chromate(2-) and sodium [4-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-3-hydroxynaphthalene-1-sulphonato(3-)]hydroxychromate(1-) | 944-272-7 | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
(2-ethyl-2-methyl-1,3-dioxolan-4-yl)methyl prop-2-enoate | 807-159-2 | 69701-99-1 | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
(chloromethyl)triethoxysilane | 239-311-3 | 15267-95-5 | Genetic toxicity in vivo | 16/10/2014 | 01/12/2014 | Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates | 282-617-7 | 84281-74-3 | Genetic toxicity in vivo | 25/11/2021 | 10/01/2022 | Details | |
1,3-diphenyl-2-thiourea | 203-004-2 | 102-08-9 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
1,7-Naphthalenedisulfonic acid, 2-[[4-chloro-6-(cyanoamino)-1,3,5-triazin-2-yl]amino]-5-hydroxy-6-[2-[2-methoxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]-, lithium sodium salt (1:?:?) | 440-050-4 | 243857-97-8 | Genetic toxicity in vivo | 03/05/2023 | 19/06/2023 | Details | |
1,8-naphthylenediamine | 207-529-8 | 479-27-6 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
1-(4-(ACETYLOXY)-3-((ACETYLOXY)METHYL)PHENYL)ETHANONE | 921-042-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
1-bromopropane (n-propyl bromide) | 203-445-0 | 106-94-5 | Genetic toxicity in vivo | 15/04/2011 | 30/05/2011 | Details | |
1-hydroxy-4-[[4-[(methylsulphonyl)oxy]phenyl]amino]anthraquinone | 216-475-4 | 1594-08-7 | Genetic toxicity in vivo | 01/07/2021 | 16/08/2021 | Details | |
1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
1-methyl-4-(methylsulfonyl)-2-nitrobenzene | 430-550-0 | 1671-49-4 | Genetic toxicity in vivo | 16/05/2011 | 30/06/2011 | Details | |
14H-benz[4,5]isoquino[2,1-a]perimidin-14-one | 229-904-5 | 6829-22-7 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
2'-phenylacetohydrazide | 204-055-3 | 114-83-0 | Genetic toxicity in vivo | 03/10/2023 | 17/11/2023 | Details | |
2,2'-[(1-methylethylidene)bis(cyclohexane-4,1-diyloxymethylene)]bisoxirane | 236-502-3 | 13410-58-7 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
2,2'-azobis[4-methoxy-2,4-dimethylvaleronitrile] | 239-593-8 | 15545-97-8 | Genetic toxicity in vivo | 17/06/2020 | 03/08/2020 | Details | |
2,3-epoxypropyl isopropyl ether | 223-672-9 | 4016-14-2 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
2,4-dihydroxybenzophenone | 205-029-4 | 131-56-6 | Genetic toxicity in vivo | 03/10/2023 | 17/11/2023 | Details | |
2,5-bis(1,1,3,3-tetramethylbutyl)hydroquinone | 212-990-3 | 903-19-5 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
2,7-naphthalenedisulfonic acid, 4-amino-5-hydroxy-, diazotized, coupled with diazotized 2-amino-4,6-dinitrophenol, diazotized 4-nitrobenzenamine and resorcinol, sodium salts | 232-380-0 | 8011-86-7 | Genetic toxicity in vivo | 21/10/2021 | 07/12/2021 | Details | |
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate | 224-116-8 | 4203-89-8 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
2-(2-naphthyloxy)ethanol | 202-228-8 | 93-20-9 | Genetic toxicity in vivo | 16/05/2014 | 30/06/2014 | Details | |
2-(2-thienyl)ethyl toluene-p-sulphonate | 254-911-5 | 40412-06-4 | Genetic toxicity in vivo | 06/09/2018 | 22/10/2018 | Details | |
2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl phenyl carbonate | 248-882-8 | 28173-59-3 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
2-[(2-methyl-1-oxoallyl)oxy]ethyl acetoacetate | 244-311-1 | 21282-97-3 | Genetic toxicity in vivo | 29/04/2014 | 13/06/2014 | Details | |
2-[2-(2-hydroxyethoxy)ethoxy]ethanol,methanesulfonic acid | 817-828-0 | 80322-82-3 | Genetic toxicity in vivo | 30/06/2023 | 14/08/2023 | Details | |
2-dibutylaminoethanol | 203-057-1 | 102-81-8 | Genetic toxicity in vivo | 21/03/2014 | 05/05/2014 | Details | |
2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate | 403-960-2 | - | Genetic toxicity in vivo | 03/10/2023 | 17/11/2023 | Details | |
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 248-227-6 | 27107-89-7 | Genetic toxicity in vivo | 30/11/2015 | 14/01/2016 | Details | |
2-methoxyethyl acrylate | 221-499-3 | 3121-61-7 | Genetic toxicity in vivo | 21/03/2014 | 05/05/2014 | Details | |
2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar-heptyl ar',ar''-Me derivs. | 296-120-8 | 92257-31-3 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
2-tert-butyl-1,4-dimethoxybenzene | 244-216-5 | 21112-37-8 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
3,4,5,6,7,8,9,10,11,12,13,14-dodecahydro-2H-cyclododeca[b]pyran | 251-090-5 | 32539-83-6 | Genetic toxicity in vivo | 14/02/2011 | 31/03/2011 | Details | |
3,4-dihydroxybenzonitrile | 241-367-9 | 17345-61-8 | Genetic toxicity in vivo | 17/06/2020 | 03/08/2020 | Details | |
3,5-bis(2,4-dimethylcyclohex-3-en-1-yl)polyheterocycle | - | - | Genetic toxicity in vivo | 16/03/2015 | 30/04/2015 | Details | |
3-(benzothiazol-2-yl)-7-(diethylamino)-2-oxo-2H-1-benzopyran-4-carbonitrile | 274-668-9 | 70546-25-7 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
3-(diethylamino)-7-oxo-7H-[1]benzopyrano[3',2':3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile | 257-884-8 | 52372-36-8 | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
3-(Trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate | 642-902-2 | 163802-53-7 | Genetic toxicity in vivo | 10/03/2017 | 25/04/2017 | Details | |