Previous Testing Proposals
Previous Testing Proposals
| Methyl benzoylformate | 239-263-3 | 15206-55-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 |
Details | |
| 1,6-Bis((dibenzylthiocarbamoyl)disulfanyl)hexane | 429-280-6 | 151900-44-6 | Reproductive toxicity (developmental toxicity) | 01/09/2010 | 15/10/2010 | Details | |
| A mixture of isomers of branched tetracosane | 417-060-2 | 151006-61-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 1-decene, dimer (EC 917-709-4), Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1) and 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9), 1-Dodecene, Dimer (EC 814-509-8 ) and Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) and 1-Dodecene, dimer, hydrogenated (EC 604-768-3) |
01/07/2021 01/07/2021 01/07/2021 |
16/08/2021 16/08/2021 16/08/2021 |
Details | |
| 1-Dodecene, dimer with 1-decene, hydrogenated | 604-766-2 | 151006-58-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1), 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) and 1-decene, dimer (EC 917-709-4) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1), 1-Dodecene, Dimer (EC 814-509-8) and 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) and 1-Dodecene, dimer, hydrogenated (EC 604-768-3) |
01/07/2021 01/07/2021 01/07/2021 |
16/08/2021 16/08/2021 16/08/2021 |
Details | |
| Aziridine | 205-793-9 | 151-56-4 | Long-term toxicity to fish | 26/01/2011 | 14/03/2011 | Details | |
| a,a-dimethylphenethyl acetate | 205-781-3 | 151-05-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/05/2017 17/05/2017 |
03/07/2017 03/07/2017 |
Details | |
| Mequinol | 205-769-8 | 150-76-5 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2011 | 14/06/2011 | Details | |
| Dichloro(methyl)(phenyl)silane | 205-746-2 | 149-74-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1) | 04/04/2014 | 19/05/2014 | Details | |
| Sodium hydroxymethanesulphinate | 205-739-4 | 149-44-0 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
| Sodium hydroxymethanesulphinate | 205-739-4 | 149-44-0 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
| bismuth oxide salicylate | 238-953-1 | 14882-18-9 | Sub-chronic toxicity (90 day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8) | 18/09/2014 | 03/11/2014 | Details | |
| Ethylenediamine, salt with phosphoric acid | 238-914-9 | 14852-17-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/01/2020 | 12/03/2020 | Details | |
| 3-(triethoxysilyl)propanethiol | 238-883-1 | 14814-09-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
| 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF | 216-036-7 | 1478-61-1 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
| 2-Oxetanone, 3-C12-16-alkyl-4-C13-17-alkylidene derivs., (4E)- | 939-401-9 | 1469983-41-2 | Long-term toxicity to fish ||Note: testing proposed with 2-Oxetanone, 3-C14-16-alkyl 4-C15-17-alkylidene derivs (EC no. 308-760-8) | 15/07/2022 | 29/08/2022 | Details | |
| Hexanoic acid, 3,5,5-trimethyl-, 2,2,6,6-tetramethyl-1-[2-[(3,5,5-trimethyl-1-oxohexyl)oxy]ethyl]-4-piperidinyl ester | 941-267-1 | 1445870-18-7 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2023 31/01/2023 31/01/2023 |
17/03/2023 17/03/2023 17/03/2023 |
Details | |
| N,N-dimethyldecan-1-amide | 238-405-1 | 14433-76-2 | Long-term toxicity to fish | 15/07/2011 | 29/08/2011 | Details | |
| 2,2,4-trimethylpentane-1,3-diol | 205-619-1 | 144-19-4 | Reproductive toxicity (pre-natal developmental toxicity) | 18/02/2014 | 04/04/2014 | Details | |
| Zinc bis(diethyldithiocarbamate) | 238-270-9 | 14324-55-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 10/08/2018 | 24/09/2018 | Details | |
| Bis(2-(2-butoxyethoxy)ethoxy)methane | 205-598-9 | 143-29-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
| bis(2-(2-butoxyethoxy)ethoxy)methane | 205-598-9 | 143-29-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
| 2-(2-(2-butoxyethoxy)ethoxy)ethanol | 205-592-6 | 143-22-6 | Reproductive toxicity (pre-natal developmental toxicity): 1st PNDT on the registered substance 2nd PNDT with the registered substance // Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6) | 27/01/2020 | 12/03/2020 | Details | |
| 2-(2-(2-butoxyethoxy)ethoxy)ethanol | 205-592-6 | 143-22-6 | Reproductive toxicity (pre-natal developmental toxicity) | 10/08/2018 | 24/09/2018 | Details | |
| Lithium tetrafluoroborate, anhydrous | 238-178-9 | 14283-07-9 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Alcohols, C6-8, ethoxylated | 800-182-9 | 1426148-68-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
28/11/2022 28/11/2022 |
12/01/2023 12/01/2023 |
Details | |
| sodium/triethanolamine 4-((2-hydroxyethyl)amino)-3-pentaproenyl-4-oxobutanoate | 800-765-8 | 1424149-03-0 | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2014 | 29/08/2014 | Details | |
| Dodecyl methacrylate | 205-570-6 | 142-90-5 | Sub-chronic toxicity (90-day): oral | 03/04/2023 | 22/05/2023 | Details | |
| Fatty acids, tall-oil, reaction products with fatty acids C16-C18 and C18-unsatd, branched and linear, diethylenetriamine and maleic anhydride | 806-508-6 | 1419212-77-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral
Note: testing proposed with substance Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride (CAS: 1419212-76-2) |
05/06/2014 05/06/2014 |
21/07/2014 21/07/2014 |
Details | |
| Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride | 800-430-6 | 1419212-76-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
05/06/2014 05/06/2014 |
21/07/2014 21/07/2014 |
Details | |
| (3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde | 801-656-8 | 1416808-92-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/04/2015 | 04/06/2015 | Details | |
| O-isopropyl ethylthiocarbamate | 205-517-7 | 141-98-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): oral |
16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 |
Details | |
| dodecamethylpentasiloxane | 205-492-2 | 141-63-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 |
Details | |
| dodecamethylpentasiloxane | 205-492-2 | 141-63-9 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Decamethyltetrasiloxane (EC 205-491-7). |
25/06/2015 | 10/08/2015 | Details | |
| decamethyltetrasiloxane | 205-491-7 | 141-62-8 | Reproductive toxicity (pre-natal developmental toxicity) | 16/10/2014 | 01/12/2014 | Details | |
| Trichloro(propyl)silane | 205-489-6 | 141-57-1 | Reproductive toxicity (pre-natal developmental toxicity) // Note: testing proposed with Triethoxy(propyl)silane (EC 219-842-7, CAS 2550-02-9) | 04/04/2014 | 19/05/2014 | Details | |
| Bis(2-butoxyethyl) adipate | 205-466-0 | 141-18-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| Bis(2-ethylhexyl) fumarate | 205-448-2 | 141-02-6 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish Sub-chronic toxicity (90-day): oral |
14/02/2011 14/02/2011 14/02/2011 |
31/03/2011 31/03/2011 31/03/2011 |
Details | |
| 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate | 925-259-5 | 140921-24-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 30/06/2014 |
Details | |
| 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate | 411-700-4 | 140921-24-0 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/05/2022 10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 27/06/2022 |
Details | |
| potassium tetrafluoroborate | 237-928-2 | 14075-53-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
| ((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene | 801-941-7 | 1404190-37-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
| ((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene | 801-941-7 | 1404190-37-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/10/2016 20/10/2016 |
05/12/2016 05/12/2016 |
Details | |
| Morpholine, 4-C12-14-alkyl derivs. | 800-906-3 | 1402434-48-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| Cobalt(II) 4-oxopent-2-en-2-olate | 237-855-6 | 14024-48-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| Cobalt(II) 4-oxopent-2-en-2-olate | 237-855-6 | 14024-48-7 |
"Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4)
|| Note: Testing proposal is based on concern identified by the registrant.
" Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
| 2-piperazin-1-ylethylamine | 205-411-0 | 140-31-8 |
Chronic toxicity/carcinogenicity Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
14/02/2011 14/02/2011 14/02/2011 |
31/03/2011 31/03/2011 31/03/2011 |
Details | |
| 2-piperazin-1-ylethylamine | 205-411-0 | 140-31-8 | Sub-chronic toxicity (90-day): oral | 21/10/2011 | 05/12/2011 | Details | |
| 2-piperazin-1-ylethylamine | 205-411-0 | 140-31-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/09/2017 | 16/10/2017 |
|
Details |
| Potassium dicyanoaurate | 237-748-4 | 13967-50-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
| hexahydrophthalic acid diglycidylester | 696-026-0 | 1395383-69-3 | Sub-chronic toxicity (90-day): oral | 16/10/2014 | 01/12/2014 | Details | |
| Reaction products of acrylic acid with 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] | 830-217-3 | 1393932-71-2 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated |
24/01/2019 24/01/2019 |
11/03/2019 11/03/2019 |
Details | |
| Fatty acids, tall-oil, reaction products with fatty acids C16-C18 and C18-unsatd, branched and linear, diethylenetriamine and citric acid | 806-510-7 | 1393571-43-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride (CAS number: 1419212-76-2, CAS name: Amides, tall-oil fatty, N, N’-(iminodi-2,1-ethanediyl)bis-, maleated) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride (CAS number: 1419212-76-2, CAS name: Amides, tall-oil fatty, N, N’-(iminodi-2,1-ethanediyl)bis-, maleated) |
05/06/2014 05/06/2014 |
21/07/2014 21/07/2014 |
Details | |
| Fatty acids, C16-18 and C18-unsatd., branched and linear, reaction products with diethylenetriamine and tall-oil fatty acids, Me maleates | 806-509-1 | 1393571-42-0 | Reproductive toxicity (pre-natal developmental toxicity) | 05/06/2014 | 21/07/2014 | Details | |
| Tetraammineplatinum dichloride | 237-706-5 | 13933-32-9 | Genetic toxicity in vivo | 25/11/2021 | 10/01/2022 | Details | |
| Tetraammineplatinum dichloride | 237-706-5 | 13933-32-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 28/02/2018 | 16/04/2018 | Details | |
| Bis(dibutyldithiocarbamato-S,S')copper | 237-695-7 | 13927-71-4 | Long-term toxicity to fish | 22/06/2017 | 07/08/2017 | Details | |
| Disodium dihydrogen 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate | 205-358-3 | 139-33-3 | Sub-chronic toxicity (90 day): inhalation | 16/06/2011 | 01/08/2011 | Details | |
| Cesium fluoroaluminate | 604-086-6 | 138577-01-2 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
| 3-(trimethoxysilyl)propylamine | 237-511-5 | 13822-56-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
| 3,5-dimethyl-1,2-dioxolane-3,5-diol | 237-438-9 | 13784-51-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/09/2017 01/09/2017 |
16/10/2017 16/10/2017 |
Details | |
| Sodium metavanadate | 237-272-7 | 13718-26-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
25/01/2022 25/01/2022 |
11/03/2022 11/03/2022 |
Details | |
| Magnesium metaborate | 237-235-5 | 13703-82-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/11/2021 | 10/01/2022 | Details | |
| Divanadium tris(sulphate) | 237-226-6 | 13701-70-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7) |
30/06/2023 30/06/2023 |
14/08/2023 14/08/2023 |
Details | |
| Barium diboron tetraoxide | 237-222-4 | 13701-59-2 | Reproductive toxicity (two-generation reproductive toxicity) | 16/05/2014 | 30/06/2014 | Details | |
| Sodium N-lauroylsarcosinate | 205-281-5 | 137-16-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
| Sodium N-lauroylsarcosinate | 205-281-5 | 137-16-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
| Sodium N-lauroylsarcosinate | 205-281-5 | 137-16-6 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: Note: testing proposed with N-methyl-N-[C18-(unsaturated)alkanoyl]glycine (EC no. 701-177-3) | 30/06/2023 | 14/08/2023 | Details | |
| 4,4'-methylenebis[2,6-diethylaniline] | 237-185-4 | 13680-35-8 |
Genetic toxicity in vivo Long-term toxicity to fish |
26/03/2018 26/03/2018 |
11/05/2018 11/05/2018 |
Details | |
| 1,1'-(methylenedi-p-phenylene)bismaleimide | 237-163-4 | 13676-54-5 | Reproductive toxicity (pre-natal developmental toxicity) | 30/09/2021 | 15/11/2021 | Details | |
| Cobalt bis(2-ethylhexanoate) | 205-250-6 | 136-52-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| Cobalt bis(2-ethylhexanoate) | 205-250-6 | 136-52-7 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4)
|| Note: Testing proposal is based on concern identified by the registrant. Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
| Stearic acid, cobalt salt | 237-016-4 | 13586-84-0 | Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Neodecanoic acid, cobalt salt (EC no. 248-373-0) | 28/11/2022 | 12/01/2023 | Details | |
| Stearic acid, cobalt salt | 237-016-4 | 13586-84-0 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) | 21/01/2021 | 08/03/2021 | Details | |
| Copolymer of benzenamine and formaldehyde, hydrogenated | 603-894-6 | 135108-88-2 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |
| Alkane-alpha,omega-diyl bis{[(trimethoxysilyl)propyl]carbamate}_M2 | 700-904-1 | 1350725-68-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl [3-(trimethoxysilyl) propyl]carbamate CAS 23432-62-4 | 02/11/2018 | 17/12/2018 | Details | |
| (3-chloropropyl)diethoxymethylsilane | 236-828-6 | 13501-76-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3) | 17/04/2015 | 04/06/2015 | Details | |
| Bis(triethoxysilylpropyl)amine | 236-818-1 | 13497-18-2 | Sub-chronic toxicity (90-day): oral | 22/09/2022 | 07/11/2022 | Details | |
| Bis(triethoxysilylpropyl)amine | 236-818-1 | 13497-18-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Bis(trimethoxysilylpropyl)amine (EC 403-480-3) || Note: Testing proposal is based on concern identified by the registrant | 07/07/2020 | 21/08/2020 | Details | |
| 2,2'-azobis[2-methylbutyronitrile] | 236-740-8 | 13472-08-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 17/04/2014 |
Details | |
| Raffinates (Fischer-Tropsch), C10-25-branched | - | 1345668-40-7 | Reproductive toxicity (two-generation reproductive toxicity) | 17/08/2012 | 01/10/2012 | Details | |
| Aluminium oxide | 215-691-6 | 1344-28-1 | Genetic toxicity in vivo || Note: Testing proposal for two in vivo studies is based on concern identified by the registrant. Testing proposed with Aluminium oxide nanoscale material. | 28/02/2018 | 16/04/2018 | Details | |
| (octadecanoato-O)oxoaluminium | 236-521-7 | 13419-15-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) | 30/11/2015 | 14/01/2016 | Details | |
| 2,2'-[(1-methylethylidene)bis(cyclohexane-4,1-diyloxymethylene)]bisoxirane | 236-502-3 | 13410-58-7 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
| tetradecahydro-7-isopropyl-1,4a-dimethylphenanthren-1-methanol | 236-476-3 | 13393-93-6 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 |
Details | |
| Naphthenic acids | 215-662-8 | 1338-24-5 | Long-term toxicity to fish | 01/07/2011 | 15/08/2011 | Details | |
| Naphthenic acids | 215-662-8 | 1338-24-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
| Dioxydibutane-2,2-diyl dihydroperoxide | 215-661-2 | 1338-23-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 |
Details | |
| Reaction mass of butane-2,2-diyl dihydroperoxide and di-sec-butylhexaoxidane | 700-954-4 | 1338-23-4 | Sub-chronic toxicity (90-day): oral | 19/12/2013 | 03/02/2014 | Details | |
| Sodium diisobutyldithiophosphinate | 236-419-2 | 13360-78-6 |
Reproductive toxicity (pre-natal developmental toxicity) with Rat Sub-chronic toxicity (90-day): oral |
24/07/2019 24/07/2019 |
09/09/2019 09/09/2019 |
Details | |
| boron orthophosphate | - | 13308-51-5 | Reproductive toxicity (pre-natal developmental toxicity) | 30/06/2016 | 15/08/2016 |
|
Details |
| Tris(methylphenyl) phosphate | 215-548-8 | 1330-78-5 |
Bioaccumulation: aquatic / sediment; Long-term toxicity to fish |
02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 |
Details | |
| Xylene | 215-535-7 | 1330-20-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC no. 905-588-0) | 31/01/2023 | 17/03/2023 | Details | |
| Xylene | 215-535-7 | 1330-20-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC No 905-588-0) | 01/03/2023 | 17/04/2023 | Details | |
| bis(2,4-dichlorobenzoyl) peroxide | 205-094-9 | 133-14-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/03/2014 21/03/2014 |
05/05/2014 05/05/2014 |
Details | |
| 5-amino-2-nitrobenzoic acid | 236-283-4 | 13280-60-9 | Genetic toxicity in vivo | 25/01/2022 | 11/03/2022 | Details | |
| N-octadecylstearamide | 236-276-6 | 13276-08-9 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) |
17/04/2015 17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 04/06/2015 |
Details | |
| Zinc methacrylate | 236-144-8 | 13189-00-9 | Genetic toxicity in vivo | 01/03/2023 | 17/04/2023 | Details | |
| Cobalt sulphide | 215-273-3 | 1317-42-6 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
| Cobalt sulphide | 215-273-3 | 1317-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| N-vinylformamide | 236-102-9 | 13162-05-5 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 |
Details | |
| N-vinylformamide | 236-102-9 | 13162-05-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/11/2015 | 16/12/2015 | Details | |
| Divanadium pentaoxide | 215-239-8 | 1314-62-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
| Ytterbium (III) oxide | 215-234-0 | 1314-37-0 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
| Zirconium dioxide | 215-227-2 | 1314-23-4 | Reproductive toxicity (pre-natal developmental toxicity) | 15/04/2011 | 30/05/2011 | Details | |
| Strontium oxide | 215-219-9 | 1314-11-0 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2019 | 09/08/2019 | Details | |
| Manganese dioxide | 215-202-6 | 1313-13-9 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
| 1-Octadecanamine, reaction products with 1,1'-methylenebis[4-isocyanatobenzene] and 1-octanamine | 812-491-6 | 1312943-23-9 | Long-term toxicity to fish || Note: testing proposed with Reaction mass of 4,4'-methylenediphenyl diisocyanate and Amines, soya alkyl (EC no. 905-837-3) and Reaction product of 4,4'-methylenediphenyl diisocyanate (MDI) , Octylamine) and Hexamethylenediamine (EC no. 924-670-7) | 26/08/2021 | 11/10/2021 | Details | |
| 1-Dodecanamine, reaction products with 1,1'-methylenebis[4-isocyanatobenzene] and 1-octanamine | 812-490-0 | 1312943-21-7 | Long-term toxicity to fish || Note: testing proposed with Reaction mass of 4,4'-methylenediphenyl diisocyanate and Amines, soya alkyl (EC no. 905-837-3) and Reaction product of 4,4'-methylenediphenyl diisocyanate (MDI) (Octylamine and Hexamethylenediamine (EC no. 924-670-7) | 26/08/2021 | 11/10/2021 | Details | |
| tert-butyl 3,5,5-trimethylperoxyhexanoate | 236-050-7 | 13122-18-4 | Genetic toxicity in vivo | 18/02/2021 | 05/04/2021 | Details | |
| tert-butyl 3,5,5-trimethylperoxyhexanoate | 236-050-7 | 13122-18-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
| Lithium hydroxide | 215-183-4 | 1310-65-2 | Reproductive toxicity (two-generation reproductive toxicity) | 29/04/2011 | 14/06/2011 | Details | |
| 2,4-dihydroxybenzophenone | 205-029-4 | 131-56-6 | Genetic toxicity in vivo | 03/10/2023 | 17/11/2023 | Details | |
| Tricobalt tetraoxide | 215-157-2 | 1308-06-1 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Cobalt sulphide (EC 215-273-3)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
| Tricobalt tetraoxide | 215-157-2 | 1308-06-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| Cobalt oxide | 215-154-6 | 1307-96-6 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4) Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2) |
21/01/2021 21/01/2021 |
08/03/2021 08/03/2021 |
Details | |
| Cobalt oxide | 215-154-6 | 1307-96-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| 1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) | 235-935-5 | 13052-09-0 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 12/12/2014 | 26/01/2015 | Details | |
| 1,10-decanediyl diacrylate | 235-922-4 | 13048-34-5 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| bismuth hydroxide nitrate oxide | 215-136-8 | 1304-85-4 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
| Dibismuth trioxide | 215-134-7 | 1304-76-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 |
Details | |
| Sodium xylenesulphonate | 215-090-9 | 1300-72-7 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2014 | 29/08/2014 | Details | |
| Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate | 403-530-4 | 129423-54-7 | 7.8.2 Developmental toxicity / teratogenicity | 08/03/2024 | 22/04/2024 | Details | |
| (1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol | 695-878-0 | 1283129-18-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 2,6-di-tert-butylphenol | 204-884-0 | 128-39-2 | Sub-chronic toxicity (90-day): oral | 16/05/2011 | 30/06/2011 | Details | |
| 2,6-di-tert-butylphenol | 204-884-0 | 128-39-2 | Bioaccumulation aquatic / sediment | 04/12/2023 | 18/01/2024 |
|
Details |
| 2,6-di-tert-butylphenol | 204-884-0 | 128-39-2 | Reproductive toxicity (pre-natal developmental toxicity) | 17/06/2020 | 03/08/2020 | Details | |
| Phosphoric acid, butyl ester | 235-826-2 | 12788-93-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 |
Details | |
| Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. |
25/11/2019 | 09/01/2020 | Details | |
| Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Carcinogenicity study Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2011 29/04/2011 29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 14/06/2011 14/06/2011 |
Details | |
| Hexadecyldimethylamine | 695-101-5 | 1275611-65-8 | Reproductive toxicity (pre-natal developmental toxicity) | 23/04/2018 | 07/06/2018 | Details | |
| Dichlorobis(η-cyclopentadienyl)titanium | 215-035-9 | 1271-19-8 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Diphenyl sulphone | 204-853-1 | 127-63-9 | Reproductive toxicity (pre-natal developmental toxicity) | 18/02/2014 | 04/04/2014 | Details | |
| Phosphoric acid, 2-ethylhexyl ester | 235-741-0 | 12645-31-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
| 2,2,2',2'-Tetrakis(hydroxymethyl)-3,3'-oxydipropan-1-ol | 204-794-1 | 126-58-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/04/2022 | 16/05/2022 | Details | |
| 2,2,2`,2`-Tetrakis(hydroxymethyl)-3,3`-oxydipropan-1-ol | 204-794-1 | 126-58-9 | Reproductive toxicity (pre-natal developmental toxicity) | 15/03/2011 | 29/04/2011 | Details | |
| 2-ethyl-2-[[(1-oxononyl)oxy]methyl]propane-1,3-diyl dinonan-1-oate | 204-793-6 | 126-57-8 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 17/04/2015 | 04/06/2015 | Details | |
| Tetrahydrothiophene 1,1-dioxide | 204-783-1 | 126-33-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) / Testing proposal is based on concern identified by the registrant. | 23/04/2018 | 07/06/2018 | Details | |
| Tetrahydrothiophene 1,1-dioxide | 204-783-1 | 126-33-0 | Reproductive toxicity (two-generation reproductive toxicity) | 29/04/2011 | 14/06/2011 | Details | |
| Dimethylpropane-1,3-diol | 204-781-0 | 126-30-7 |
Reproductive toxicity (developmental toxicity) Sub-chronic toxicity (90-day) |
26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 |
Details | |
| Aromatic hydrocarbons, C10-13, reaction products with branched nonene, sulfonated, sodium salts | 800-660-7 | 1258274-08-6 | Reproductive toxicity (pre-natal developmental toxicity) | 23/01/2015 | 09/03/2015 | Details | |
| Pleuromulin | 204-747-5 | 125-65-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/09/2018 06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 22/10/2018 |
Details | |
| Dimethylamine | 204-697-4 | 124-40-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2018 | 16/04/2018 | Details | |
| Decane | 204-686-4 | 124-18-5 | Reproductive toxicity (two-generation reproductive toxicity) | 25/06/2012 | 09/08/2012 | Details | |
| Adipic acid | 204-673-3 | 124-04-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 18/02/2021 | 05/04/2021 | Details | |
| tetraammine platinum (II) hydrogen carbonate | 426-730-3 | 123439-82-7 | Genetic toxicity in vivo|| Note: Testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. | 25/10/2017 | 11/12/2017 | Details | |
| C,C'-azodi(formamide) | 204-650-8 | 123-77-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/11/2021 | 10/01/2022 | Details | |
| 4-oxovaleric acid | 204-649-2 | 123-76-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
| Pentane-2,4-dione | 204-634-0 | 123-54-6 |
Long-term toxicity to fish Reproductive toxicity (two-generation reproductive toxicity) |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
| 3-methylbutan-1-ol | 204-633-5 | 123-51-3 | Long-term toxicity to fish||Note: testing proposed with Pentan-1-ol (EC no. 200-752-1) | 22/09/2022 | 07/11/2022 | Details | |
| 4-hydroxy-4-methylpentan-2-one | 204-626-7 | 123-42-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/09/2016 01/09/2016 |
17/10/2016 17/10/2016 |
Details | |
| Choline hydroxide | 204-625-1 | 123-41-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Choline chloride (EC 200-655-4) | 25/05/2020 | 09/07/2020 | Details | |
| N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) | 204-613-6 | 123-26-2 |
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with: “Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine”, CAS 100545-48-0 Sub-chronic toxicity (90 day): oral |
30/09/2015 30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 16/11/2015 |
Details | |
| Amides, fatty acids C18 unsat, reaction products with polyethylene amines | 629-735-0 | 1226892-50-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| Fatty acids C18 unsat, reaction products with tetraethylenepentamine | 629-725-6 | 1226892-45-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| Fatty acids C18 unsat, reaction products with triethylenetetramine | 629-765-4 | 1226892-44-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| Fatty acids, C18-unsatd., reaction products with diethylenetriamine | 629-715-1 | 1226892-43-8 | Long-term toxicity to fish | 26/10/2022 | 12/12/2022 | Details | |
| Cyclohexanone, peroxide | 235-527-7 | 12262-58-7 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
| Amides, Fatty acids C18 unsaturated, reaction products with tetraethylenepentamine | 630-459-8 | 1225197-81-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| Fatty acids, C18 unsaturated, reaction product with ammonia-ethanolamine reaction by-products | 629-757-0 | 1224966-15-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide | 235-425-2 | 12225-06-8 |
7.5.2 Repeated dose toxicity: inhalation 7.8.2 Developmental toxicity / teratogenicity |
08/03/2024 08/03/2024 |
22/04/2024 22/04/2024 |
Details | |
| Diamminediisocyanatozinc | 401-610-3 | 122012-52-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
| 4-phenylbutenone | 204-555-1 | 122-57-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine | 628-863-4 | 1219458-14-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/01/2019 | 11/03/2019 | Details | |
| N-(3-aminopropyl)-N`-[3-(C16-18 (evennumbered), C18 unsaturated alkyl amino)propyl]propane-1,3-diamine | 628-862-9 | 1219458-11-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
| reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated | 846-447-2 | 1219458-07-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Cobalt lithium dioxide | 235-362-0 | 12190-79-3 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
| 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,2'-(Octadec-9-enylimino) bisethanol, CAS No 25307-17-9 | 14/03/2016 | 28/04/2016 |
|
Details |
| Copper hydroxide nitrate | 439-590-3 | 12158-75-7 | Reproductive toxicity (pre-natal developmental toxicity) | 03/11/2011 | 19/12/2011 | Details | |
| N,N,N`,N`,N``-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride | 629-716-7 | 1211950-04-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
| Trimethyl borate | 204-468-9 | 121-43-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with boric acid. Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with boric acid. Sub-chronic toxicity (90-day): oral || Note: testing proposed with boric acid. |
15/04/2014 15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 30/05/2014 |
Details | |
| 4-nitrotoluene-2-sulphonic acid | 204-445-3 | 121-03-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
| potassium titanium oxide (K2Ti6O13) | 432-240-0 | 12056-51-8 | Long-term toxicity to fish | 17/05/2017 | 03/07/2017 | Details | |
| α-methyl-1,3-benzodioxole-5-propionaldehyde | 214-881-6 | 1205-17-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 31/01/2023 | 17/03/2023 | Details | |
| barium titanium trioxide | 234-975-0 | 12047-27-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 |
Details | |
| 4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| praseodymium(III,IV) oxide | 234-857-9 | 12037-29-5 | Genetic toxicity in vivo | 18/09/2014 | 03/11/2014 | Details | |
| Vanadium dioxide | 234-841-1 | 12036-21-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: : testing proposed with Sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
| Cobalt hydroxide oxide | 234-614-7 | 12016-80-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| Cobalt hydroxide oxide | 234-614-7 | 12016-80-7 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Cobalt sulphide (EC 215-273-3)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
| 2-imidazolidone | 204-436-4 | 120-93-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
| 1,2-dihydroxybenzene,pyrocatechol | 204-427-5 | 120-80-9 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
| 1,3-diphenylpropane-1,3-dione | 204-398-9 | 120-46-7 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 03/11/2014 |
Details | |
| Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts | 601-601-6 | 119345-04-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| 1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (two-generation reproductive toxicity) | 16/06/2011 | 01/08/2011 | Details | |
| 1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
| 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol | 204-327-1 | 119-47-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
| 6,6`-di-tert-butyl-2,2`-methylenedi-p-cresol | 204-327-1 | 119-47-1 | Reproductive toxicity (two-generation reproductive toxicity) | 16/05/2011 | 30/06/2011 | Details | |
| Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide | 810-703-1 | 1187441-10-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| Trifluoro(trifluoromethoxy)ethylene | 214-703-7 | 1187-93-5 | Sub-chronic toxicity (90 day): inhalation | 29/04/2014 | 13/06/2014 | Details | |
| Trimethoxy(methyl)silane | 214-685-0 | 1185-55-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study Reproductive toxicity (pre-natal developmental toxicity) |
12/04/2017 12/04/2017 |
29/05/2017 29/05/2017 |
Details | |
| Trimethylamine, N-oxide | 214-675-6 | 1184-78-7 | Genetic toxicity in vivo||Note: testing proposed with Reference substance 001 [CAS No. 62637-93-8] | 06/06/2023 | 21/07/2023 | Details | |
| 2,4,6-trinitrotoluene | 204-289-6 | 118-96-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation |
04/04/2014 04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 19/05/2014 |
Details | |
| Ureidopropyltrialkoxysilane | 449-160-7 | 116912-64-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
| 4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] | 601-409-2 | 116020-44-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
| Alcohols, C18-22, distn. residues | 641-136-6 | 1160164-88-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
| 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | 116-37-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/07/2015 | 14/09/2015 | Details | |
| 1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | 116-37-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
| Hydroxyacetone | 204-124-8 | 116-09-6 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
| 4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco | 500-303-2 | 115340-85-7 | Genetic toxicity in vivo | 21/01/2021 | 08/03/2021 | Details | |
| Linalyl acetate | 204-116-4 | 115-95-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/06/2020 | 03/08/2020 | Details | |