Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

There are currently no ongoing consultations.
 
inorganic phosphorus salt 428-310-5 - Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018 Details
isliFe - - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 17/12/2019 31/01/2020 Details
Itaconic acid 202-599-6 - Reproductive toxicity (two-generation reproductive toxicity) 16/01/2012 01/03/2012 Details
LiFePO4 476-700-9 - Reproductive toxicity (pre-natal developmental toxicity) 22/10/2013 05/12/2013 Details
Lithium bis(oxalato)borate 456-990-3 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Details
Magnesium, bis(2-hydroxybenzoato-O1,O2)-, ar,ar'-di-C14-18alkyl derivs 931-371-5 - Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018 Details
Methylene-bis-4,1-(N-phenylene-N'-butylurea) 416-600-4 - Bioaccumulation aquatic / sediment 17/05/2016 01/07/2016 Details
Middle distillate from refinery proces cofeeding vegetable oil 938-793-9 - Reproductive toxicity (two-generation reproductive toxicity) 02/09/2013 18/10/2013 Details
Mono- and/or di- and/or tri(1-phenylethyl)-m-cresol and p-cresol 700-427-9 -
Reproductive toxicity (developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
01/12/2010
01/12/2010
01/12/2010
17/01/2011
17/01/2011
17/01/2011
Details
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide 419-710-0 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
12/12/2014
12/12/2014
12/12/2014
26/01/2015
26/01/2015
26/01/2015
Details
N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine, N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl-, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl-, 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl-(Mixture) 939-700-4 - Sub-chronic toxicity (90-day): oral 21/10/2019 05/12/2019 Details
N,N-dimethyl-alkyl-1-amines, reaction products with alkali hydroxide and chloroacetic acid 939-682-8 -
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
N-(2-nitrophenyl)phosphoric triamide 477-690-9 - Long-term toxicity to fish 18/03/2021 03/05/2021 Details
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine 628-863-4 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
12/09/2011
12/09/2011
Details
N-(C16-C18)alkyl(C16-C18)alkane-1-amine 629-721-4 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
16/06/2011
01/08/2011
01/08/2011
01/08/2011
Details
N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide; N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide 700-208-8 - Sub-chronic toxicity (90-day): oral 04/10/2018 19/11/2018 Details
N-[2-(piperazin-1-yl)ethyl]C18-unsatured-alkylamide 629-767-5 -
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
Details
N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride - -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
12/09/2011
12/09/2011
Details
n-methyl-n-[c18-(unsaturated)alkanoyl]glycine 701-177-3 - Reproductive toxicity (extended one-generation reproductive toxicity study) 21/10/2021 07/12/2021 Details
N-Phenyl-diethanolamine, reaction products with formaldehyde 942-131-4 - Genetic toxicity in vivo 26/08/2021 11/10/2021 Details
N-Phenyl-diethanolamine, reaction products with formaldehyde 942-131-4 - Reproductive toxicity (pre-natal developmental toxicity) 21/10/2021 07/12/2021 Details
N-{3-[C12-14-(even numbered)-alkyloxy]propyl}propane-1,3-diamine 701-437-6 - Sub-chronic toxicity (90-day): oral|| Note: testing proposed with [1,3-propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]-branched acetate (EC no 931-295-2) 15/07/2022 29/08/2022 Details
Nickel, 5,5'-azobis-2,4,6(1H,3H,5H)-pyrimidinetrione complexes and melamine 939-379-0 - Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
Nonanoic acid (branched), 2-oxiranylmethyl ester 940-029-4 -
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2,3-epoxypropyl neodecanoate (EC No. 247-979-2)
20/09/2013
20/09/2013
20/09/2013
04/11/2013
04/11/2013
04/11/2013
Details
O,O-di(1-methylethyl)trithio-bis-thioformate,O,O-di(1-methylethyl)tetrathio-bis-thioformate,O,O-di(1-methylethyl)pentathio-bis-thioformate 403-030-6 - Reproductive toxicity (pre-natal developmental toxicity) 24/05/2013 08/07/2013 Details
Octadecanoic acid, 12-hydroxy-, reaction products with decanoic acid and ethylenediamine 907-495-0 -
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study)
01/04/2022
01/04/2022
16/05/2022
16/05/2022
Details
Octadecanoic acid, sulfonated, potassium salt 701-179-4 - Sub-chronic toxicity (90-day): oral || Note: The List number has changed. 31/01/2018 19/03/2018 Details
Octadecylamine, reaction products with 4,4'-methylenediphenyl diisocyanate 928-226-3 - Sub-chronic toxicity (90-day): oral 16/10/2014 01/12/2014 Details
Octanethioic acid, S-[3-(triethoxysilyl)propyl] ester, reaction products with 2-methyl-1,3-propanediol and 3-(triethoxysilyl)-1-propanethiol 485-270-1 - Genetic toxicity in vivo 10/05/2022 27/06/2022 Details
Octanethioic acid, S-[3-(triethoxysilyl)propyl] ester, reaction products with 2-methyl-1,3-propanediol and 3-(triethoxysilyl)-1-propanethiol 485-270-1 -
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
28/11/2022
28/11/2022
28/11/2022
12/01/2023
12/01/2023
12/01/2023
Details
Pentaerythritol, reaction product with fatty acids, C8 to 18 (even numbered) and/or branched and/or unsaturated 484-420-3 - Reproductive toxicity (pre-natal developmental toxicity) 30/04/2012 14/06/2012 Details
pentasodium 4-amino-3-[{4-[(2,4-disulfonatophenyl)diazenyl]-3-methylphenyl}diazenyl]-5-hydroxy-6-[(4-nitro-2-sulfonatophenyl)diazenyl]naphthalene-1,7-disulfonate 948-569-2 - Genetic toxicity in vivo 01/04/2022 16/05/2022 Details
Pentyl 2-cyano-(3-(6-methoxybenzothiazol-2-ylimino)-2,3-dihydro-1H-isoindol-1-ylidene)acetate 436-060-3 - Genetic toxicity in vivo 26/10/2022 12/12/2022 Details
Petroleum diesel/gas oil fraction, co-processed with renewable hydrocarbons derived from thermally cracked plastics 941-803-4 -
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9) ||Note: testing proposed with Fuels, diesel (EC no. 269-822-7) ||Note: testing proposed with Fuel oil, no. 4 (EC no. 270-673-5) ||Note: testing proposed with Distillates (petroleum), light hydrocracked (EC no. 265-078-2)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9)
26/10/2022
26/10/2022
26/10/2022
12/12/2022
12/12/2022
12/12/2022
Details
Phosphoric acid, C11-14 (C13-rich)-isoalkyl mono- and di-esters, partially salted with 1-Propanamine, 3-(tridecyloxy)-, branched 947-480-6 - Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
plastic, waste, pyrolized, fractionation bottoms (raw diesel) 942-177-5 - Genetic toxicity in vivo 10/05/2022 27/06/2022 Details
Platinum(IV) aqua hydroxo nitrato complexes 701-319-4 - Genetic toxicity in vivo 25/05/2020 09/07/2020 Details
platinum(IV) nitrate/nitric acid solution 432-400-1 - Genetic toxicity in vivo 26/08/2021 11/10/2021 Details
Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexes 701-315-2 - Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. 25/05/2020 09/07/2020 Details
Polar modified Rice Bran Wax - - Reproductive toxicity (pre-natal developmental toxicity) 03/05/2023 19/06/2023 Details
Poly(alkan-2-yl)heteropolycycle - - Genetic toxicity in vivo 31/01/2013 18/03/2013 Details
Poly-(1,4-diisopropylbenzol) 449-400-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
Poly[oxy(methyl-1,2-ethanediyl)], .alapha.,α'-(2,2-dimethyl-1,3-propanediyl)bis[ω-[(1-oxo-2-propenyl)oxy 701-440-2 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/10/2022
26/10/2022
12/12/2022
12/12/2022
Details
Polyamide wax 434-430-9 - Long-term toxicity to fish 07/07/2020 21/08/2020 Details
Polysulfides, bis[3-(triethoxysilyl)propyl] 915-673-4 - Sub-chronic toxicity (90-day): oral 21/10/2021 07/12/2021 Details
Polysulfides, bis[3-(triethoxysilyl)propyl] 915-673-4 - Reproductive/developmental toxicity 22/12/2010 07/02/2011 Details
Polysulfides, bis[3-(triethoxysilyl)propyl] 915-673-4 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/07/2011
15/07/2011
29/08/2011
29/08/2011
Details
Polysulfides, bis[3-(triethoxysilyl)propyl] 915-673-4 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2018
28/02/2018
16/04/2018
16/04/2018
Details
Polysulfo {5-hydroxy-1-naphthalen-2-yl-[4-[4-(2-sulfatoethyl-sulfonyl)-phenyl]diazenyl]-1H-pyrazole-3-carboxylic acid}, alkali metal salt - - Genetic toxicity in vivo 09/11/2009 24/12/2009 Details
Potassium salts of {hexane-1,6-diylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1)  701-184-1 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Details
Product of Semi-Dry Absorption method of Flue Gas Desulphurization (SDA Product) 931-259-6 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
02/09/2011
02/09/2011
17/10/2011
17/10/2011
Details
Propionaldehyde, reaction product with formaldehyde 701-281-9 - Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. 10/12/2018 24/01/2019 Details
Propylidynetrimethanol, propoxylated 500-041-9 -
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with analogue substance
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with analogue substance
Sub-chronic toxicity (90-day): oral || Note: testing proposed with analogue substance
05/07/2018
05/07/2018
05/07/2018
20/08/2018
20/08/2018
20/08/2018
Details
Reaction mass of (2-azaniumylethyl)[3-(trimethoxysilyl)propyl]amine chloride (2-azaniumylethyl)(benzyl)[3-(trimethoxysilyl)propyl]amine chloride 3,3-dimethoxy-11-phenyl-2-oxa-7,10-diaza-3-silaundecan-7-ium chloride 7-benzyl-3,3-dimethoxy-11-phenyl-2-oxa-7,10-diaza-3-silaundecan-10-ium chloride 10-benzyl-3,3-dimethoxy-11-phenyl-2-oxa-7,10-diaza-3-silaundecan-7-ium chloride 7,10-dibenzyl-3,3-dimethoxy-11-phenyl-2-oxa-7,10-diaza-3-silaundecan-7-ium chloride 700-961-2 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
Details
Reaction mass of (4R)-isopropenyl-1-methylcyclohexene and (4S)-isopropenyl-1-methylcyclohexene and 1-isopropyl-4-methylcyclohexa-1,3-diene and 1-isopropyl-4-methylcyclohexa-1,4-diene and 4-isopropylidene-1-methylcyclohexene  905-474-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/10/2023
03/10/2023
17/11/2023
17/11/2023
Details
Reaction mass of 1,3-dioxane-5,5-dimethanol and 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- 911-819-6 - Long-term toxicity to fish 31/01/2023 17/03/2023 Details
Reaction mass of 1,3-Propanediamine, N-[3-(tridecyloxy)propyl]-, branched and 1,3-Propanediamine, N-[3-(tridecyloxy)propyl]-, branched acetate 931-295-2 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Details
Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol 911-819-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
Details
Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol 911-819-6 -
Reproductive toxicity (developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/02/2011
14/02/2011
31/03/2011
31/03/2011
Details
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane 608-489-8 - Genetic toxicity in vivo 03/02/2016 21/03/2016 Details
Reaction mass of 1-(C12-18-(even numbered))-alkyl-tetrahydropyrimidin-2(1H)-imine acetate salt and 1-(3-((C12-18-(even numbered))-alkyl-amino)propyl)guanidine acetate salt and 1-(C12-18-(even numbered))-alkyl-1-(3-guanidinopropyl)guanidine acetate salt 939-650-3 - Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
Reaction mass of 1-(C12-18-(even numbered))-alkyl-tetrahydropyrimidin-2(1H)-imine acetate salt and 1-(3-((C12-18-(even numbered))-alkyl-amino)propyl)guanidine acetate salt and 1-(C12-18-(even numbered))-alkyl-1-(3-guanidinopropyl)guanidine acetate salt 939-650-3 - Sub-chronic toxicity (90-day): oral 10/05/2022 27/06/2022 Details
Reaction mass of 1-[2-(2-aminobutoxy)ethoxy]but-2-ylamine and 1-({[2-(2-aminobutoxy)ethoxy]methyl}propoxy)but-2-ylamine 447-920-2 - Reproductive toxicity (pre-natal developmental toxicity) 21/05/2018 05/07/2018 Details
Reaction mass of 1-chlorobut-2-ene and 3-chlorobut-1-ene 908-820-9 - Genetic toxicity in vivo 16/07/2012 30/08/2012 Details
Reaction mass of 1-methyl-4-(1-methylethylidene)cyclohexyl acetate and p-menth-1-en-8-yl acetate 904-693-9 - Reproductive toxicity (extended one-generation reproductive toxicity study) 04/09/2023 19/10/2023 Details
Reaction mass of 1-phenyloctadecane-1,3-dione and phenylicosane-1,3-dione 915-316-2 - Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012 Details
Reaction mass of 2,2',2''-nitrilotriethanol and disodium succinate and sodium acetate and sodium bromide 905-908-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/03/2014
21/03/2014
05/05/2014
05/05/2014
Details
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019 Details
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/11/2014
18/11/2014
02/01/2015
02/01/2015
Details
Reaction mass of 2,2'-oxydibutane and 2-methylpropan-2-ol and butan-2-ol and 2,2'-oxydipropane 903-919-3 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
29/07/2011
29/07/2011
29/07/2011
12/09/2011
12/09/2011
12/09/2011
Details
Reaction mass of 2,2'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxymethylene]}dioxirane and 1,3-bis{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol and 3,3'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxy]}bis(1-{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol) 941-357-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) 21/10/2019 05/12/2019 Details
Reaction mass of 2,4,6,8,10-pentamethyl-2,4,6,8,10-pentavinylcyclopentasiloxane and 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 911-381-6 - Long-term toxicity to fish || Note: testing proposed with 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (EC 219-863-1) || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020 Details
Reaction mass of 2,5,8,11-tetraoxatridecan-13-ol and 2,5,8,11,14-pentaoxahexadecan-16-ol 915-389-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC no. 203-962-1) 01/04/2022 16/05/2022 Details
Reaction mass of 2,5-bis(isocyanatomethyl)-bicyclo[2.2.1]heptane and 2,6-bis(isocyanatomethyl)-bicyclo[2.2.1]heptane 411-280-2 - Genetic toxicity in vivo 16/07/2012 30/08/2012 Details
Reaction mass of 2,6-Octadien-1-ol, 3,7-dimethyl-, (E) and 2,6-Octadien-1-ol, 3,7-dimethyl-, (Z)- 906-125-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
15/08/2011
15/08/2011
Details
Reaction mass of 2,7-Naphthalenedisulfonic acid, 5-amino-3-[[4-[2-[4-[(7-amino-1-hydroxy-3-sulfo-2-naphthalenyl)azo]-2-sulfophenyl]ethenyl]-3-sulfophenyl]azo]-4-hydroxy-, compd. with 2,2',2''-nitrilotris[ethanol] (1:5) and 3,3'-[ethylenebis[(3-sulpho-p-phenylene)azo]]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonic] acid, compound with 2,2',2''-nitrilotriethanol (1:6) and 3,3'-[vinylenebis[(3-sulpho-p-phenylene)azo]]bis[6-amino-4-hydroxynaphthalene-2-sulphonic] acid, compound with 2,2',2''-nitrilotriethanol (1:4) 916-899-6 - Sub-chronic toxicity (90-day): oral 10/08/2018 24/09/2018 Details
Reaction mass of 2-(1,1-dimethylpropyl)anthraquinone and 2-(1,2-dimethylpropyl)anthraquinone 915-623-1 -
Genetic toxicity in vivo
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
Reaction mass of 2-(1,1-dimethylpropyl)anthraquinone and 2-(1,2-dimethylpropyl)anthraquinone 915-623-1 - Reproductive toxicity (pre-natal developmental toxicity) 15/04/2014 30/05/2014 Details
Reaction mass of 2-(1,1-dimethylpropyl)anthraquinone and 2-(1,2-dimethylpropyl)anthraquinonedimethylpropyl)anthraquinone 915-623-1 -
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
Details
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) 10/08/2018 24/09/2018 Details
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) 27/05/2019 11/07/2019 Details
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity)
1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
27/01/2020 12/03/2020 Details
Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid 940-877-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/03/2019
29/03/2019
13/05/2019
13/05/2019
Details
Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol 941-357-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
08/02/2017
08/02/2017
27/03/2017
27/03/2017
Details
Reaction mass of 2-ethyl-2-(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3-diol 938-572-7 - Long-term toxicity to fish 22/09/2022 07/11/2022 Details
Reaction mass of 2-ethyl-2-(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3-diol 938-572-7 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/09/2018
06/09/2018
22/10/2018
22/10/2018
Details
Reaction mass of 2-ethylpropane-1,3-diol and 5-ethyl-1,3-dioxane-5-methanol and propylidynetrimethanol 904-153-2 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
12/09/2011
12/09/2011
Details
Reaction mass of 2-methylpent-2-ene and diisopropyl ether 906-484-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
29/07/2011
29/07/2011
29/07/2011
12/09/2011
12/09/2011
12/09/2011
Details
Reaction mass of 2-tert-butyl-4,6-dimethylphenol and 4-tert-butyl-2,5-dimethylphenol 911-254-5 - Reproductive toxicity (pre-natal developmental toxicity) 16/06/2011 01/08/2011 Details
Reaction mass of 3,5,6,6-tetramethyl-4-methyleneheptan-2-one and (E)-3,4,5,6,6-pentamethylhept-3-en-2-one 946-245-5 - Reproductive toxicity (pre-natal developmental toxicity) 06/06/2023 21/07/2023 Details
Reaction mass of 3-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde and 4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde 915-650-9 -
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with 3-CYCLOHEXENE-1-CARBOXALDEHYDE MULTICONSTITUENT (EC no. 253-617-4) (EC no. 257-943-8)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with 3-CYCLOHEXENE-1-CARBOXALDEHYDE MULTICONSTITUENT (EC no. 253-617-4) (EC no. 257-943-8)
04/09/2023
04/09/2023
19/10/2023
19/10/2023
Details
Reaction mass of 3-isopropyl-6-methylenecyclohexene and (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene and (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexene 939-009-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
Reaction mass of 3-isopropyl-6-methylenecyclohexene and (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene and (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexene 939-009-8 - Sub-chronic toxicity (90-day): oral 21/12/2021 04/02/2022 Details
Reaction mass of 3-isopropyl-6-methylenecyclohexene and (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene and (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexene 939-009-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/09/2017
01/09/2017
16/10/2017
16/10/2017
Details
Reaction mass of 4,4'-methylenediphenyl diisocyanate and Amines, soya alkyl 905-837-3 - Long-term toxicity to fish || Note: substance forms part of category; testing is also proposed with Reaction product of 4,4'-methylenediphenyl diisocyanate (MDI), Octylamine and Hexamethylenediamine (EC no. 923-615-4) 26/08/2021 11/10/2021 Details
Reaction mass of 4,4'-methylenediphenyl diisocyanate and o-(p-isocyanatobenzyl)phenyl isocyanate / methylene diphenyl diisocyanate 905-806-4 - Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 16/06/2022 01/08/2022 Details
Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane 915-748-1 -
Reproductive toxicity (pre-natal developmental toxicity) // Note: testing proposed with (CAS 211519-85-6)
Reproductive toxicity (two-generation reproductive toxicity) // Note: testing proposed with (CAS 211519-85-6)
17/06/2014
17/06/2014
01/08/2014
01/08/2014
Details
Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane 915-748-1 - Sub-chronic toxicity (90-day): oral || Note: testing proposed with polysulfides, bis[3-(triethyoxysilyl)propyl (CAS No 211519-85-6) 25/05/2020 09/07/2020 Details
Reaction mass of 4-tert-butylphenol and 1,3- phenylenedimethanamine and 2-({[3-(aminomethyl) benzyl]amino}methyl)-4-tert-butylphenol 939-071-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/07/2013
02/07/2013
16/08/2013
16/08/2013
Details
Reaction mass of 4-tert-butylphenyl diphenyl phosphate and bis(4-tert-butylphenyl) phenyl phosphate and triphenyl phosphate 700-990-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) 22/09/2022 07/11/2022 Details
Reaction mass of 6-Amino-5-(4-substituted-sulfophenylazo)-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt and 6-Amino-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-5-[sulfo- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt 445-040-3 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Details
Reaction mass of 6-Chloro-2-{4[ethyl(2-hydroxyethyl)amino]phenyl}-1-methylbenzo[cd]indolium hydroxide and 6-chloro-2-[4-[ethyl(2-hydroxyethyl)amino]phenyl]-1-methylbenz[cd]indolium acetate 946-378-9 - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 16/12/2020 01/02/2021 Details
Reaction mass of [[(2-hydroxyethyl)imino]bis(methylene)]bisphosphonic acid and Phosphonic acid, P-[(tetrahydro-2-hydroxy-2-oxido-4H-1,4,2-oxazaphosphorin-4-yl)methyl]- 911-811-2 -
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
17/04/2015
04/06/2015
04/06/2015
04/06/2015
Details
Reaction mass of [[(2-hydroxyethyl)imino]dimethylene]bisphosphonic acid, sodium salt and 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane, sodium salt 939-513-8 -
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
Sub-chronic toxicity (90-day): oral
Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Details
Reaction mass of Amides, rape-oil, N-(hydroxyethyl), ethoxylated and Glycerol, ethoxylated 932-164-2 -
Long-term toxicity to fish
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
12/09/2011
12/09/2011
Details
Reaction mass of Amines, coco alkyl and β-Alanine, N-(2-carboxyethyl)-, N-coco alkyl derivs. and β-Alanine, N-coco alkyl derivs. 915-790-0 - Sub-chronic toxicity (90-day): oral 12/12/2014 26/01/2015 Details
Reaction mass of Ammonium bisethanedioato bisaquo niobate(V) (anhydrous form) and Ammonium hydrogen ethanedioate ethanedioic acid (anhydrous form 939-559-9 - Reproductive toxicity (pre-natal developmental toxicity) 01/09/2017 16/10/2017 Details
Reaction mass of Benzeneacetic acid, alpha-oxo-, 1,1'-(oxydi-2,1-ethanediyl) ester and Benzeneacetic acid, alpha-oxo-, 2-(2-hydroxyethoxy)ethyl ester 442-300-8 - Sub-chronic toxicity (90-day): oral 04/10/2013 18/11/2013 Details
Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate 701-008-3 - Reproductive toxicity (extended one-generation reproductive toxicity study) 27/05/2019 11/07/2019 Details
Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate 905-983-8 - Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
Reaction mass of Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and Methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate 915-687-0 - Genetic toxicity in vivo 15/09/2011 31/10/2011 Details
Reaction mass of bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate and 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane 406-750-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
04/06/2012
04/06/2012
19/07/2012
19/07/2012
Details
reaction mass of bis(2,3-epoxypropyl) terephthalate and tris(oxiranylmethyl) benzene-1,2,4-tricarboxylate 940-592-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposal is based on concern identified by the registrant
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
16/02/2015
02/04/2015
02/04/2015
02/04/2015
Details
Reaction mass of bisisopropyl peroxydicarbonate and bis-sec-butyl peroxydicarbonate and isopropyl-sec-butylperoxydicarbonate 931-536-1 - Genetic toxicity in vivo || Note: testing proposed with bisisopropyl peroxydicarbonate EC 203-317-4, CAS 105-64-6 (is a constituent of the multi-constituent registered substance) || Note: Testing proposal is based on concern identified by the registrant 24/08/2020 08/10/2020 Details
Reaction mass of C18 (unsatd.) fatty acid amides/esters of diethanolamine, C16-18 (even-numbered) fatty amine (..) 943-172-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/05/2016
17/05/2016
17/05/2016
01/07/2016
01/07/2016
01/07/2016
Details
Reaction Mass of Cis-4-(isopropyl) cyclohexanemethanol and Trans-4-(isopropyl) cyclohexanemethanol 939-719-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
Details
Reaction mass of cobalt and copper and iron 912-664-7 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Details
Reaction mass of cobalt sulphide and nickel sulphide and trinickel disulphide 910-663-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Details
Reaction mass of dibutyl adipate and dibutyl glutarate 936-196-8 -
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Reaction mass of dimethyl adipate, dimethyl glutarate and dimethyl succinate (EC 906-170-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction mass of dimethyl adipate, dimethyl glutarate and dimethyl succinate (EC 906-170-0)
16/12/2020
16/12/2020
01/02/2021
01/02/2021
Details
Reaction mass of diisobutyl adipate and diisobutyl glutarate and diisobutyl succinate 907-870-9 -
Reproductive toxicity (extended one-generation reproductive toxicity study) ||Note: testing proposed with Reaction mass of dimethyl adipate and dimethyl glutarate and dimethyl succinate (EC 906-170-0 )
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Reaction mass of dimethyl adipate and dimethyl glutarate and dimethyl succinate (EC 906-170-0 )
22/09/2022
22/09/2022
07/11/2022
07/11/2022
Details
Reaction mass of diisobutyl hydrogen phosphate and isobutyl dihydrogen phosphate 911-351-2 - Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate 950-225-1 -
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8)
17/12/2019
17/12/2019
31/01/2020
31/01/2020
Details
Reaction mass of dipotassium 3,3'-sulphonylbis(benzenesulphonate) and potassium 3-(phenylsulphonyl)benzenesulphonate 915-932-1 - Genetic toxicity in vivo 26/08/2021 11/10/2021 Details
Reaction mass of disodium (sulphonatothio)acetate and sodium chloride 947-115-0 - Genetic toxicity in vivo 17/06/2020 03/08/2020 Details
Reaction mass of Disodium dihydroxy[3-(hydroxy-kO)-4-{[5-(hydroxy-kO)-3-methyl-1-phenyl-1Hpyrazol-4-yl]diazenyl-kN1}naphthalene-1-sulfonato(3-)]chromate(2-) and sodium [4-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-3-hydroxynaphthalene-1-sulphonato(3-)]hydroxychromate(1-) 944-272-7 - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
Reaction mass of disodium hydroxysulfinatoacetate and disodium hydroxysulfonatoacetate - -
Reproductive toxicity (developmental toxicity)
Sub-chronic toxicity study (90-day): oral
13/12/2010
13/12/2010
27/01/2011
27/01/2011
Details
Reaction mass of Ethanaminium, 2-hydroxy-N,N-dimethyl-N-[2-[(1-oxooctadecyl)oxy]ethyl]-, chloride and Ethanaminium, N,N-dimethyl-2-[(1-oxohexadecyl)oxy]-N-[2-[(1-oxooctadecyl)oxy]ethyl]-, chloride 951-974-7 - Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Ethanaminium, 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-, esters with C16-18 and C18-unsatd. fatty acids, chlorides (EC 620-174-7) 23/11/2020 07/01/2021 Details
Reaction mass of ethoxylated (= 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate 939-702-5 - Long-term toxicity to fish 25/11/2019 09/01/2020 Details
Reaction mass of ethoxylated (≥ 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate 939-702-5 -
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Ethoxylated bisphenol A diacrylate
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Ethoxylated bisphenol A diacrylate
12/12/2014
12/12/2014
26/01/2015
26/01/2015
Details
Reaction mass of hydrogenated and dehydrogenated rosin 911-238-8 -
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
19/07/2013
19/07/2013
02/09/2013
02/09/2013
Details
Reaction mass of methyl dihydrogen phosphate and orthophosphoric acid and dimethyl hydrogen phosphate 908-996-7 -
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1).
Sub-chronic toxicity (90-day): oral || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1).
20/05/2015
20/05/2015
06/07/2015
06/07/2015
Details
Reaction mass of N,N,N',N'-tetrabutylmethylenediamine and dibutylamine 948-040-6 - Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: Testing proposal is based on concern identified by the registrant. 24/01/2019 11/03/2019 Details
Reaction mass of N-[2-(2-oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid 934-058-1 -
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
Details
Reaction mass of N-butylphthalimide and N-sec-butylphthalimide and N-propylphthalimide 943-947-3 - Genetic toxicity in vivo 19/10/2020 03/12/2020 Details
Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- 907-495-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit
Sub-chronic toxicity (90 day): inhalation
27/05/2019
27/05/2019
27/05/2019
11/07/2019
11/07/2019
11/07/2019
Details
Reaction mass of p-mentha-1,4-diene and p-mentha-1,3-diene and dipentene and p-mentha-1(7),2-diene and p-mentha-1,4(8)-diene 931-893-3 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
31/10/2011
31/10/2011
Details
Reaction mass of Poly(oxy-1,2-ethanediyl), ?-[2-[(2-hydroxyethyl)amino]-2-oxoethyl]-?-hydroxy-, mono-C13-15-alkyl ethers (odd numbered, branched and linear)-alkylethers, Acetamide, 2-(C13-15 (odd numbered, branched and linear)-alkyloxy)-N-(2-hydroxyethyl)- and Alcohols, C13-15-branched and linear - - Reproductive toxicity (pre-natal developmental toxicity) 16/08/2011 30/09/2011 Details
Reaction mass of potassium ethyl octylphosphonate and diethyl octylphosphonate 939-595-5 - Reproductive toxicity (pre-natal developmental toxicity) 17/04/2015 04/06/2015 Details
Reaction mass of propylidynetrimethanol and 2-ethylpropane-1,3-diol and 5-ethyl-1,3-dioxane-5-methanol 904-153-2 - Reproductive toxicity (extended one-generation reproductive toxicity study) 18/02/2021 05/04/2021 Details
Reaction mass of resin acids and rosin acids, hydrogenated, potassium salts and potassium [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylate 915-657-7 -
Pre-natal developmental toxicity, //Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
Two-generation reproductive toxicity, //Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
19/07/2013
19/07/2013
02/09/2013
02/09/2013
Details
Reaction mass of resin acids and rosin acids, hydrogenated, sodium salts and sodium [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7- -isopropyl-1,4a-dimethylphenanthren-1-carboxylate 915-568-3 -
Pre-natal developmental toxicity, //Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
Two-generation reproductive toxicity, //Note: Testing proposed with Rosin (CAS RN 8050-09-7) and Reaction mass of hydrogenated and dehydrogenated rosin (CAS RN 911-238-8)
19/07/2013
19/07/2013
02/09/2013
02/08/2013
Details
Reaction mass of Rosin, hydrogenated and [1R-(1a,4ß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid 911-238-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/03/2011
15/03/2011
29/04/2011
29/04/2011
Details
Reaction mass of sodium 1-methoxy-1-oxohexadecane-2-sulphonate and sodium methyl 2-sulphooctadecanoate 911-616-2 - Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020 Details
Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid 939-201-1 - Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015 Details
Reaction mass of Sodiumbis[1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and Sodium [1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)][1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and Sodiumbis[1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) 915-756-5 - Genetic toxicity in vivo 21/12/2021 04/02/2022 Details
Reaction mass of trientine and trientine, mono- and di-propoxylated 942-835-1 - Genetic toxicity in vivo||Note: testing proposed with [Amines, polyethylenepoly-, triethylenetetramine fraction] (EC no. 292-588-2) 03/10/2023 17/11/2023 Details
Reaction mass of trisodium [μ-[4-[[3,3'-dihydroxy-4'-[(2-hydroxy-6-sulpho-1-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]-3-hydroxynaphthalene-2,7-disulphonato(7-)]]dicuprate(3-) and triammonium [μ-[4-[[3,3'-dihydroxy-4'-[(2-hydroxy-6-sulpho-1-naphthyl)azo][1,1'-biphenyl]-4-yl]azo]-3-hydroxynaphthalene-2,7-disulphonato(7-)]]dicuprate(3-) 945-577-8 - Sub-chronic toxicity (90-day): oral 01/07/2021 16/08/2021 Details
reaction mass of: 2-(2-((oxo(phenyl)acetyl)oxy)ethoxy)ethyl oxo(phenyl)acetate (2-(2-hydroxyethoxy)ethyl) oxo(phenyl)acetate 442-300-8 - Reproductive toxicity (pre-natal developmental toxicity) 15/01/2013 01/03/2013 Details
Reaction product Formaldehyde, amine and phenol 476-290-1 - Genetic toxicity in vivo 15/08/2013 30/09/2013 Details
Reaction product of 2,4-Dinitrotoluene and 2,6-Dinitrotoluene and hydrogen 939-489-9 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2021
18/02/2021
05/04/2021
05/04/2021
Details
Reaction product of 2,4-Dinitrotoluene and 2,6-Dinitrotoluene and hydrogen 939-489-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
Details
Reaction product of 4,4'-methylenediphenyl diisocyanate (MDI) (101-68-8), Octylamine (111-86-4) and Cyclohexylamine (108-91-8) 926-119-6 - Long-term toxicity to fish || Note: testing proposed with Reaction mass of 4,4'-methylenediphenyl diisocyanate and Amines, soya alkyl (EC 905-837-3) and Reaction product of 4,4'-methylenediphenyl diisocyanate (MDI) (CAS: 101-68-8), Octylamine (111-86-4) and Hexamethylenediamine (124-09-4) (EC no 924-670-7) 30/09/2021 15/11/2021 Details
Reaction product of 4,4'-methylenediphenyl diisocyanate, Octylamine and Hexamethylenediamine 924-670-7 - Long-term toxicity to fish || Note: testing proposed with Reaction mass of 4,4'-methylenediphenyl diisocyanate and Amines, soya alkyl (EC no. 905-837-3) 16/06/2022 01/08/2022 Details
Reaction product of Crude sludge and Calcium oxide. Crude sludge is the mixture of by-products of petroleum hydrocarbons refining (especially Total petroleum hydrocarbons, Polycyclic aromatic hydrocarbons, acid-refined heavy petroleum distillates). The Crude sludge is neutralised by calcium oxide in the ratio 80:20. The maturing process proceeds under ambient conditions and takes for at least 3 days. Subsequently, the reaction product is processed mechanically 930-592-4 - Reproductive toxicity (pre-natal developmental toxicity) 20/09/2013 04/11/2013 Details
Reaction product of Distillates (petroleum), acid-treated heavy naphthenic and calcium oxide - - Reproductive toxicity (pre-natal developmental toxicity) 16/08/2011 30/09/2011 Details
Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda 939-368-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
17/06/2014
17/06/2014
01/08/2014
01/08/2014
Details
Reaction product of: polyethylene-polyamine-(C16-C18)-alkylamides with monothio-(C2)-alkyl phosphonates 417-450-2 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/06/2023
30/06/2023
14/08/2023
14/08/2023
Details
reaction products of 1,4-butanediol with 1,3-chloro-2,3-epoxypropane, esters with prop-2-enoic acid 701-230-0 - Long-term toxicity to fish 10/05/2022 27/06/2022 Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C11-17 and C17 unsatd. alkyl) derivs. and sodium hydroxide and 2-propenoic acid 946-533-0 - Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0) 23/04/2018 07/06/2018 Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C11-17 and C17 unsatd. alkyl) derivs. and sodium hydroxide and 2-propenoic acid 946-533-0 - Sub-chronic toxicity (90-day): oral || Note: testing proposed with β-Alanine, N-(2-aminoethyl)-N-(2-hydroxyethyl)-, N-coco acyl derivs., monosodium salts (EC 298-632-7) 16/12/2020 01/02/2021 Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C11-C13 odd-numbered alkyl) derivs. and sodium hydroxide and chloroacetic acid 938-645-3 -
Long-term toxicity to fish Note: testing proposed with [Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C11 alkyl) derivs. and sodium hydroxide and chloroacetic acid] (EC 271-794-6)
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid] (EC 931-291-0)
Sub-chronic toxicity (90-day): oral Note: testing proposed with [Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid] (EC 931-291-0)
16/03/2015
16/03/2015
16/03/2015
30/04/2015
30/04/2015
30/04/2015
Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid 931-291-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid - -
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
16/08/2011
16/08/2011
30/09/2011
30/09/2011
30/09/2011
30/09/2011
Details
Reaction products of 2-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-hydroxy phenol with ((C10-16, rich in C12-13 alkyloxy)methyl)oxyrane 410-560-1 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/01/2012
16/01/2012
01/03/2012
01/03/2012
Details
Reaction products of 5,5-dimethylhydantoin and ethylene oxide 701-388-0 - Reproductive toxicity (pre-natal developmental toxicity) 25/11/2021 10/01/2022 Details
Reaction products of [3-(2,3-epoxypropoxy)propyl]trimethoxysilane and triacetoxyvinylsilane 701-409-3 - Genetic toxicity in vivo 25/01/2022 11/03/2022 Details
Reaction products of adipic acid and 2,3-epoxypropyl C10-(branched) alkanoate 825-846-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2022
16/06/2022
01/08/2022
01/08/2022
Details
Reaction Products of alcohols, C14-18, C18 unsat., esterified with phosphorus pentoxide and salted with amines, C12-14,-tert-alkyl 939-591-3 - Reproductive toxicity (pre-natal developmental toxicity) 15/04/2014 30/05/2014 Details
Reaction products of amines, polyethylenepoly-, tetraethylenepentamine fraction and copper sulphate (1:1) 701-400-4 - Genetic toxicity in vivo 25/11/2021 10/01/2022 Details
Reaction products of amines, polyethylenepoly-, triethylenetetramine fraction and copper sulphate (1:1) 701-399-0 - "Genetic toxicity in vivo || Note: testing proposed with Reaction products of amines, polyethylenepoly-, tetraethylenepentamine fraction and copper sulphate (1:1) (EC 701-400-4)" 25/11/2021 10/01/2022 Details
Reaction products of anilinohydroxypolycyclicsulphonic acid coupled twice with diazotised aminonitrophenol, complexes with [3-hydroxy-4-[(2-hydroxy-1-polycyclic)azo]-7-nitropolycyclic-1-sulphonato(3-)]chromium, sodium salts - - Genetic toxicity in vivo 18/03/2021 03/05/2021 Details
Reaction products of boric acid and calcium dihydroxide and lithium hydroxide 701-453-3 - Genetic toxicity in vivo||Note: testing proposed with diboron calcium tetraoxide (EC no. 237-224-5) 22/09/2022 07/11/2022 Details
Reaction products of C18 (unsaturated) fatty acids and dimethyl sulfate and triethanolamine 931-216-1 - Long-term toxicity to fish || Note: testing proposed with Fatty acids, C16-18 (even numbered) and C18 unsatd., reaction products with diethylene triamine, di-Me sulfate quaternized (EC 937-237-2) 22/04/2021 07/06/2021 Details
Reaction products of di-, tri- and tetra-propoxylated propane-1,2-diol with ammonia 618-561-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018 Details
Reaction products of diazotised 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid, coupled with 1,3-diaminobenzene and diazotised sodium 4-aminobenzenesulfonate, metallized with Basic Chromium (III) Sulphate, sodium salts 947-395-4 - Genetic toxicity in vivo 18/03/2021 03/05/2021 Details
Reaction products of diazotised 4,4-diaminodiphenylamine-2-sulfonic acid, subsequently coupled with 6-amino-4-hydroxynaphthalene-2-sulfonic acid, further diazotised and coupled with metaphenylendiamine, sodium salts 939-382-7 - Genetic toxicity in vivo 25/11/2021 10/01/2022 Details
Reaction products of diazotised Sodium Picramate coupled with Resorcinol, subsequently coupled with diazotised 4'-Amino-4-Nitrodiphenylamin-2-Sulfonic Acid, at the end metallized with Iron (II) sulphate heptahydrate, sodium salts 946-788-8 - Genetic toxicity in vivo 18/03/2021 03/05/2021 Details
Reaction products of diphenylamine with nonene, branched 701-385-4 - Reproductive toxicity (extended one-generation reproductive toxicity study) 01/04/2022 16/05/2022 Details
Reaction products of Isophorone diamine, Butyl  glycidyl ether, and Bisphenol A diglicydyl ether - -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
22/06/2017
22/06/2017
07/08/2017
07/08/2017
Details
Reaction products of monoethanolamine and boric acid (1:1) 701-025-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
Reaction products of monoethanolamine and boric acid (1:3) 701-024-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
Reaction products of n-octanol and acrylic acid, first distillation pitch 938-925-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/03/2021
18/03/2021
03/05/2021
03/05/2021
Details
Reaction products of n-octanol and acrylic acid, first distillation pitch 938-925-5 - Long-term toxicity to fish 15/01/2024 29/02/2024 Details
Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) 701-083-2 -
"Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Details
Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide 701-196-7 -
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Details
Reaction products of polyaminoalkane and substituted octadecanoic acid 434-430-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2016
16/12/2016
30/01/2017
30/01/2016
Details
Reaction products of tetrazotized 5-amino-2-[(E)-2-(4-amino-2-sulfophenyl)ethenyl]benzenesulfonic acid with 6-amino-4-hydroxynaphthalene-2-sulfonic acid and 4-amino-5-hydroxynaphthalene-2,7-disulfonic acid in 2-[bis(2-hydroxyethyl)amino]ethanol 916-899-6 - Genetic toxicity in vivo 23/11/2020 07/01/2021 Details
Reaction products of tetrazotized 5-amino-2-[(E)-2-(4-amino-2-sulfophenyl)ethenyl]benzenesulfonic acid with 6-amino-4-hydroxynaphthalene-2-sulfonic acid and 4-amino-5-hydroxynaphthalene-2,7-disulfonic acid in 2-[bis(2-hydroxyethyl)amino]ethanol 916-899-6 - Long-term toxicity to fish 25/11/2021 10/01/2022 Details
Reaction products of tetrazotized 5-amino-2-[(E)-2-(4-amino-2-sulfophenyl)ethenyl]benzenesulfonic acid with 6-amino-4-hydroxynaphthalene-2-sulfonic acid and 4-amino-5-hydroxynaphthalene-2,7-disulfonic acid in 2-[bis(2-hydroxyethyl)amino]ethanol 916-899-6 - Genetic toxicity in vivo 16/12/2020 01/02/2021 Details
Reaction products of tryglycerides, C8-C18 (even numbered) and C18-unsaturated, glycerine and ethylene oxide 939-459-5 - Sub-chronic toxicity (90-day): oral 30/11/2015 14/01/2016 Details
Rectified Hydrocarbons by-products from synthetic process of Turpentine and acid, alcohols fraction 949-141-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
08/03/2021
08/03/2021
Details
Saccharomyces cerevisiae cell wall, extracted 949-711-6 -
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Saccharomyces cerevisiae, lysate (EC 305-230-8)
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Saccharomyces cerevisiae, lysate (EC 305-230-8)
25/11/2021
25/11/2021
10/01/2022
10/01/2022
Details
Shale oils, heavy 930-690-7 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
17/11/2011
14/03/2016
14/03/2016
02/01/2012
28/04/2016
28/04/2016
Details
Shale oils, light 923-592-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Shale oils, heavy fraction (Registration No 01-2119756217-35-0000)||” Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with Shale oils, heavy fraction (Registration No 01-2119756217-35-0000)||” 14/03/2016 28/04/2016 Details
Shale oils, light 923-592-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
17/11/2011
17/11/2011
17/11/2011
02/01/2012
02/01/2012
02/01/2012
Details
Slags, steelmaking, elec. furnace (stainless/high alloy steel production) 932-476-9 - Sub-chronic toxicity (90 day): inhalation 06/03/2012 20/04/2012 Details
Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) 947-369-2 -
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Details
Sophorolipids: fermentation products of glucose and fatty acids, C18 (unsaturated), glycerol esters with yeast Candida Bombicola, partially hydrolysed 941-809-7 - Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. 24/07/2019 09/09/2019 Details
Soybean oil, oligomerized 701-252-0 - Reproductive toxicity (pre-natal developmental toxicity) 06/09/2018 22/10/2018 Details
SUMILIZER GP 442-450-4 - Long-term toxicity to fish 25/11/2021 10/01/2022 Details