Korábbi/eredmények
Korábbi/eredmények
Korábbi/eredmények
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
3-trimethoxysilylpropane-1-thiol | 224-588-5 | 4420-74-0 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1)
|| Note: Testing proposal is based on concern identified by the registrant. |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
4-morpholinecarbaldehyde | 224-518-3 | 4394-85-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
4-morpholinecarbaldehyde | 224-518-3 | 4394-85-8 | Sub-chronic toxicity (90-day): oral | 04/04/2014 | 19/05/2014 | Details | |
2,2,4,4,6,8,8-heptamethylnonane | 224-506-8 | 4390-04-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) | 02/11/2018 | 17/12/2018 | Details | |
Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane | 224-506-8 | 4390-04-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) | 224-235-5 | 4259-15-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) | 224-235-5 | 4259-15-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Di-tert-butyl trisulphide | 224-226-6 | 4253-90-1 | Long-term toxicity to fish | 30/06/2023 | 14/08/2023 | Details | |
Di-tert-butyl trisulphide | 224-226-6 | 4253-90-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/03/2023 01/03/2023 01/03/2023 |
17/04/2023 17/04/2023 17/04/2023 |
Details | |
methylsilanetriyl triacetate | 224-221-9 | 4253-34-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [Trimethoxy(methyl)silane] (EC 214-685-0) | 16/03/2015 | 30/04/2015 | Details | |
methylsilanetriyl triacetate | 224-221-9 | 4253-34-3 | Sub-chronic toxicity (90-day): oral||Note: testing proposed with [triethoxy(methyl)silane] (CAS no. 2031-67-6) | 03/10/2023 | 17/11/2023 | Details | |
3,3'-oxybis(ethyleneoxy)bis(propylamine) | 224-207-2 | 4246-51-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2021 18/02/2021 |
05/04/2021 05/04/2021 |
Details | |
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate | 224-116-8 | 4203-89-8 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
2,2-dimethylpropane-1,3-diyl dibenzoate | 224-081-9 | 4196-89-8 | Reproductive toxicity (pre-natal developmental toxicity) | 29/02/2016 | 14/04/2016 | Details | |
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate | 223-989-2 | 4156-21-2 | Sub-chronic toxicity (90-day): oral | 29/04/2014 | 13/06/2014 | Details | |
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate | 223-989-2 | 4156-21-2 | Reproductive toxicity (pre-natal developmental toxicity) | 03/04/2023 | 22/05/2023 | Details | |
Tris(p-isocyanatophenyl) thiophosphate | 223-981-9 | 4151-51-3 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide | 223-829-1 | 4090-51-1 | Sub-chronic toxicity (90-day): oral | 16/06/2022 | 01/08/2022 | Details | |
3,6,9,12-tetraazatetradecamethylenediamine | 223-775-9 | 4067-16-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
28/02/2011 28/02/2011 |
14/04/2011 14/04/2011 |
Details | |
3,6,9,12-tetraazatetradecamethylenediamine | 223-775-9 | 4067-16-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with structural analogues TETA (CAS 90640-67-8) and HEPA (CAS 68121-73-7). Reproductive toxicity (pre-natal developmental toxicity) |
22/11/2017 22/11/2017 |
08/01/2018 08/01/2018 |
Details | |
2,3-epoxypropyl isopropyl ether | 223-672-9 | 4016-14-2 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
Nonane-1,9-diol | 223-517-5 | 3937-56-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral |
16/12/2020 16/12/2020 |
01/02/2021 01/02/2021 |
Details | |
Nonane-1,9-diol | 223-517-5 | 3937-56-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral |
05/07/2018 05/07/2018 |
20/08/2018 20/08/2018 |
Details | |
Sodium chloroacetate | 223-498-3 | 3926-62-3 | Reproductive toxicity (pre-natal developmental toxicity) | 14/10/2011 | 28/11/2011 | Details | |
Sodium chloroacetate | 223-498-3 | 3926-62-3 | Reproductive toxicity (two-generation reproductive toxicity) | 16/06/2011 | 01/08/2011 | Details | |
Bumetrizole | 223-445-4 | 3896-11-5 | Bioaccumulation aquatic / sediment | 18/06/2018 | 02/08/2018 | Details | |
bis(3,5,5-trimethylhexanoyl) peroxide | 223-356-0 | 3851-87-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
Octa-1,7-diene | 223-054-9 | 3710-30-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Diundecyl phthalate | 222-884-9 | 3648-20-2 | Reproductive toxicity (pre-natal developmental toxicity) | 25/11/2021 | 10/01/2022 | Details | |
Dioctyltin dilaurate | 222-883-3 | 3648-18-8 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
1,3-bis(isocyanatomethyl)benzene | 222-852-4 | 3634-83-1 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
N-butylbenzenesulphonamide | 222-823-6 | 3622-84-2 | Reproductive toxicity (pre-natal developmental toxicity) | 14/02/2011 | 31/03/2011 | Details | |
N-butylbenzenesulphonamide | 222-823-6 | 3622-84-2 | Reproductive toxicity (pre-natal developmental toxicity) | 29/02/2016 | 14/04/2016 | Details | |
1-butylpyrrolidin-2-one | 222-437-8 | 3470-98-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/01/2022 | 11/03/2022 | Details | |
1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
tert-butyl α,α-dimethylbenzyl peroxide | 222-389-8 | 3457-61-2 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 16/03/2015 | 30/04/2015 | Details | |
tert-butyl α,α-dimethylbenzyl peroxide | 222-389-8 | 3457-61-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
Icos-1-ene | 222-374-6 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
1-(2-hydroxyethyl)pyrrolidin-2-one | 222-359-4 | 3445-11-2 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |
1-(2-hydroxyethyl)pyrrolidin-2-one | 222-359-4 | 3445-11-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/12/2020 16/12/2020 16/12/2020 |
01/02/2021 01/02/2021 01/02/2021 |
Details | |
Bisisobutyryl peroxide | 222-340-0 | 3437-84-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 19/05/2014 |
Details | |
tert-pentyl hydroperoxide | 222-321-7 | 3425-61-4 | Genetic toxicity in vivo | 21/03/2014 | 05/05/2014 | Details | |
tert-pentyl hydroperoxide | 222-321-7 | 3425-61-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
07/10/2016 07/10/2016 |
21/11/2016 21/11/2016 |
Details | |
sodium O,O-diethyl dithiophosphate || Note: testing proposed with sodium O,O-diisobutyl dithiophosphate (EC 258-508-5) | 222-079-2 | 3338-24-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
3,5,5-trimethylhexanoic acid | 221-975-0 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 |
Details | |
Propylidynetrimethyl trimethacrylate | 221-950-4 | 3290-92-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/04/2019 | 10/06/2019 | Details | |
Propylidynetrimethyl trimethacrylate | 221-950-4 | 3290-92-4 | Reproductive toxicity (pre-natal developmental toxicity) | 31/05/2016 | 15/07/2016 | Details | |
1,1,3,3-tetramethyldisiloxane | 221-906-4 | 3277-26-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
29/04/2016 29/04/2016 |
13/06/2016 13/06/2016 |
Details | |
Furan-2,5-dicarboxylic acid | 221-800-8 | 3238-40-2 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol | 221-573-5 | 3147-75-9 | Bioaccumulation aquatic / sediment | 15/07/2014 | 29/08/2014 | Details | |
2-methoxyethyl acrylate | 221-499-3 | 3121-61-7 | Genetic toxicity in vivo | 21/03/2014 | 05/05/2014 | Details | |
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether | 221-453-2 | 3101-60-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2014 17/06/2014 17/06/2014 17/06/2014 |
01/08/2014 01/08/2014 01/08/2014 01/08/2014 |
Details | |
Trimethoxyoctylsilane | 221-338-7 | 3069-40-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study || Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1) |
27/09/2017 27/09/2017 |
13/11/2017 13/11/2017 |
Details | |
trimethoxyoctylsilane | 221-338-7 | 3069-40-7 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (CAS 35435-21-3) | 07/08/2015 | 22/09/2015 | Details | |
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine | 221-336-6 | 3069-29-2 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Tetra(isobutyl)thioperoxydicarbamic acid | 221-312-5 | 3064-73-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/06/2018 18/06/2018 |
02/08/2018 02/08/2018 |
Details | |
3-ethyloxetane-3-methanol | 221-254-0 | 3047-32-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2014 31/01/2014 |
17/03/2014 17/03/2014 |
Details | |
3-ethyloxetane-3-methanol | 221-254-0 | 3047-32-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
N,N,N',N'-tetramethyl-2,2'-oxybis(ethylamine) | 221-220-5 | 3033-62-3 |
7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity |
08/03/2024 08/03/2024 |
22/04/2024 22/04/2024 |
Details | |
hex-3-yne-2,5-diol | 221-209-5 | 3031-66-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
bis(2-dimethylaminoethyl)(methyl)amine | 221-201-1 | 3030-47-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
Cyclohexylidenebis[tert-butyl] peroxide | 221-111-2 | 3006-86-8 | Sub-chronic toxicity (90-day): oral | 21/03/2014 | 05/05/2014 | Details | |
tert-butyl 2-ethylperoxyhexanoate | 221-110-7 | 3006-82-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
3,9-dimethyl-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane 3,9-dioxide | 221-088-9 | 3001-98-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/12/2020 16/12/2020 |
01/02/2021 01/02/2021 |
Details | |
2,2'-azobis[2-methylpropionamidine] dihydrochloride | 221-070-0 | 2997-92-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
05/07/2018 05/07/2018 |
20/08/2018 20/08/2018 |
Details | |
Trimethoxyphenylsilane | 221-066-9 | 2996-92-1 | Reproductive toxicity (pre-natal developmental toxicity) | 03/03/2014 | 17/04/2014 | Details | |
Triethoxyoctylsilane | 220-941-2 | 2943-75-1 | Long-term toxicity to fish || Note: testing proposed with Triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1) | 17/04/2015 | 04/06/2015 | Details | |
Triethoxyoctylsilane | 220-941-2 | 2943-75-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/09/2017 27/09/2017 27/09/2017 |
13/11/2017 13/11/2017 13/11/2017 |
Details | |
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane | 220-780-8 | 2897-60-1 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 16/12/2016 | 30/01/2017 | Details | |
2,2,6,6-tetramethyl-4-oxopiperidinooxy | 220-778-7 | 2896-70-0 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2) Sub-chronic toxicity (90-day): oral || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2) |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
2,2,6,6-tetramethyl-4-oxopiperidinooxy | 220-778-7 | 2896-70-0 | Sub-chronic toxicity (90-day): oral | 03/04/2023 | 22/05/2023 | Details | |
N-(1,1-dimethyl-3-oxobutyl)acrylamide | 220-713-2 | 2873-97-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide – nano form | 220-509-3 | 2786-76-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with [3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide] (EC no. 229-440-3) | 03/10/2023 | 17/11/2023 | Details | |
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate | 220-482-8 | 2781-11-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Allyl 3-cyclohexylpropionate | 220-292-5 | 2705-87-5 | Reproductive toxicity (pre-natal developmental toxicity) | 26/10/2022 | 12/12/2022 | Details | |
N-ethyl-2-pyrrolidone (NEP) | 220-250-6 | 2687-91-4 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day) via the inhalatory route |
26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 |
Details | |
1,1,3,3-tetramethyl-1,3-divinyldisiloxane | 220-099-6 | 2627-95-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
[3-(2,3-epoxypropoxy)propyl]triethoxysilane | 220-011-6 | 2602-34-8 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
Dimethyl 2,2'-azobis(2-methylpropionate) | 219-976-6 | 2589-57-3 | Genetic toxicity in vivo | 17/06/2020 | 03/08/2020 | Details | |
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane | 219-863-1 | 2554-06-5 |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation |
03/03/2014 03/03/2014 03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 17/04/2014 17/04/2014 |
Details | |
4-phenylbutan-2-one | 219-847-4 | 2550-26-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons | 22/11/2017 | 08/01/2018 | Details | |
Triethoxypropylsilane | 219-842-7 | 2550-02-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
2,2'-methylenediphenyl diisocyanate | 219-799-4 | 2536-05-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
3-chloropropyltrimethoxysilane | 219-787-9 | 2530-87-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 |
Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) |
01/09/2017 01/09/2017 |
16/10/2017 16/10/2017 |
Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): inhalation |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | 2530-83-8 |
6.1.2 Long-term toxicity to fish 7.8.1 Toxicity to reproduction |
08/03/2024 08/03/2024 |
22/04/2024 22/04/2024 |
Details | |
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | 2530-83-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | 2530-83-8 | Genetic toxicity in vivo | 01/08/2012 | 17/09/2012 | Details | |
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | 2530-83-8 | Genetic toxicity in vivo | 16/02/2015 | 02/04/2015 | Details | |
3-(trimethoxysilyl)propiononitrile | 219-764-3 | 2526-62-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/03/2014 21/03/2014 |
05/05/2014 05/05/2014 |
Details | |
Strontium bis(2-ethylhexanoate) | 219-536-3 | 2457-02-5 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [strontium oxide] (EC 215-219-9) | 23/11/2020 | 07/01/2021 | Details | |
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) | 219-514-3 | 2451-62-9 | Reproductive toxicity (two-generation reproductive toxicity) | 19/11/2010 | 03/01/2011 | Details | |
2-(2H-benzotriazol-2-yl)-p-cresol | 219-470-5 | 2440-22-4 | Bioaccumulation aquatic / sediment | 18/06/2018 | 02/08/2018 | Details | |
11-aminoundecanoic acid | 219-417-6 | 2432-99-7 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
11-aminoundecanoic acid | 219-417-6 | 2432-99-7 | Reproductive toxicity (developmental toxicity) | 08/04/2010 | 24/05/2010 | Details | |
1,4-bis(2,3-epoxypropoxy)butane | 219-371-7 | 2425-79-8 | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) | 23/03/2020 | 07/05/2020 | Details | |
1,4-bis(2,3-epoxypropoxy)butane | 219-371-7 | 2425-79-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): most appropriate route |
14/02/2011 14/02/2011 14/02/2011 |
31/03/2011 31/03/2011 31/03/2011 |
Details | |
2-Hexyldecan-1-ol | 219-370-1 | 2425-77-6 | Reproductive toxicity (two-generation reproductive toxicity) | 05/04/2011 | 20/05/2011 | Details | |
Benzophenone-3,3':4,4'-tetracarboxylic dianhydride | 219-348-1 | 2421-28-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
2,4,6,8-tetramethylcyclotetrasiloxane | 219-137-4 | 2370-88-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
2,4,6,8-tetramethylcyclotetrasiloxane | 219-137-4 | 2370-88-9 |
Sub-chronic toxicity (90-day): oral - |
22/11/2017 22/11/2017 |
08/01/2018 08/01/2017 |
Details | |
2,4,6,8-tetramethylcyclotetrasiloxane | 219-137-4 | 2370-88-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
Octyl octanoate | 218-980-5 | 2306-88-9 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
03/04/2023 03/04/2023 03/04/2023 |
22/05/2023 22/05/2023 22/05/2023 |
Details | |
N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide | 218-915-0 | 2280-49-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl | 218-760-9 | 2226-96-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl | 218-760-9 | 2226-96-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 |
Details | |
butan-2-one O,O',O''-(vinylsilylidyne)trioxime | 218-747-8 | 2224-33-1 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9). |
25/06/2015 | 10/08/2015 | Details | |
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) | 218-679-9 | 2215-35-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category. Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) | 218-679-9 | 2215-35-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with, zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 218-664-7 | 2212-81-9 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant |
20/10/2016 20/10/2016 |
05/12/2016 05/12/2016 |
Details | |
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 218-664-7 | 2212-81-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide CAS: 25155-25-3)” | 25/05/2020 | 09/07/2020 | Details | |
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 218-664-7 | 2212-81-9 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2012 16/05/2012 16/05/2012 |
02/07/2012 02/07/2012 02/07/2012 |
Details | |
2,3-epoxypropyl o-tolyl ether | 218-645-3 | 2210-79-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 30/06/2014 |
Details | |
Bis(2,6-diisopropylphenyl)carbodiimide | 218-487-5 | 2162-74-5 | Reproductive toxicity (pre-natal developmental toxicity) | 22/09/2022 | 07/11/2022 | Details | |
Dibutyl itaconate | 218-451-9 | 2155-60-4 |
Genetic toxicity in vivo Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
Vinyl laurate | 218-414-7 | 2146-71-6 | Sub-chronic toxicity (90-day): oral | 16/05/2011 | 30/06/2011 | Details | |
N-butyl 4-oxopentanoate | 218-143-4 | 2052-15-5 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Levulinic acid (EC 204-649-2) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Levulinic acid (EC 204-649-2) |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
triethoxy(methyl)silane | 217-983-9 | 2031-67-6 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
triethoxy(methyl)silane | 217-983-9 | 2031-67-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. | 16/10/2014 | 01/12/2014 | Details | |
OO-tert-butyl monoperoxymaleate | 217-691-1 | 1931-62-0 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
1,1'-(1,1,2,2-tetramethylethylene)dibenzene | 217-568-2 | 1889-67-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
N-acetylhexanelactam | 217-565-6 | 1888-91-1 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
6-tert-butyl-2,4-xylenol | 217-533-1 | 1879-09-0 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2021 18/02/2021 |
05/04/2021 05/04/2021 |
Details | |
6-tert-butyl-2,4-xylenol | 217-533-1 | 1879-09-0 | Long-term toxicity to fish | 15/07/2014 | 29/08/2014 | Details | |
1,1,1,3,5,5,5-heptamethyltrisiloxane | 217-496-1 | 1873-88-7 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7 Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
2-ethyl-N,N-bis(2-ethylhexyl)hexylamine | 217-461-0 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/01/2012 16/01/2012 |
01/03/2012 01/03/2012 |
Details | |
Octabenzone | 217-421-2 | 1843-05-6 | Reproductive toxicity (pre-natal developmental toxicity) | 18/02/2013 | 04/04/2013 | Details | |
N-(3-(trimethoxysilyl)propyl)ethylenediamine | 217-164-6 | 1760-24-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
Aminoiminomethanesulphinic acid | 217-157-8 | 1758-73-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 |
Details | |
p-tert-butylstyrene | 217-126-9 | 1746-23-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
chlorodimethylvinylsilane | 217-007-1 | 1719-58-0 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethylsilanol (CAS 1066-40-6) | 12/12/2014 | 26/01/2015 | Details | |
Strontium carbonate | 216-643-7 | 1633-05-2 | Long-term toxicity to fish | 31/05/2011 | 15/07/2011 | Details | |
1-hydroxy-4-[[4-[(methylsulphonyl)oxy]phenyl]amino]anthraquinone | 216-475-4 | 1594-08-7 | Genetic toxicity in vivo | 01/07/2021 | 16/08/2021 | Details | |
[1R-(1α,2β,5α)]-1-(isopropyl)-2-methoxy-4-methylcyclohexane | 216-365-6 | 1565-76-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
Cobalt(2+) propionate | 216-333-1 | 1560-69-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF | 216-036-7 | 1478-61-1 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Aluminium oxide | 215-691-6 | 1344-28-1 | Genetic toxicity in vivo || Note: Testing proposal for two in vivo studies is based on concern identified by the registrant. Testing proposed with Aluminium oxide nanoscale material. | 28/02/2018 | 16/04/2018 | Details | |
Naphthenic acids | 215-662-8 | 1338-24-5 | Long-term toxicity to fish | 01/07/2011 | 15/08/2011 | Details | |
Naphthenic acids | 215-662-8 | 1338-24-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
Dioxydibutane-2,2-diyl dihydroperoxide | 215-661-2 | 1338-23-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 |
Details | |
Tris(methylphenyl) phosphate | 215-548-8 | 1330-78-5 |
Bioaccumulation: aquatic / sediment; Long-term toxicity to fish |
02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 |
Details | |
Xylene | 215-535-7 | 1330-20-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC no. 905-588-0) | 31/01/2023 | 17/03/2023 | Details | |
Xylene | 215-535-7 | 1330-20-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC No 905-588-0) | 01/03/2023 | 17/04/2023 | Details | |
Cobalt sulphide | 215-273-3 | 1317-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
Cobalt sulphide | 215-273-3 | 1317-42-6 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90 day): inhalation
|| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2)
|| Note: Testing proposal is based on concern identified by the registrant |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
Divanadium pentaoxide | 215-239-8 | 1314-62-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with sodium metavanadate (EC no. 237-272-7) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
Ytterbium (III) oxide | 215-234-0 | 1314-37-0 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Zirconium dioxide | 215-227-2 | 1314-23-4 | Reproductive toxicity (pre-natal developmental toxicity) | 15/04/2011 | 30/05/2011 | Details | |
Strontium oxide | 215-219-9 | 1314-11-0 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2019 | 09/08/2019 | Details | |
Manganese dioxide | 215-202-6 | 1313-13-9 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Lithium hydroxide | 215-183-4 | 1310-65-2 | Reproductive toxicity (two-generation reproductive toxicity) | 29/04/2011 | 14/06/2011 | Details | |
Tricobalt tetraoxide | 215-157-2 | 1308-06-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
Tricobalt tetraoxide | 215-157-2 | 1308-06-1 |
Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Cobalt sulphide (EC 215-273-3)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation |
21/09/2020 21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 05/11/2020 |
Details | |
Cobalt oxide | 215-154-6 | 1307-96-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
Cobalt oxide | 215-154-6 | 1307-96-6 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4) Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2) |
21/01/2021 21/01/2021 |
08/03/2021 08/03/2021 |
Details | |
bismuth hydroxide nitrate oxide | 215-136-8 | 1304-85-4 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
Dibismuth trioxide | 215-134-7 | 1304-76-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 |
Details | |
Sodium xylenesulphonate | 215-090-9 | 1300-72-7 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2014 | 29/08/2014 | Details | |
Dichlorobis(η-cyclopentadienyl)titanium | 215-035-9 | 1271-19-8 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
α-methyl-1,3-benzodioxole-5-propionaldehyde | 214-881-6 | 1205-17-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 31/01/2023 | 17/03/2023 | Details | |
4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Trifluoro(trifluoromethoxy)ethylene | 214-703-7 | 1187-93-5 | Sub-chronic toxicity (90 day): inhalation | 29/04/2014 | 13/06/2014 | Details | |
Trimethoxy(methyl)silane | 214-685-0 | 1185-55-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study Reproductive toxicity (pre-natal developmental toxicity) |
12/04/2017 12/04/2017 |
29/05/2017 29/05/2017 |
Details | |
Trimethylamine, N-oxide | 214-675-6 | 1184-78-7 | Genetic toxicity in vivo||Note: testing proposed with Reference substance 001 [CAS No. 62637-93-8] | 06/06/2023 | 21/07/2023 | Details | |
Naphthalene-2,6-dicarboxylic acid | 214-527-0 | 1141-38-4 | Reproductive toxicity (pre-natal developmental toxicity) | 16/06/2022 | 01/08/2022 | Details | |
4-hydroxybenzophenone | 214-507-1 | 1137-42-4 | Genetic toxicity in vivo | 18/02/2021 | 05/04/2021 | Details | |
N-butyl phenyl ether | 214-426-1 | 1126-79-0 | Long-term toxicity to fish | 03/04/2023 | 22/05/2023 | Details | |
Tetradec-1-ene | 214-306-9 | 1120-36-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 25/06/2012 |
15/07/2011 15/07/2011 09/08/2012 |
Details | |
Undecane | 214-300-6 | 1120-21-4 | Reproductive toxicity (two-generation reproductive toxicity) | 25/06/2012 | 09/08/2012 | Details | |
n-butyltin trichloride | 214-263-6 | 1118-46-3 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2011 | 14/06/2011 | Details | |
3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropionate | 214-222-2 | 1115-20-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 15/07/2011 |
Details | |
dimethoxydimethylsilane | 214-189-4 | 1112-39-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
28/11/2022 28/11/2022 |
12/01/2023 12/01/2023 |
Details | |
dimethoxydimethylsilane | 214-189-4 | 1112-39-6 | Sub-chronic toxicity (90 day): inhalation | 16/10/2014 | 01/12/2014 | Details | |
Cyclohexane-1,4-dicarboxylic acid | 214-068-6 | 1076-97-7 | Reproductive toxicity (pre-natal developmental toxicity) | 27/11/2013 | 10/01/2014 | Details | |
Adipohydrazide | 213-999-5 | 1071-93-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2014 31/01/2014 |
17/03/2014 17/03/2014 |
Details | |
tris(2-methoxyethoxy)vinylsilane | 213-934-0 | 1067-53-4 | Reproductive toxicity (pre-natal developmental toxicity) | 29/07/2011 | 12/09/2011 | Details | |
Trimethoxypropylsilane | 213-926-7 | 1067-25-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 |
Details | |
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 213-834-7 | 1025-15-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/09/2012 | 12/11/2012 | Details | |
1-ethoxy-2-(2-methoxyethoxy)ethane | 213-690-5 | 1002-67-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/05/2020 25/05/2020 25/05/2020 |
09/07/2020 09/07/2020 09/07/2020 |
Details | |
1,1,1,3,3,3-hexamethyldisilazane | 213-668-5 | 999-97-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
Methylphosphonic acid | 213-607-2 | 993-13-5 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
bis(piperidinothiocarbonyl) hexasulphide | 213-537-2 | 971-15-3 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 16/02/2015 | 02/04/2015 | Details | |
bis(piperidinothiocarbonyl) hexasulphide | 213-537-2 | 971-15-3 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2014 | 13/06/2014 | Details | |
3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 213-485-0 | 957-68-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/08/2018 10/08/2018 10/08/2018 |
24/09/2018 24/09/2018 24/09/2018 |
Details | |
(1-hydroxycyclohexyl) (phenyl)methanone (hydroxycyclohexyl phenyl ketone) | 213-426-9 | 947-19-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
28/02/2011 28/02/2011 28/02/2011 |
14/04/2011 14/04/2011 14/04/2011 |
Details | |
Hydroxycyclohexyl phenyl ketone | 213-426-9 | 947-19-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/09/2019 | 01/11/2019 | Details | |
N-phenylmaleimide | 213-382-0 | 941-69-5 | Genetic toxicity in vivo | 29/04/2011 | 14/06/2011 | Details | |
2-ethyl-4-methylimidazole | 213-234-5 | 931-36-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
1-(vinyloxy)octadecane | 213-208-3 | 930-02-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
tert-butyl peroxypivalate | 213-147-2 | 927-07-1 | Reproductive toxicity (pre-natal developmental toxicity) | 21/03/2014 | 05/05/2014 | Details | |
Dimethyl(propyl)amine | 213-139-9 | 926-63-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Ethyldimethylamine (EC 209-940-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Ethyldimethylamine (EC 209-940-8) |
18/02/2021 18/02/2021 |
05/04/2021 05/04/2021 |
Details | |
3-aminopropyltriethoxysilane | 213-048-4 | 919-30-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
18/03/2021 18/03/2021 |
03/05/2021 03/05/2021 |
Details | |
Sodium 1-hydroxyethanesulphonate | 213-037-4 | 918-04-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
2,5-bis(1,1,3,3-tetramethylbutyl)hydroquinone | 212-990-3 | 903-19-5 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |