Korábbi/eredmények

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

1 201 - 1 400 / 2 011 tétel megjelenítése.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
Sodium p-cumenesulphonate	239-854-6	15763-76-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Sodium (xylenes and 4-ethylbenzene) sulphonate Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with sodium cumene sulphonate	22/06/2017 22/06/2017	07/08/2017 07/08/2017	Details
bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine	239-816-9	15721-78-5	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014 18/02/2014	04/04/2014 04/04/2014 04/04/2014	Details
2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate	239-701-3	15625-89-5	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral	25/05/2020 25/05/2020	09/07/2020 09/07/2020	Details
2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate	239-701-3	15625-89-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/10/2022	12/12/2022	Details
2,2'-azobis[4-methoxy-2,4-dimethylvaleronitrile]	239-593-8	15545-97-8	Genetic toxicity in vivo	17/06/2020	03/08/2020	Details
Diphosphoric acid, compound with 1,3,5-triazine-2,4,6-triamine	239-590-1	15541-60-3	Reproductive toxicity (pre-natal developmental toxicity)	26/08/2021	11/10/2021	Details
bis(4-tert-butylcyclohexyl) peroxydicarbonate	239-557-1	15520-11-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
2,2'-(octylimino)bisethanol	239-555-0	15520-05-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/11/2019 25/11/2019	09/01/2020 09/01/2020	Details
3-(trimethoxysilyl)propyl isocyanate	239-415-9	15396-00-6	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: it is proposed to use the information from an ongoing study with 3-(trimethoxysilyl)propylamine (EC 237-511-5)	30/09/2021 30/09/2021	15/11/2021 15/11/2021	Details
(chloromethyl)triethoxysilane	239-311-3	15267-95-5	Genetic toxicity in vivo	16/10/2014	01/12/2014	Details
sodium 1H-benzotriazolide	239-269-6	15217-42-2	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with 1H-Benzotriazole (EC 202-394-1)	16/12/2016	30/01/2017	Details
Methyl benzoylformate	239-263-3	15206-55-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/10/2022 26/10/2022	12/12/2022 12/12/2022	Details
bismuth oxide salicylate	238-953-1	14882-18-9	Sub-chronic toxicity (90 day): oral \|\| Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8)	18/09/2014	03/11/2014	Details
Ethylenediamine, salt with phosphoric acid	238-914-9	14852-17-6	Reproductive toxicity (extended one-generation reproductive toxicity study)	27/01/2020	12/03/2020	Details
3-(triethoxysilyl)propanethiol	238-883-1	14814-09-6	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/10/2014 16/10/2014 16/10/2014	01/12/2014 01/12/2014 01/12/2014	Details
N,N-dimethyldecan-1-amide	238-405-1	14433-76-2	Long-term toxicity to fish	15/07/2011	29/08/2011	Details
Zinc bis(diethyldithiocarbamate)	238-270-9	14324-55-1	Reproductive toxicity (extended one-generation reproductive toxicity study)	10/08/2018	24/09/2018	Details
Lithium tetrafluoroborate, anhydrous	238-178-9	14283-07-9	Genetic toxicity in vivo	25/05/2020	09/07/2020	Details
potassium tetrafluoroborate	237-928-2	14075-53-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
Cobalt(II) 4-oxopent-2-en-2-olate	237-855-6	14024-48-7	"Carcinogenicity \|\| Note: testing proposed with Cobalt dichloride (EC 231-589-4) \|\| Note: Testing proposal is based on concern identified by the registrant. " Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant.	21/09/2020 21/09/2020	05/11/2020 05/11/2020	Details
Cobalt(II) 4-oxopent-2-en-2-olate	237-855-6	14024-48-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
Potassium dicyanoaurate	237-748-4	13967-50-5	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	17/06/2020	03/08/2020	Details
Tetraammineplatinum dichloride	237-706-5	13933-32-9	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	28/02/2018	16/04/2018	Details
Tetraammineplatinum dichloride	237-706-5	13933-32-9	Genetic toxicity in vivo	25/11/2021	10/01/2022	Details
Bis(dibutyldithiocarbamato-S,S')copper	237-695-7	13927-71-4	Long-term toxicity to fish	22/06/2017	07/08/2017	Details
3-(trimethoxysilyl)propylamine	237-511-5	13822-56-5	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/04/2019 26/04/2019	10/06/2019 10/06/2019	Details
3,5-dimethyl-1,2-dioxolane-3,5-diol	237-438-9	13784-51-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	01/09/2017 01/09/2017	16/10/2017 16/10/2017	Details
Sodium metavanadate	237-272-7	13718-26-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	25/01/2022 25/01/2022	11/03/2022 11/03/2022	Details
Magnesium metaborate	237-235-5	13703-82-7	Reproductive toxicity (pre-natal developmental toxicity)	25/11/2021	10/01/2022	Details
Divanadium tris(sulphate)	237-226-6	13701-70-7	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with Sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)	30/06/2023 30/06/2023	14/08/2023 14/08/2023	Details
Barium diboron tetraoxide	237-222-4	13701-59-2	Reproductive toxicity (two-generation reproductive toxicity)	16/05/2014	30/06/2014	Details
4,4'-methylenebis[2,6-diethylaniline]	237-185-4	13680-35-8	Genetic toxicity in vivo Long-term toxicity to fish	26/03/2018 26/03/2018	11/05/2018 11/05/2018	Details
1,1'-(methylenedi-p-phenylene)bismaleimide	237-163-4	13676-54-5	Reproductive toxicity (pre-natal developmental toxicity)	30/09/2021	15/11/2021	Details
Stearic acid, cobalt salt	237-016-4	13586-84-0	Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Neodecanoic acid, cobalt salt (EC no. 248-373-0)	28/11/2022	12/01/2023	Details
Stearic acid, cobalt salt	237-016-4	13586-84-0	Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2)	21/01/2021	08/03/2021	Details
(3-chloropropyl)diethoxymethylsilane	236-828-6	13501-76-3	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3)	17/04/2015	04/06/2015	Details
Bis(triethoxysilylpropyl)amine	236-818-1	13497-18-2	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Bis(trimethoxysilylpropyl)amine (EC 403-480-3) \|\| Note: Testing proposal is based on concern identified by the registrant	07/07/2020	21/08/2020	Details
Bis(triethoxysilylpropyl)amine	236-818-1	13497-18-2	Sub-chronic toxicity (90-day): oral	22/09/2022	07/11/2022	Details
2,2'-azobis[2-methylbutyronitrile]	236-740-8	13472-08-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014 03/03/2014	17/04/2014 17/04/2014 17/04/2014	Details
(octadecanoato-O)oxoaluminium	236-521-7	13419-15-3	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7)	30/11/2015	14/01/2016	Details
2,2'-[(1-methylethylidene)bis(cyclohexane-4,1-diyloxymethylene)]bisoxirane	236-502-3	13410-58-7	Genetic toxicity in vivo	22/04/2021	07/06/2021	Details
tetradecahydro-7-isopropyl-1,4a-dimethylphenanthren-1-methanol	236-476-3	13393-93-6	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014 18/02/2014	04/04/2014 04/04/2014 04/04/2014	Details
Sodium diisobutyldithiophosphinate	236-419-2	13360-78-6	Reproductive toxicity (pre-natal developmental toxicity) with Rat Sub-chronic toxicity (90-day): oral	24/07/2019 24/07/2019	09/09/2019 09/09/2019	Details
5-amino-2-nitrobenzoic acid	236-283-4	13280-60-9	Genetic toxicity in vivo	25/01/2022	11/03/2022	Details
N-octadecylstearamide	236-276-6	13276-08-9	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity)	17/04/2015 17/04/2015 17/04/2015	04/06/2015 04/06/2015 04/06/2015	Details
Zinc methacrylate	236-144-8	13189-00-9	Genetic toxicity in vivo	01/03/2023	17/04/2023	Details
N-vinylformamide	236-102-9	13162-05-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/11/2015	16/12/2015	Details
N-vinylformamide	236-102-9	13162-05-5	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011 01/07/2011	15/08/2011 15/08/2011	Details
tert-butyl 3,5,5-trimethylperoxyhexanoate	236-050-7	13122-18-4	Genetic toxicity in vivo	18/02/2021	05/04/2021	Details
tert-butyl 3,5,5-trimethylperoxyhexanoate	236-050-7	13122-18-4	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/04/2011 15/04/2011 15/04/2011	30/05/2011 30/05/2011 30/05/2011	Details
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate)	235-935-5	13052-09-0	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates	12/12/2014	26/01/2015	Details
1,10-decanediyl diacrylate	235-922-4	13048-34-5	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) Sub-chronic toxicity (90-day): oral\|\|Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2)	06/06/2023 06/06/2023 06/06/2023	21/07/2023 21/07/2023 21/07/2023	Details
Phosphoric acid, butyl ester	235-826-2	12788-93-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	17/04/2015 17/04/2015	04/06/2015 04/06/2015	Details
Hexaboron dizinc undecaoxide	235-804-2	12767-90-7	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	25/11/2019	09/01/2020	Details
Hexaboron dizinc undecaoxide	235-804-2	12767-90-7	Carcinogenicity study Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	29/04/2011 29/04/2011 29/04/2011 29/04/2011	14/06/2011 14/06/2011 14/06/2011 14/06/2011	Details
Phosphoric acid, 2-ethylhexyl ester	235-741-0	12645-31-7	Reproductive toxicity (pre-natal developmental toxicity)	25/05/2020	09/07/2020	Details
Cyclohexanone, peroxide	235-527-7	12262-58-7	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide	235-425-2	12225-06-8	7.5.2 Repeated dose toxicity: inhalation 7.8.2 Developmental toxicity / teratogenicity	08/03/2024 08/03/2024	22/04/2024 22/04/2024	Details
Cobalt lithium dioxide	235-362-0	12190-79-3	Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation \|\| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) \|\| Note: Testing proposal is based on concern identified by the registrant.	21/09/2020 21/09/2020	05/11/2020 05/11/2020	Details
barium titanium trioxide	234-975-0	12047-27-7	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	17/04/2015 17/04/2015	04/06/2015 04/06/2015	Details
praseodymium(III,IV) oxide	234-857-9	12037-29-5	Genetic toxicity in vivo	18/09/2014	03/11/2014	Details
Vanadium dioxide	234-841-1	12036-21-4	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: : testing proposed with Sodium metavanadate (EC no. 237-272-7) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)	16/06/2022 16/06/2022	01/08/2022 01/08/2022	Details
Cobalt hydroxide oxide	234-614-7	12016-80-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
Cobalt hydroxide oxide	234-614-7	12016-80-7	Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Cobalt sulphide (EC 215-273-3) \|\| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90 day): inhalation \|\| Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) \|\| Note: Testing proposal is based on concern identified by the registrant	21/09/2020 21/09/2020 21/09/2020	05/11/2020 05/11/2020 05/11/2020	Details
Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer	234-293-3	11071-15-1	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity)	25/05/2020 25/05/2020	09/07/2020 09/07/2020	Details
Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate)	234-277-6	11059-65-7	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
Methyl trimethyl-3-[(1-oxododecyl)amino]propylammonium sulphate	234-204-8	10595-49-0	Reproductive toxicity (pre-natal developmental toxicity)	16/12/2020	01/02/2021	Details
N,N'-dimethyldiphenylthiuram disulphide	234-196-6	10591-84-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2019 16/08/2019	30/09/2019 30/09/2019	Details
N,N'-bis(3-aminopropyl)ethylenediamine	234-147-9	10563-26-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/03/2021 18/03/2021	03/05/2021 03/05/2021	Details
Dirhodium trisulphate	234-014-5	10489-46-0	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
2-aminoethanol, monoester with boric acid	233-829-3	10377-81-8	Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011	Details
2-aminoethanol, monoester with boric acid	233-829-3	10377-81-8	Sub-chronic toxicity (90-day): oral	17/11/2011	02/01/2012	Details
Bismuth trinitrate	233-791-8	10361-44-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8)	20/09/2013 20/09/2013	04/11/2013 04/11/2013	Details
Barium chloride	233-788-1	10361-37-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/03/2018	11/05/2018	Details
Barium chloride	233-788-1	10361-37-2	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	29/04/2011 29/04/2011 29/04/2011	14/06/2011 14/06/2011 14/06/2011	Details
Ethyl 4-dimethylaminobenzoate	233-634-3	10287-53-3	Long-term toxicity to fish Sub-chronic toxicity (90-day): oral	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
2,2'-(octadecylimino)bisethanol	233-520-3	10213-78-2	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 2,2'-(octadec-9-enylimino)bisethanol EC 246-807-3	16/12/2020	01/02/2021	Details
Cobalt (II) dinitrate	233-402-1	10141-05-6	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
cobalt dinitrate	233-402-1	10141-05-6	Carcinogenicity \|\| Note: testing proposed with Cobalt dichloride (EC 231-589-4) Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2)	21/01/2021 21/01/2021	08/03/2021 08/03/2021	Details
Cobalt (II) sulphate	233-334-2	10124-43-3	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) ; after obtaining results of the 90-day subchronic toxicity study Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
cobalt sulphate	233-334-2	10124-43-3	Carcinogenicity \|\| Note: testing proposed with Cobalt dichloride (EC 231-589-4) Genetic toxicity in vivo	21/01/2021 21/01/2021	08/03/2021 08/03/2021	Details
cerium trinitrate	233-297-2	10108-73-3	Reproductive toxicity (pre-natal developmental toxicity)	17/04/2015	04/06/2015	Details
Sodium permanganate	233-251-1	10101-50-5	Reproductive toxicity (pre-natal developmental toxicity)	15/04/2011	30/05/2011	Details
a,a-dimethylphenethyl butyrate	233-221-8	10094-34-5	Reproductive toxicity (pre-natal developmental toxicity)“\|\| Note: testing proposed 1,1-Dimethyl-2-phenylethyl acetate (EC 205-781-3)” Sub-chronic toxicity (90-day): oral“\|\| Note: testing proposed 1,1-Dimethyl-2-phenylethyl acetate (EC 205-781-3)”	22/11/2017 22/11/2017	08/01/2018 08/01/2018	Details
4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline	233-215-5	10081-67-1	Sub-chronic toxicity (90-day): oral	18/02/2014	04/04/2014	Details
Strontium nitrate	233-131-9	10042-76-9	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	31/05/2011 31/05/2011 31/05/2011	15/07/2011 15/07/2011 15/07/2011	Details
Dipotassium tetrachloroplatinate	233-050-9	10025-99-7	Genetic toxicity in vivo \|\| Note: "Testing proposal is based on concern identified by the registrant."	18/06/2018	02/08/2018	Details
Resin acids and Rosin acids, calcium salts	232-694-8	9007-13-0	Reproductive toxicity (pre-natal developmental toxicity)	06/03/2012	20/04/2012	Details
Resin acids and Rosin acids, calcium salts	232-694-8	9007-13-0	Reproductive toxicity (pre-natal developmental toxicity \|\| Note: Testing proposed with Rosin CAS 8050-09-7 Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: Testing proposed with Rosin CAS 8050-09-7 Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposed with Rosin CAS 8050-09-7, Rosin hydrogenated CAS 65997-06-0, and Rosin reaction products with formaldehyde CAS 91081-53-7	02/07/2013 02/07/2013 02/07/2013	16/08/2013 16/08/2013 16/08/2013	Details
ASPHALT	232-490-9	8052-42-4	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	31/05/2016 31/05/2016	15/07/2016 15/07/2016	Details
Asphalt	232-490-9	8052-42-4	Reproductive toxicity (extended one-generation reproductive toxicity study) [note whilst the registrant has selected the drop down of a RaX TPE – it is not a RaX TPE – registered substance is being tested]”	25/06/2019	09/08/2019	Details
Asphalt	232-490-9	8052-42-4	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	04/12/2023 04/12/2023 04/12/2023 04/12/2023	18/01/2024 18/01/2024 18/01/2024 18/01/2024	Details
Resin acids and Rosin acids, esters with glycerol	232-482-5	8050-31-5	Reproductive toxicity (pre-natal developmental toxicity)	06/03/2012	20/04/2012	Details
Resin acids and Rosin acids, esters with glycerol	232-482-5	8050-31-5	Reproductive toxicity (pre-natal developmental toxicity)\|\| Note: Testing proposed to be carried out with Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: testing proposed with Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7), Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7)	02/07/2013 02/07/2013 02/07/2013	16/08/2013 16/08/2013 16/08/2013	Details
Rosin, maleated	232-480-4	8050-28-0	Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0) Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7) Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and the registered substance	02/07/2013 02/07/2013 02/07/2013	16/08/2013 16/08/2013 16/08/2013	Details
Rosin, maleated	232-480-4	8050-28-0	Reproductive toxicity (pre-natal developmental toxicity)	06/03/2012	20/04/2012	Details
Resin acids and Rosin acids, esters with pentaerythritol	232-479-9	8050-26-8	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (pre-natal developmental toxicity)\|\| Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: Testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)	06/03/2012 02/07/2013 02/07/2013 02/07/2013	20/04/2012 16/08/2013 16/08/2013 16/08/2013	Details
Resin acids and Rosin acids, esters with triethylene glycol	232-478-3	8050-25-7	Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) and Rosin, triethylene glycol ester (CAS RN 8050-25-7) Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)	02/07/2013 02/07/2013 02/07/2013	16/08/2013 16/08/2013 16/08/2013	Details
Resin acids and Rosin acids, esters with triethylene glycol	232-478-3	8050-25-7	Reproductive toxicity (pre-natal developmental toxicity)	06/03/2012	20/04/2012	Details
Resin acids and Rosin acids, hydrogenated, Me esters	232-476-2	8050-15-5	Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)	02/07/2013	16/08/2013	Details
Rosin	232-475-7	8050-09-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposed with rosin CAS 8050-09-7; Rosin, hydrogenated (CAS RN 65997-06-0), Rosin, reaction products with formaldehyde (CAS RN 91081-53-7)	06/03/2012 02/07/2013 02/07/2013 02/07/2013	20/04/2012 16/08/2013 16/08/2013 16/08/2013	Details
Alcohols, lanolin	232-430-1	8027-33-6	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
2,7-naphthalenedisulfonic acid, 4-amino-5-hydroxy-, diazotized, coupled with diazotized 2-amino-4,6-dinitrophenol, diazotized 4-nitrobenzenamine and resorcinol, sodium salts	232-380-0	8011-86-7	Genetic toxicity in vivo	21/10/2021	07/12/2021	Details
Cashew, nutshell liq.	232-355-4	8007-24-7	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/09/2011 15/09/2011 15/09/2011 15/09/2011	31/10/2011 31/10/2011 31/10/2011 31/10/2011	Details
Terpineol	232-268-1	8000-41-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011 01/07/2011	15/08/2011 15/08/2011	Details
Terpineol	232-268-1	8000-41-7	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/09/2017	16/10/2017	Details
Strontium chromate	232-142-6	7789-06-2	Long-term toxicity to fish	31/05/2011	15/07/2011	Details
dichloro(3-chloropropyl)methylsilane	232-136-3	7787-93-1	Reproductive toxicity (pre-natal developmental toxicity)\|\| Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6, CAS 5089-70-3)	16/10/2014	01/12/2014	Details
(-)-pin-2(3)-ene	232-077-3	7785-26-4	Reproductive toxicity (pre-natal developmental toxicity)	25/10/2017	11/12/2017	Details
Multi-Wall Carbon Nanotubes, synthetic graphite in tubular shape	231-955-3	7782-42-5	Long-term toxicity to fish	03/11/2011	19/12/2011	Details
Silver nitrate	231-853-9	7761-88-8	Sub-chronic toxicity (90-day): oral	16/06/2011	01/08/2011	Details
Pentasodium triphosphate	231-838-7	7758-29-4	Sub-chronic toxicity (90-day) via the inhalatory route (rat)	08/04/2010	24/05/2010	Details
Barium sulfate	231-784-4	7727-43-7	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Barium chloride (EC 233-788-1)	17/06/2020	03/08/2020	Details
Barium sulfate	231-784-4	7727-43-7	Long-term toxicity to fish	29/04/2011	14/06/2011	Details
Potassium permanganate	231-760-3	7722-64-7	Reproductive toxicity (two-generation reproductive toxicity)	14/02/2011	31/03/2011	Details
N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine	231-701-1	7691-02-3	Reproductive toxicity (pre-natal developmental toxicity) “\|\| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” Sub-chronic toxicity (90 day): inhalation “\|\| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”	12/12/2014 12/12/2014	26/01/2015 26/01/2015	Details
Sodium phosphinate	231-669-9	7681-53-0	Reproductive toxicity (developmental toxicity)	26/01/2011	14/03/2011	Details
cobalt dichloride	231-589-4	7646-79-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	18/07/2016 18/07/2016	01/09/2016 01/09/2016	Details
COBALT DICHLORIDE	231-589-4	7646-79-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	29/04/2016 29/04/2016	13/06/2016 13/06/2016	Details
Cobalt dichloride	231-589-4	7646-79-9	Carcinogenicity \|\| Note: Testing proposal is based on concern identified by the registrant. Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant.	21/09/2020 21/09/2020	05/11/2020 05/11/2020	Details
Cobalt dichloride	231-589-4	7646-79-9	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
Boron trifluoride	231-569-5	-	Genetic toxicity in vivo	01/07/2011	15/08/2011	Details
Pentaerythritol tetrakis(3-mercaptopropionate)	231-472-8	7575-23-7	Long-term toxicity to fish	01/07/2021	16/08/2021	Details
Pentaerythritol tetrakis(3-mercaptopropionate)	231-472-8	7575-23-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011	Details
Sodium dihydrogenorthophosphate	231-449-2	7558-80-7	Sub-chronic toxicity (90-day): oral	24/07/2019	09/09/2019	Details
Sodium dihydrogenorthophosphate	231-449-2	7558-80-7	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/09/2016	17/10/2016	Details
4-methylmorpholine 4-oxide, monohydrate	231-391-8	7529-22-8	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	16/02/2015 16/02/2015 16/02/2015	02/04/2015 02/04/2015 02/04/2015	Details
2-hydroxy-2-methylpropiophenone	231-272-0	7473-98-5	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day)	21/10/2019 15/03/2011 15/03/2011 15/03/2011	05/12/2019 29/04/2011 29/04/2011 29/04/2011	Details
Lithium chloride	231-212-3	7447-41-8	Genetic toxicity in vivo	03/11/2023	18/12/2023	Details
Lithium chloride	231-212-3	7447-41-8	Reproductive toxicity (two-generation reproductive toxicity)	29/04/2011	14/06/2011	Details
tellurium dioxide	231-193-1	7446-07-3	Sub-chronic toxicity (90-day): oral	16/03/2015	30/04/2015	Details
Dimethyl (p-methoxybenzylidene)malonate	231-185-8	7443-25-6	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	23/03/2020	07/05/2020	Details
Bismuth	231-177-4	7440-69-9	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
Cobalt	231-158-0	7440-48-4	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
Cobalt	231-158-0	7440-48-4	Carcinogenicity \|\| Note: testing proposed with Cobalt dichloride (EC 231-589-4) \|\| Note: Testing proposal is based on concern identified by the registrant. Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant.	21/09/2020 21/09/2020	05/11/2020 05/11/2020	Details
Silver	231-131-3	7440-22-4	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with silver(1+) acetate (CAS number 563-63-3)	27/09/2017	13/11/2017	Details
Silver	231-131-3	7440-22-4	Sub-chronic toxicity (90-day): oral	29/04/2011	14/06/2011	Details
Silicon	231-130-8	7440-21-3	Subchronic toxicity (90 day): inhalation	14/02/2011	31/03/2011	Details
Nickel	231-111-4	7440-02-0	Reproductive toxicity (extended one-generation reproductive toxicity study)	28/02/2019	15/04/2019	Details
Butyl glycollate	230-991-7	7397-62-8	Sub-chronic toxicity (90-day): oral	15/04/2011	30/05/2011	Details
Aluminum triformate	230-898-1	7360-53-4	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity study (90-day): oral	21/01/2011 21/01/2011 21/01/2011	07/03/2011 07/03/2011 07/03/2011	Details
tetrapotassium pyrophosphate	230-785-7	7320-34-5	Sub-chronic toxicity (90 day): inhalation	01/07/2011	15/08/2011	Details
Bis(2,3-epoxypropyl) terephthalate	230-565-0	7195-44-0	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	16/05/2012 16/05/2012 16/05/2012	02/07/2012 02/07/2012 02/07/2012	Details
2-(dimethylamino)-2-methylpropan-1-ol	230-279-6	7005-47-2	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2014	17/03/2014	Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate)	230-257-6	6990-43-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate)	230-257-6	6990-43-8	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate	229-934-9	6846-50-0	Reproductive toxicity (pre-natal developmental toxicity)	14/03/2016	28/04/2016	Details
dimethoxydiphenylsilane	229-929-1	6843-66-9	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
14H-benz[4,5]isoquino[2,1-a]perimidin-14-one	229-904-5	6829-22-7	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
[3aR-(3aα,5aβ,9aα,9bβ)]-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan	229-861-2	6790-58-5	Long-term toxicity to fish	22/09/2022	07/11/2022	Details
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide	229-782-3	6731-36-8	Reproductive toxicity (pre-natal developmental toxicity)	01/07/2011	15/08/2011	Details
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide	229-782-3	6731-36-8	Bioaccumulation aquatic / sediment	01/04/2022	16/05/2022	Details
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide	229-782-3	6731-36-8	Bioaccumulation aquatic / sediment	25/06/2019	09/08/2019	Details
N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine	229-761-9	6711-48-4	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with N,N-diethylpropane-1,3-diamine (EC no. 203-236-4)	22/09/2022	07/11/2022	Details
1,8-diazabicyclo[5.4.0]undec-7-ene	229-713-7	6674-22-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
4-methylthiosemicarbazide	229-563-2	6610-29-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane	229-542-8	6600-31-3	Reproductive toxicity (pre-natal developmental toxicity)	15/07/2014	29/08/2014	Details
Hydrogen [4-[[4-(diethylamino)phenyl][4-[ethyl[(3-sulphonatobenzyl)amino]-o-tolyl]methylene]-3-methylcyclohexa-2,5-dien-1-ylidene](ethyl)(3-sulphonatobenzyl)ammonium, sodium salt	229-390-2	6505-30-2	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	23/11/2020	07/01/2021	Details
Disodium 4-amino-3,6-bis[[4-[(2,4-diaminophenyl)azo]phenyl]azo]-5-hydroxynaphthalene-2,7-disulphonate	229-208-1	6428-31-5	Genetic toxicity in vivo	01/07/2021	16/08/2021	Details
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene	228-846-8	6362-80-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
Sodium hydrogen-5-sulphoisophthalate	228-845-2	6362-79-4	Genetic toxicity in vivo	29/04/2014	13/06/2014	Details
Sodium hydrogen-5-sulphoisophthalate	228-845-2	6362-79-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	22/04/2021 22/04/2021	07/06/2021 07/06/2021	Details
2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide	228-768-4	6358-31-2	7.5.2 Repeated dose toxicity: inhalation	08/03/2024	22/04/2024	Details
Hexyl salicylate	228-408-6	6259-76-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): oral	18/02/2021 18/02/2021	05/04/2021 05/04/2021	Details
2,4,6,8,10-pentamethylcyclopentasiloxane	228-204-7	6166-86-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4)	25/05/2020	09/07/2020	Details
2,4,6,8,10-pentamethylcyclopentasiloxane	228-204-7	6166-86-5	Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9) Sub-chronic toxicity (90 day): inhalation \|\| Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)	04/10/2013 04/10/2013	18/11/2013 18/11/2013	Details
2,4,6,8,10-pentamethylcyclopentasiloxane	228-204-7	6166-86-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)	31/01/2018 31/01/2018	19/03/2018 19/03/2018	Details
(R)-p-mentha-1,8-diene	227-813-5	5989-27-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/05/2020	09/07/2020	Details
trichloro(hexadecyl)silane	227-575-2	5894-60-0	Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6) Sub-chronic toxicity (90-day): oral Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
N,N'-hexane-1,6-diylbis(hexahydro-2-oxo-1H-azepine-1-carboxamide)	227-563-7	5888-87-9	Genetic toxicity in vivo	18/09/2014	03/11/2014	Details
o-(p-isocyanatobenzyl)phenyl isocyanate	227-534-9	5873-54-1	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0)	01/04/2022	16/05/2022	Details
1,1,3,3-tetramethylbutyl hydroperoxide	227-369-2	5809-08-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
dichlorocyclohexylmethylsilane	226-956-0	5578-42-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with [dicyclopentyldimethoxysilane] (CAS 126990-35-0)	16/03/2015	30/04/2015	Details
2-ethylhexyl benzoate	226-641-8	5444-75-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014 02/06/2014	17/07/2014 17/07/2014 17/07/2014	Details
Guanidinium phosphate (1:1)	226-551-9	5423-22-3	Sub-chronic toxicity (90-day): oral	16/05/2014	30/06/2014	Details
Citral	226-394-6	5392-40-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	28/02/2018	16/04/2018	Details
4,4'-methylenedi-2,6-xylenol	226-378-9	5384-21-4	Reproductive toxicity (extended one-generation reproductive toxicity study)	03/04/2023	22/05/2023	Details
Pentane-1,2-diol	226-285-3	5343-92-0	Sub-chronic toxicity (90-day): oral	16/06/2011	01/08/2011	Details
2-Octyldodecan-1-ol	226-242-9	5333-42-6	Reproductive toxicity (two-generation reproductive toxicity)	05/04/2011	20/05/2011	Details
Sulphamidic acid	226-218-8	5329-14-6	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with ammonium sulphamate (pH consideration)	23/04/2018	07/06/2018	Details
Sulphamidic acid	226-218-8	5329-14-6	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	14/02/2011 14/02/2011 14/02/2011	31/03/2011 31/03/2011 31/03/2011	Details
Sulphamidic acid	226-218-8	5329-14-6	Reproductive toxicity (pre-natal developmental toxicity)	25/11/2021	10/01/2022	Details
4,4'-methylenebis[N-sec-butylaniline]	226-122-6	5285-60-9	Bioaccumulation aquatic / sediment	27/01/2020	12/03/2020	Details
octyltrichlorosilane	226-112-1	5283-66-9	Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3)	25/06/2015	10/08/2015	Details
4-[3-(1-naphthylamino)propyl]morpholine	226-033-2	5235-82-5	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
Etocrilene	226-029-0	5232-99-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	24/02/2020 24/02/2020	09/04/2020 09/04/2020	Details
N-[3-(dimethylamino)propyl]methacrylamide	226-002-3	5205-93-6	Reproductive toxicity (pre-natal developmental toxicity)	29/04/2011	14/06/2011	Details
5-ethyl-1,3-dioxane-5-methanol	225-967-8	5187-23-5	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	03/10/2023 03/10/2023 03/10/2023	17/11/2023 17/11/2023 17/11/2023	Details
5-ethyl-1,3-dioxane-5-methanol	225-967-8	5187-23-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	31/01/2014 31/01/2014	17/03/2014 17/03/2014	Details
(3-chloropropyl)triethoxysilane	225-805-6	5089-70-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/10/2022 26/10/2022	12/12/2022 12/12/2022	Details
N-isopropylhydroxylamine	225-791-1	5080-22-8	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014 18/02/2014	04/04/2014 04/04/2014 04/04/2014	Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline	225-716-2	5026-74-4	Genetic toxicity in vivo \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)	15/07/2014 15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014 29/08/2014	Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline	225-716-2	5026-74-4	Genetic toxicity in vivo \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)	15/07/2014 15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014 29/08/2014	Details
N-(3-aminopropyl)iminodiethanol	225-642-0	4985-85-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
2,2-bis(hydroxymethyl)propionic acid // 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid	225-306-3	-	Reproductive toxicity (pre-natal developmental toxicity study) Sub-chronic oral toxicity (90-day): oral	05/04/2011 05/04/2011	20/05/2011 20/05/2011	Details
Octylphosphonic acid	225-218-5	4724-48-5	Reproductive toxicity (pre-natal developmental toxicity)	16/05/2014	30/06/2014	Details
Octylphosphonic acid	225-218-5	4724-48-5	Sub-chronic toxicity (90-day): oral	03/04/2023	22/05/2023	Details
2,2'-(cyclohexylimino)bisethanol	224-809-5	4500-29-2	Reproductive toxicity (pre-natal developmental toxicity)	17/09/2019	01/11/2019	Details
3-methylpentane-1,5-diol	224-709-1	4457-71-0	Long-term toxicity to fish	01/03/2023	17/04/2023	Details
3-trimethoxysilylpropane-1-thiol	224-588-5	4420-74-0	Long-term toxicity to fish\|\|Note: testing proposed with 3-Triethoxysilylpropane-1-thiol (EC no. 238-883-1)	22/09/2022	07/11/2022	Details

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