Προηγούμενες/Αποτελέσματα

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Εμφάνιση 1 - 200 από 2.011 αποτελέσματα.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives	-	-	Sub-chronic toxicity (90-day): oral	30/06/2016	15/08/2016	Details
3,5-bis(2,4-dimethylcyclohex-3-en-1-yl)polyheterocycle	-	-	Genetic toxicity in vivo	16/03/2015	30/04/2015	Details
3-[(diisoalkyloxyphosphorothioyl)thio]-2-methylalkanoic acid	-	-	Developmental toxicity (pre-natal developmental toxicity)	15/03/2011	29/04/2011	Details
Addition products of m-phenylenebis(methylamine) with reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethyl 5-isocyanato-2-methylphenylcarbamate, 2-(2-(2-butoxyethoxy)ethoxy)ethyl 3-isocyanato-4-methylphenylcarbamate and 2-(2-(2-butoxyethoxy)ethoxy)ethyl 3-isocyanato-2-methylphenylcarbamate	-	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: Testing proposal is based on potential concern identified by the registrant. Sub-chronic toxicity (90 day): oral	15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014	Details
Alkenes, C13-14	-	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
Alkenes, C13-14, hydroformylation products, low boiling	-	-	Reproductive toxicity (two-generation reproductive toxicity)	29/07/2011	12/09/2011	Details
Alkenes, C6-8, even and odd, linear and branched	-	-	Sub-chronic toxicity (90-day): oral	25/06/2012	09/08/2012	Details
Alkenes, C6-8, even and odd, linear and branched	-	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
alkoxy substituted aryl diazo heterocyclic aryl nitrile	-	-	Genetic toxicity in vivo	31/01/2023	17/03/2023	Details
alkyl amine and alkylbenzenesulphonate	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/03/2018 26/03/2018	11/05/2018 11/05/2018	Details
Aluminium tris(dialkylphosphinate)	-	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	23/06/2011 23/06/2011	08/08/2011 08/08/2011	Details
Amides, C18 (unsaturated)	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011	30/09/2011 30/09/2011	Details
Amides, C22 (unsaturated)	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011	30/09/2011 30/09/2011	Details
Amides, C8-18(even-numbered) and C18(unsatd.), N-(2-hydroxypropyl)	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011	30/09/2011 30/09/2011	Details
Bis(nonylphenyl)amine / Reaction products of Benzeneamine, N-phenyl- with nonene (branched)	-	-	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	28/02/2011 28/02/2011	14/04/2011 14/04/2011	Details
boron orthophosphate	-	13308-51-5	Reproductive toxicity (pre-natal developmental toxicity)	30/06/2016	15/08/2016	Details
Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distilled	-	-	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014 29/08/2014	Details
Cashew, nutshell liq., oligomeric reaction products with 1-chloro-2,3-epoxypropane	-	68413-24-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
Condensation products of triethanolamine with addition products of fatty acids, C18 (unsaturated) alkyl with maleic anhydride	-	-	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	10/03/2017 10/03/2017 10/03/2017	25/04/2017 25/04/2017 25/04/2017	Details
Coupling reaction products of diazotized 2-amino-6-[(2-substituted ethyl)sulfonyl]naphthalene-1-subsituted acid with 4-({4-chloro-6-[ethyl(3-{[2-(substituted oxy)ethyl]sulfonyl}phenyl)amino]-heteromonocycl-2-yl}amino)-5-hydroxynaphthalene-2,7-disubstituted acid and their sodium and potassium salts	-	-	7.6.2 Mammalian erythrocyte micronucleus test according to OECD 474	03/12/2010	17/01/2011	Details
Disodium hydroxy-substituted alkanoate	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
Ethanaminium, 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-, esters with C16-18 and C18 unsatd. fatty acids, chlorides	-	1079184-43-2	Reproductive toxicity (two-generation reproductive toxicity)	26/04/2010	10/06/2010	Details
Ethoxypropyl-hydroxy-hexanamide	-	-	Reproductive/developmental toxicity	04/12/2009	18/01/2010	Details
Fatty acids, C14-18 and C16-18-unsatd., maleated	-	85711-46-2	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	11/11/2016 11/11/2016 11/11/2016	03/01/2017 03/01/2017 03/01/2017	Details
Halophosphate	-	-	Sub-chronic toxicity (90 day): inhalation	15/07/2014	29/08/2014	Details
Hydrogenated oligomerisation product, including dimers and trimers, of tetradec-1-ene and alkene	-	-	Reproductive toxicity (developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	10/08/2009 10/08/2009	24/09/2009 24/09/2009	Details
isliFe	-	-	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	17/12/2019	31/01/2020	Details
N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
Polar modified Rice Bran Wax	-	-	Reproductive toxicity (pre-natal developmental toxicity)	03/05/2023	19/06/2023	Details
Poly(alkan-2-yl)heteropolycycle	-	-	Genetic toxicity in vivo	31/01/2013	18/03/2013	Details
Polysulfo {5-hydroxy-1-naphthalen-2-yl-[4-[4-(2-sulfatoethyl-sulfonyl)-phenyl]diazenyl]-1H-pyrazole-3-carboxylic acid}, alkali metal salt	-	-	Genetic toxicity in vivo	09/11/2009	24/12/2009	Details
Raffinates (Fischer-Tropsch), C10-25-branched	-	1345668-40-7	Reproductive toxicity (two-generation reproductive toxicity)	17/08/2012	01/10/2012	Details
Reaction mass of disodium hydroxysulfinatoacetate and disodium hydroxysulfonatoacetate	-	-	Reproductive toxicity (developmental toxicity) Sub-chronic toxicity study (90-day): oral	13/12/2010 13/12/2010	27/01/2011 27/01/2011	Details
Reaction mass of Poly(oxy-1,2-ethanediyl), ?-[2-[(2-hydroxyethyl)amino]-2-oxoethyl]-?-hydroxy-, mono-C13-15-alkyl ethers (odd numbered, branched and linear)-alkylethers, Acetamide, 2-(C13-15 (odd numbered, branched and linear)-alkyloxy)-N-(2-hydroxyethyl)- and Alcohols, C13-15-branched and linear	-	-	Reproductive toxicity (pre-natal developmental toxicity)	16/08/2011	30/09/2011	Details
Reaction product of Distillates (petroleum), acid-treated heavy naphthenic and calcium oxide	-	-	Reproductive toxicity (pre-natal developmental toxicity)	16/08/2011	30/09/2011	Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid	-	-	Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011 16/08/2011 16/08/2011	30/09/2011 30/09/2011 30/09/2011 30/09/2011	Details
Reaction products of anilinohydroxypolycyclicsulphonic acid coupled twice with diazotised aminonitrophenol, complexes with [3-hydroxy-4-[(2-hydroxy-1-polycyclic)azo]-7-nitropolycyclic-1-sulphonato(3-)]chromium, sodium salts	-	-	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
Reaction products of Isophorone diamine, Butyl glycidyl ether, and Bisphenol A diglicydyl ether	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	22/06/2017 22/06/2017	07/08/2017 07/08/2017	Details
Silsesquioxanes, phenyl	-	70131-69-0	Long-term toxicity to fish	18/09/2014	03/11/2014	Details
terpenic oligomers	-	-	Reproductive toxicity (pre-natal developmental toxicity)	26/10/2022	12/12/2022	Details
Tris({[(hydroxyalkyl)amino]oxy}-oxoalkyl)-triazaalkanoic acid and water	-	-	Reproductive toxicity (pre-natal developmental toxicity)	12/06/2013	29/07/2013	Details
3,3'-iminodi(propylamine)	200-261-2	56-18-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
benzyltrimethylammonium chloride	200-300-3	56-93-9	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2014	17/03/2014	Details
Edetic acid	200-449-4	60-00-4	Sub-chronic toxicity (90 day): inhalation \|\| Note: testing proposed with_Na2H2EDTA (identifier not available)	16/06/2011	01/08/2011	Details
2-phenylethanol	200-456-2	60-12-8	Reproductive toxicity (two-generation reproductive toxicity)	15/04/2014	30/05/2014	Details
2-mercaptoethanol	200-464-6	60-24-2	Reproductive toxicity (pre-natal developmental toxicity)	15/04/2011	30/05/2011	Details
Diethyl ether	200-467-2	60-29-7	Reproductive toxicity (extended one-generation reproductive toxicity study)	02/11/2018	17/12/2018	Details
diethyl ether	200-467-2	60-29-7	Reproductive toxicity (two-generation reproductive toxicity)	15/07/2011	29/08/2011	Details
Androst-4-ene-3,17-dione	200-554-5	63-05-8	Long-term toxicity to fish	21/01/2021	08/03/2021	Details
Tetrasodium ethylenediaminetetraacetate	200-573-9	64-02-8	Sub-chronic toxicity (90 day): inhalation	16/06/2011	01/08/2011	Details
Hexanal	200-624-5	66-25-1	Genetic toxicity in vivo “\|\| Note: Testing proposal is based on concern identified by the registrant.”	27/05/2019	11/07/2019	Details
Dimethyl sulfoxide	200-664-3	67-68-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	31/01/2023	17/03/2023	Details
Mercaptoacetic acid	200-677-4	68-11-1	Long-term toxicity to fish	31/01/2023	17/03/2023	Details
cobalt di(acetate)	200-755-8	71-48-7	Carcinogenicity \|\| Note: testing proposed with Cobalt dichloride (EC 231-589-4) \|\| Note: Testing proposal is based on concern identified by the registrant Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant.	21/09/2020 21/09/2020	05/11/2020 05/11/2020	Details
Cobalt(II) diacetate	200-755-8	71-48-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/09/2011 02/09/2011 02/09/2011	17/10/2011 17/10/2011 17/10/2011	Details
N,N'-diphenyl-p-phenylenediamine	200-806-4	74-31-7	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant.	27/01/2020 27/01/2020	12/03/2020 12/03/2020	Details
Ethylene	200-815-3	74-85-1	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	30/09/2021 30/09/2021	15/11/2021 15/11/2021	Details
Methylamine	200-820-0	74-89-5	Genetic toxicity in vivo	14/02/2011	31/03/2011	Details
Chloroethane	200-830-5	75-00-3	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	10/03/2017 10/03/2017	25/04/2017 25/04/2017	Details
2-chloropropane	200-858-8	75-29-6	Reproductive toxicity (two-generation reproductive toxicity)	16/05/2011	30/06/2011	Details
2-chloropropane	200-858-8	75-29-6	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/03/2018	11/05/2018	Details
Nitromethane	200-876-6	75-52-5	Reproductive toxicity (pre-natal developmental toxicity)	04/04/2014	19/05/2014	Details
Tetramethylammonium chloride	200-880-8	75-57-0	Sub-chronic toxicity (90-day): oral	29/04/2014	13/06/2014	Details
Tetramethylammonium hydroxide	200-882-9	75-59-2	Sub-chronic toxicity (90-day): oral // Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8) \|\| Note: Link to justification in the registration dossier not given as the information is confidential	27/01/2020	12/03/2020	Details
Tetramethylammonium hydroxide	200-882-9	75-59-2	Long-term toxicity to fish	30/06/2023	14/08/2023	Details
2-methylpropane-2-thiol	200-890-2	75-66-1	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with tert-dodecanethiol (EC no. 246-619-1 ) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with tert-dodecanethiol (EC no. 246-619-1)	22/09/2022 22/09/2022	07/11/2022 07/11/2022	Details
Pivalic acid	200-922-5	75-98-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	20/12/2017 20/12/2017 20/12/2017	05/02/2018 05/02/2018 05/02/2018	Details
Trichloroacetic acid	200-927-2	76-03-9	Reproductive toxicity (two-generation reproductive toxicity)	16/06/2011	01/08/2011	Details
Trichloroacetic acid	200-927-2	76-03-9	Reproductive toxicity (pre-natal developmental toxicity)	14/10/2011	28/11/2011	Details
Perfluoroethane	200-939-8	76-16-4	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation	14/08/2014 14/08/2014 14/08/2014	28/09/2014 28/09/2014 28/09/2014	Details
3a,4,7,7a-tetrahydro-4,7-methanoindene	201-052-9	77-73-6	Reproductive toxicity (pre-natal developmental toxicity)	28/02/2019	15/04/2019	Details
Trometamol	201-064-4	77-86-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with 2-amino-1,3-propanediol Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 2-amino-1,3-propanediol	17/06/2014 17/06/2014	01/08/2014 01/08/2014	Details
tetraethylammonium hydroxide	201-073-3	77-98-5	Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with N,N,N-trimethylmethanaminium chloride (EC 200-880-8; CAS 75-57-0)	30/09/2015	16/11/2015	Details
Propylidynetrimethanol	201-074-9	77-99-6	Reproductive toxicity (pre-natal developmental toxicity)	16/05/2011	30/06/2011	Details
Propylidynetrimethanol	201-074-9	77-99-6	Reproductive toxicity (pre-natal developmental toxicity) // Note: testing proposed on rabbits	16/05/2014	30/06/2014	Details
Tetraethyllead	201-075-4	78-00-2	Sub-chronic toxicity study (90-day)	01/07/2011	15/08/2011	Details
Triethoxy(vinyl)silane	201-081-7	78-08-0	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with trimethoxy(vinyl)silane (EC 220-449-8) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with trimethoxy(vinyl)silane (EC 220-449-8)	23/04/2018 23/04/2018	07/06/2018 07/06/2018	Details
1-ethynylcyclohexanol	201-100-9	78-27-3	Sub-chronic toxicity (90-day): oral	18/02/2014	04/04/2014	Details
Diethyl ethylphosphonate	201-111-9	78-38-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	27/01/2020 27/01/2020	12/03/2020 12/03/2020	Details
tris(2-butoxyethyl) phosphate	201-122-9	78-51-3	Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011	15/08/2011	Details
Tris(2-butoxyethyl) phosphate	201-122-9	78-51-3	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/03/2018 26/03/2018	11/05/2018 11/05/2018	Details
di-tert-butyl 1,1,4,4-tetramethyltetramethylene diperoxide	201-128-1	78-63-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/10/2011 14/10/2011	28/11/2011 28/11/2011	Details
2,2'-dimethyl-2,2'-azodipropiononitrile	201-132-3	78-67-1	Reproductive toxicity (pre-natal developmental toxicity)	03/02/2016	21/03/2016	Details
2,2'-dimethyl-2,2'-azodipropiononitrile	201-132-3	78-67-1	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/03/2011 15/03/2011 15/03/2011	29/04/2011 29/04/2011 29/04/2011	Details
Linalool	201-134-4	78-70-6	Reproductive toxicity (pre-natal developmental toxicity)	01/07/2021	16/08/2021	Details
2-methylpropan-1-ol	201-148-0	78-83-1	Long-term toxicity to fish \|\|Note: testing proposed with Propan-1-ol (EC no. 200-746-9) \|\|Note: testing proposed with Pentan-1-ol (EC no. 200-752-1)	26/10/2022	12/12/2022	Details
Propylenediamine	201-155-9	78-90-0	Reproductive toxicity (pre-natal developmental toxicity)	16/12/2020	01/02/2021	Details
1-aminopropan-2-ol	201-162-7	78-96-6	Reproductive toxicity (pre-natal developmental toxicity)	17/09/2019	01/11/2019	Details
Chloroacetic acid	201-178-4	79-11-8	Reproductive toxicity (two-generation reproductive toxicity)	16/06/2011	01/08/2011	Details
Chloroacetic acid	201-178-4	79-11-8	Reproductive toxicity (pre-natal developmental toxicity)	14/10/2011	28/11/2011	Details
Peracetic acid	201-186-8	79-21-0	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/08/2021 26/08/2021	11/10/2021 11/10/2021	Details
Nitroethane	201-188-9	79-24-3	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with nitromethane (EC 200-876-6)	10/03/2017	25/04/2017	Details
2,5-di-tert-pentylhydroquinone	201-222-2	79-74-3	Sub-chronic toxicity (90-day): oral	31/05/2011	15/07/2011	Details
Camphene	201-234-8	79-92-5	Sub-chronic toxicity (90-day): oral	24/02/2020	09/04/2020	Details
4,4'-isopropylidenedi-o-cresol	201-240-0	79-97-0	Genetic toxicity in vivo	25/05/2020	09/07/2020	Details
4,4'-isopropylidenedicyclohexanol	201-244-2	80-04-6	Long-term toxicity to fish	17/06/2014	01/08/2014	Details
4,4'-isopropylidenedicyclohexanol	201-244-2	80-04-6	Genetic toxicity in vivo	16/12/2020	01/02/2021	Details
4,4'-isopropylidenedicyclohexanol	201-244-2	80-04-6	Reproductive toxicity (pre-natal developmental toxicity)	06/09/2018	22/10/2018	Details
bis(4-chlorophenyl) sulphone	201-247-9	80-07-9	Bioaccumulation: terrestrial Reproductive toxicity (pre-natal developmental toxicity)	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
Bis(4-chlorophenyl) sulphone	201-247-9	80-07-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	28/02/2018	16/04/2018	Details
4,4'-sulfonyldiphenol	201-250-5	80-09-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
4,4'-sulphonyldiphenol	201-250-5	80-09-1	Long-term toxicity to fish	16/06/2022	01/08/2022	Details
dichloro(diphenyl)silane	201-251-0	80-10-4	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9) Sub-chronic toxicity (90-day): oral Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9)	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
Bis(α,α-dimethylbenzyl) peroxide	201-279-3	80-43-3	Reproductive toxicity (pre-natal developmental toxicity	20/10/2016	05/12/2016	Details
bis(α,α-dimethylbenzyl) peroxide	201-279-3	80-43-3	Reproductive toxicity (extended one-generation reproductive toxicity study)	16/12/2020	01/02/2021	Details
bis(α,α-dimethylbenzyl) peroxide	201-279-3	80-43-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/06/2011 16/06/2011	01/08/2011 01/08/2011	Details
bis(α,α-dimethylbenzyl) peroxide	201-279-3	80-43-3	Reproductive toxicity (extended one-generation reproductive toxicity study)	10/05/2022	27/06/2022	Details
4,4'-oxydi(benzenesulphonohydrazide)	201-286-1	80-51-3	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/03/2014 21/03/2014 21/03/2014	05/05/2014 05/05/2014 05/05/2014	Details
1,3-dimethylimidazolidin-2-one	201-304-8	80-73-9	Reproductive toxicity (two-generation reproductive toxicity)	15/04/2014	30/05/2014	Details
1,3-dimethylimidazolidin-2-one	201-304-8	80-73-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
N-(4-amino-9,10-dihydro-3-methoxy-9,10-dioxo-1-anthryl)-4-methylbenzenesulphonamide	201-369-2	81-68-5	Genetic toxicity in vivo	20/05/2021	05/07/2021	Details
6,15-dihydroanthrazine-5,9,14,18-tetrone	201-375-5	81-77-6	Reproductive toxicity (pre-natal developmental toxicity)	14/08/2014	28/09/2014	Details
2-ethylanthraquinone	201-535-4	84-51-5	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity)	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
Phthalic anhydride	201-607-5	85-44-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	18/03/2021 18/03/2021	03/05/2021 03/05/2021	Details
1,3-diethyldiphenylurea	201-645-2	85-98-3	Sub-chronic toxicity (90-day): oral	03/03/2014	17/04/2014	Details
2-tert-butylphenol	201-807-2	88-18-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
Phthalic acid	201-873-2	88-99-3	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with phthalic anhydride (EC no. 201-607-5) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with phthalic anhydride (EC no. 201-607-5)	21/12/2021 21/12/2021	04/02/2022 04/02/2022	Details
Menthol	201-939-0	89-78-1	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/09/2017	16/10/2017	Details
Thymol	201-944-8	89-83-8	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)	16/06/2022 16/06/2022	01/08/2022 01/08/2022	Details
Decahydronaphthalene	202-046-9	91-17-8	Reproductive toxicity (extended one-generation reproductive toxicity study)	23/04/2018	07/06/2018	Details
decahydronaphthalene	202-046-9	91-17-8	Reproductive toxicity (two-generation reproductive toxicity)	15/07/2011	29/08/2011	Details
6-phenyl-1,3,5-triazine-2,4-diamine	202-095-6	91-76-9	Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (pre-natal developmental toxicity)	12/06/2013	29/07/2013	Details
Biphenyl	202-163-5	92-52-4	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2018	19/03/2018	Details
Biphenyl-4,4'-diol	202-200-5	92-88-6	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/04/2019 26/04/2019	10/06/2019 10/06/2019	Details
Biphenyl-4,4'-diol	202-200-5	92-88-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
2-(2-naphthyloxy)ethanol	202-228-8	93-20-9	Genetic toxicity in vivo	16/05/2014	30/06/2014	Details
Methyl benzoate	202-259-7	93-58-3	6.1.2 Long-term toxicity to fish	08/03/2024	22/04/2024	Details
Vinyl 2-ethylhexanoate	202-297-4	94-04-2	Reproductive toxicity (two-generation reproductive toxicity)	14/10/2011	28/11/2011	Details
Vinyl 2-ethylhexanoate	202-297-4	94-04-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/10/2022	12/12/2022	Details
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate)	202-319-2	94-28-0	Reproductive toxicity (pre-natal developmental toxicity)	01/07/2021	16/08/2021	Details
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate)	202-319-2	94-28-0	Sub-chronic toxicity (90-day): oral	26/01/2011	14/03/2011	Details
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate)	202-319-2	94-28-0	Reproductive toxicity (two-generation reproductive toxicity)	18/09/2014	03/11/2014	Details
Dibenzoyl peroxide	202-327-6	94-36-0	Reproductive toxicity (pre-natal developmental toxicity)	16/06/2011	01/08/2011	Details
Dibenzoyl peroxide	202-327-6	94-36-0	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020 16/12/2020	01/02/2021 01/02/2021 01/02/2021	Details
Ethylene dibenzoate	202-338-6	94-49-5	Developmental neurotoxicity Reproductive toxicity (pre-natal developmental toxicity	21/05/2018 21/05/2018	05/07/2018 05/07/2018	Details
Dimethyl cyclohexane-1,4-dicarboxylate	202-347-5	94-60-0	Reproductive toxicity (pre-natal developmental toxicity)	15/04/2014	30/05/2014	Details
Benzotriazole	202-394-1	95-14-7	Reproductive toxicity (pre-natal developmental toxicity)	22/10/2013	05/12/2013	Details
o-xylene	202-422-2	95-47-6	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with p-xylene (EC 203-396-5)	22/04/2021	07/06/2021	Details
o-cresol	202-423-8	95-48-7	Long-term toxicity to fish\|\|Note: testing proposed with p-cresol (EC no. 203-398-6)	10/05/2022	27/06/2022	Details
1,2,4-trimethylbenzene	202-436-9	95-63-6	Reproductive toxicity (pre-natal developmental toxicity)	03/10/2023	17/11/2023	Details
Pentan-3-one	202-490-3	96-22-0	Reproductive toxicity (two-generation reproductive toxicity)	15/07/2011	29/08/2011	Details
methyl acrylate; methyl propenoate	202-500-6	96-33-3	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
Imidazolidine-2-thione	202-506-9	96-45-7	Long-term toxicity to fish	29/04/2011	14/06/2011	Details
tetrahydro-2-methylfuran	202-507-4	96-47-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	27/01/2020 27/01/2020	12/03/2020 12/03/2020	Details
tetrahydro-2-methylfuran	202-507-4	96-47-9	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	23/01/2015 23/01/2015	09/03/2015 09/03/2015	Details
2,4-di-tert-butylphenol	202-532-0	96-76-4	Sub-chronic toxicity (90-day): oral	16/05/2011	30/06/2011	Details
5-sulphosalicylic acid	202-555-6	97-05-2	Genetic toxicity in vivo	10/05/2022	27/06/2022	Details
Itaconic acid	202-599-6	-	Reproductive toxicity (two-generation reproductive toxicity)	16/01/2012	01/03/2012	Details
Ethylene dimethacrylate	202-617-2	97-90-5	Sub-chronic toxicity (90-day): oral	03/10/2023	17/11/2023	Details
4-tert-butylpyrocatechol	202-653-9	98-29-3	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)	28/02/2018 28/02/2018	16/04/2018 16/04/2018	Details
4-tert-butylpyrocatechol	202-653-9	98-29-3	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	29/04/2011 29/04/2011 29/04/2011	14/06/2011 14/06/2011 14/06/2011	Details
Cyclohexyldimethylamine	202-715-5	98-94-2	Reproductive toxicity (pre-natal developmental toxicity)	01/07/2021	16/08/2021	Details
1,3-diisopropylbenzene	202-773-1	99-62-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
1-isopropyl-4-methylcyclohexane	202-790-4	99-82-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
4'-hydroxyacetophenone	202-802-8	99-93-4	Reproductive toxicity (pre-natal developmental toxicity)	25/10/2017	11/12/2017	Details
1,4-diisopropylbenzene	202-826-9	100-18-5	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with CAS no. 99-62-7 Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with CAS no. 99-62-7	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
Terephthalic acid	202-830-0	100-21-0	Reproductive toxicity (pre-natal developmental toxicity)	16/12/2020	01/02/2021	Details
Ethylbenzene	202-849-4	100-41-4	6.1.2 Long-term toxicity to fish	08/03/2024	22/04/2024	Details
Styrene	202-851-5	100-42-5	Long-term toxicity to fish	04/09/2023	19/10/2023	Details
Styrene	202-851-5	100-42-5	Long-term toxicity to fish	30/06/2023	14/08/2023	Details
N-methylaniline	202-870-9	100-61-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90 day): dermal	23/04/2018 23/04/2018	07/06/2018 07/06/2018	Details
N-methylaniline	202-870-9	100-61-8	Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): dermal	01/07/2011 01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011 15/08/2011	Details
Anisole	202-876-1	100-66-3	Reproductive toxicity (pre-natal developmental toxicity)	15/04/2014	30/05/2014	Details
2,2-dimethyl-1,3-dioxolan-4-ylmethanol	202-888-7	100-79-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	17/04/2015 17/04/2015	04/06/2015 04/06/2015	Details
2,2-dimethyl-1,3-dioxolan-4-ylmethanol	202-888-7	100-79-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	25/05/2020 25/05/2020	09/07/2020 09/07/2020	Details
2,4,6-triallyloxy-1,3,5-triazine	202-936-7	101-37-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): oral	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
4,4'-methylenediphenyl diisocyanate	202-966-0	101-68-8	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/11/2021	10/01/2022	Details
Dicyclohexylamine	202-980-7	101-83-7	Genetic toxicity in vivo (mammalian bone marrow chromosome aberration test) Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/03/2011 15/03/2011 15/03/2011 15/03/2011	29/04/2011 29/04/2011 29/04/2011 29/04/2011	Details
1,3-diphenylguanidine	203-002-1	102-06-7	Long-term toxicity to fish	15/04/2011	30/05/2011	Details
1,3-diphenyl-2-thiourea	203-004-2	102-08-9	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
2-dibutylaminoethanol	203-057-1	102-81-8	Genetic toxicity in vivo	21/03/2014	05/05/2014	Details
2-ethylhexyl acrylate	203-080-7	103-11-7	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
Bis(2-ethylhexyl) adipate	203-090-1	103-23-1	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study)	01/04/2022 01/04/2022	16/05/2022 16/05/2022	Details
di(morpholin-4-yl) disulphide	203-103-0	103-34-4	Long-term toxicity to fish Sub-chronic toxicity (90-day): oral	29/04/2011 29/04/2011	14/06/2011 14/06/2011	Details
Benzyldimethylamine	203-149-1	103-83-3	Reproductive toxicity (pre-natal developmental toxicity)	15/09/2011	31/10/2011	Details
Benzyldimethylamine	203-149-1	103-83-3	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	23/03/2020 23/03/2020 23/03/2020	07/05/2020 07/05/2020 07/05/2020	Details
Benzyldimethylamine	203-149-1	103-83-3	Long-term toxicity to fish	06/06/2023	21/07/2023	Details
Benzyldimethylamine	203-149-1	103-83-3	6.1.2 Long-term toxicity to fish	08/03/2024	22/04/2024	Details
2,2'-p-phenylenedioxydiethanol	203-197-3	104-38-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
3-aminopropyldiethylamine	203-236-4	104-78-9	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/03/2014 21/03/2014	05/05/2014 05/05/2014	Details
Cyclohexane-1,4-diyldimethanol	203-268-9	105-08-8	OECD Guideline 414 (Prenatal Developmental Toxicity Study)	19/11/2010	03/01/2011	Details
Diethyl carbonate	203-311-1	105-58-8	Genetic toxicity in vivo	18/02/2014	04/04/2014	Details
Bisisopropyl peroxydicarbonate	203-317-4	105-64-6	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	24/08/2020	08/10/2020	Details
Dilauroyl peroxide	203-326-3	105-74-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/04/2011 29/04/2011	14/06/2011 14/06/2011	Details
Dibutyl fumarate	203-327-9	105-75-9	Long-term toxicity to fish	16/05/2011	30/06/2011	Details
Citronellyl formate	203-338-9	105-85-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant	17/06/2020	03/08/2020	Details
12-hydroxystearic acid	203-366-1	106-14-9	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023 03/10/2023 03/10/2023	17/11/2023 17/11/2023 17/11/2023 17/11/2023	Details
3,7-dimethyloctan-1-ol	203-374-5	106-21-8	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2014	17/03/2014	Details
Geraniol	203-377-1	106-24-1	Reproductive toxicity (pre-natal developmental toxicity)	15/07/2022	29/08/2022	Details
Geraniol	203-377-1	106-24-1	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/10/2017	11/12/2017	Details
Geraniol	203-377-1	106-24-1	Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011	15/08/2011	Details
Nerol	203-378-7	106-25-2	Reproductive toxicity (pre-natal developmental toxicity)	14/08/2014	28/09/2014	Details
p-xylene	203-396-5	106-42-3	Reproductive toxicity (extended one-generation reproductive toxicity study)	18/02/2021	05/04/2021	Details
p-cresol	203-398-6	106-44-5	Long-term toxicity to fish	10/05/2022	27/06/2022	Details
p-phenylenediammine	203-404-7	106-50-3	Long-term toxicity testing to fish	26/01/2011	14/03/2011	Details
1,4-dimethylpiperazine	203-412-0	106-58-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/05/2020 25/05/2020	09/07/2020 09/07/2020	Details
Dimethyl sebacate	203-431-4	106-79-6	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	31/01/2014 31/01/2014 31/01/2014	17/03/2014 17/03/2014 17/03/2014	Details
1-bromopropane (n-propyl bromide)	203-445-0	106-94-5	Genetic toxicity in vivo	15/04/2011	30/05/2011	Details
But-1-ene	203-449-2	106-98-9	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: substance belongs to a category and testing is proposed with 2-methylpropene (EC 204-066-3) and Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: substance belongs to a category and testing is proposed with 2-methylpropene (EC 204-066-3) and Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1) Sub-chronic toxicity (90 day): inhalation \|\| Note: substance belongs to a category and testing is proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC 306-004-1)	16/12/2020 16/12/2020 16/12/2020	01/02/2021 01/02/2021 01/02/2021	Details
But-1-ene	203-449-2	106-98-9	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Sub-chronic toxicity (90 day): inhalation\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3)	06/06/2023 06/06/2023 06/06/2023	21/07/2023 21/07/2023 21/07/2023	Details

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