Προηγούμενες/Αποτελέσματα
Προηγούμενες/Αποτελέσματα
Προηγούμενες/Αποτελέσματα
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
N,N,N`,N`,N``-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride | 629-716-7 | 1211950-04-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
N,N,N',N'-tetramethylhexamethylenediamine | 203-842-9 | 111-18-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
N,N,N',N'-tetramethyl-2,2'-oxybis(ethylamine) | 221-220-5 | 3033-62-3 |
7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity |
08/03/2024 08/03/2024 |
22/04/2024 22/04/2024 |
Details | |
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine | 264-438-6 | 63738-22-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine | 695-748-3 | 65286-55-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
N,N'-hexane-1,6-diylbis(hexahydro-2-oxo-1H-azepine-1-carboxamide) | 227-563-7 | 5888-87-9 | Genetic toxicity in vivo | 18/09/2014 | 03/11/2014 | Details | |
N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) | 204-613-6 | 123-26-2 |
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with: “Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine”, CAS 100545-48-0 Sub-chronic toxicity (90 day): oral |
30/09/2015 30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 16/11/2015 |
Details | |
N,N'-diphenyl-p-phenylenediamine | 200-806-4 | 74-31-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
N,N'-dimethyldiphenylthiuram disulphide | 234-196-6 | 10591-84-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
N,N'-bis(3-aminopropyl)ethylenediamine | 234-147-9 | 10563-26-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/03/2021 18/03/2021 |
03/05/2021 03/05/2021 |
Details | |
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide | 419-710-0 | - |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
12/12/2014 12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 26/01/2015 |
Details | |
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] | 258-981-8 | 54112-23-1 |
Long-term toxicity to fish Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. |
31/08/2015 | 15/10/2015 | Details | |
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] | 258-981-8 | 54112-23-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
N,N''-propane-1,3-diylbis[N'-octadecylurea | 252-667-4 | 35674-65-8 | Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) | 29/03/2016 | 13/05/2016 | Details | |
N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea] | 241-523-6 | 17526-94-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine | 229-761-9 | 6711-48-4 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with N,N-diethylpropane-1,3-diamine (EC no. 203-236-4) | 22/09/2022 | 07/11/2022 | Details | |
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide | 435-860-1 | 214417-91-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/05/2020 25/05/2020 |
09/07/2020 09/07/2020 |
Details | |
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide | 435-860-1 | 214417-91-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2012 17/04/2012 |
01/06/2012 01/06/2012 |
Details | |
Multi-Wall Carbon Nanotubes, synthetic graphite in tubular shape | 231-955-3 | 7782-42-5 | Long-term toxicity to fish | 03/11/2011 | 19/12/2011 | Details | |
Morpholine, 4-C12-14-alkyl derivs. | 800-906-3 | 1402434-48-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Mono- and/or di- and/or tri(1-phenylethyl)-m-cresol and p-cresol | 700-427-9 | - |
Reproductive toxicity (developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
01/12/2010 01/12/2010 01/12/2010 |
17/01/2011 17/01/2011 17/01/2011 |
Details | |
Middle distillate from refinery proces cofeeding vegetable oil | 938-793-9 | - | Reproductive toxicity (two-generation reproductive toxicity) | 02/09/2013 | 18/10/2013 | Details | |
methylsilanetriyl triacetate | 224-221-9 | 4253-34-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [Trimethoxy(methyl)silane] (EC 214-685-0) | 16/03/2015 | 30/04/2015 | Details | |
methylsilanetriyl triacetate | 224-221-9 | 4253-34-3 | Sub-chronic toxicity (90-day): oral||Note: testing proposed with [triethoxy(methyl)silane] (CAS no. 2031-67-6) | 03/10/2023 | 17/11/2023 | Details | |
Methylphosphonic acid | 213-607-2 | 993-13-5 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
Methylene-bis-4,1-(N-phenylene-N'-butylurea) | 416-600-4 | - | Bioaccumulation aquatic / sediment | 17/05/2016 | 01/07/2016 | Details | |
Methylamine | 200-820-0 | 74-89-5 | Genetic toxicity in vivo | 14/02/2011 | 31/03/2011 | Details | |
methyl-1h-benzotriazole | 249-596-6 | 29385-43-1 | Sub-chronic toxicity (90-day): oral | 16/12/2020 | 01/02/2021 | Details | |
methyl-1h-benzotriazole | 249-596-6 | 29385-43-1 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with either Benzotriazole, Tolyltriazole, Sodium Benzotriazolate, or Sodium Tolyltriazolate | 16/12/2016 | 30/01/2017 | Details | |
Methyl trimethyl-3-[(1-oxododecyl)amino]propylammonium sulphate | 234-204-8 | 10595-49-0 | Reproductive toxicity (pre-natal developmental toxicity) | 16/12/2020 | 01/02/2021 | Details | |
Methyl isothiocyanate | 209-132-5 | 556-61-6 | Genetic toxicity in vivo | 17/11/2011 | 02/01/2012 | Details | |
Methyl benzoylformate | 239-263-3 | 15206-55-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 |
Details | |
Methyl benzoate | 202-259-7 | 93-58-3 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
methyl acrylate; methyl propenoate | 202-500-6 | 96-33-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
Methyl [3-(trimethoxysilyl)propyl]carbamate | 245-659-7 | 23432-62-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/03/2017 10/03/2017 10/03/2017 |
25/04/2017 25/04/2017 25/04/2017 |
Details | |
Methyl 4-[[(2,5-dichlorophenyl)amino]carbonyl]-2-[[2-hydroxy-3-[[(2-methoxyphenyl)amino]carbonyl]-1-naphthyl]azo]benzoate – bulk and nano forms | 263-272-1 | 61847-48-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 03/10/2023 | 17/11/2023 | Details | |
Methanal, reaction products with 1,3-bis(aminomethyl)benzene and hydroxybenzen | 701-207-5 | 1950616-36-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/05/2018 21/05/2018 21/05/2018 |
05/07/2018 05/07/2018 05/07/2018 |
Details | |
Mercaptoacetic acid | 200-677-4 | 68-11-1 | Long-term toxicity to fish | 31/01/2023 | 17/03/2023 | Details | |
Mequinol | 205-769-8 | 150-76-5 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2011 | 14/06/2011 | Details | |
Menthol | 201-939-0 | 89-78-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/09/2017 | 16/10/2017 | Details | |
Melamine | 203-615-4 | 108-78-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/05/2016 | 01/07/2016 | Details | |
Manganese dioxide | 215-202-6 | 1313-13-9 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Manganese carbonate | 209-942-9 | 598-62-9 | Reproductive toxicity (pre-natal developmental toxicity) | 26/08/2021 | 11/10/2021 | Details | |
Maleic acid | 203-742-5 | 110-16-7 | Reproductive toxicity (pre-natal developmental toxicity) | 17/06/2020 | 03/08/2020 | Details | |
Magnesium, bis(2-hydroxybenzoato-O1,O2)-, ar,ar'-di-C14-18alkyl derivs | 931-371-5 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
Magnesium metaborate | 237-235-5 | 13703-82-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/11/2021 | 10/01/2022 | Details | |
m-xylene | 203-576-3 | 108-38-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with p-xylene (EC 203-396-5) | 18/02/2021 | 05/04/2021 | Details | |
m-phenylene di(acetate) | 203-596-2 | 108-58-7 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
m-cresol | 203-577-9 | 108-39-4 | Long-term toxicity to fish|| Note: testing proposed with p-cresol (EC no. 203-398-6) | 10/05/2022 | 27/06/2022 | Details | |
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 275-662-9 | 71604-74-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |