Προηγούμενες/Αποτελέσματα

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Εμφάνιση 1.201 - 1.300 από 2.011 αποτελέσματα.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts	272-238-5	68784-31-6	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts	272-238-5	68784-31-6	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with another ZDDP read-across category member depending on the outcome of the other testing proposals Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Distillates (petroleum), full-range straight-run middle	272-341-5	68814-87-9	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Distillates (petroleum), heavy straight-run (EC 272-817-2) (CAS 68915-96-8)	21/01/2021	08/03/2021	Details
Distillates (petroleum), full-range straight-run middle	272-341-5	68814-87-9	Reproductive toxicity (two-generation reproductive toxicity)	02/09/2011	17/10/2011	Details
Kieselguhr, soda ash flux-calcined	272-489-0	68855-54-9	Sub-chronic toxicity (90 day): inhalation	01/07/2011	15/08/2011	Details
Allyl (cyclohexyloxy)acetate	272-657-3	68901-15-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	10/08/2018 10/08/2018	24/09/2018 24/09/2018	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts	272-723-1	68909-93-3	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral \|\| Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts	272-723-1	68909-93-3	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides, reaction products with polyethylenepolyamines and tall-oil fatty acids, humates hydrochlorides	272-745-1	68910-55-4	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation	23/01/2015 23/01/2015 23/01/2015 23/01/2015	09/03/2015 09/03/2015 09/03/2015 09/03/2015	Details
Hydrocarbons, C12-30, olefin-rich, ethylene polymn. by-product	272-762-4	68911-05-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011 25/06/2012	30/09/2011 30/09/2011 09/08/2012	Details
Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine	272-789-1	68911-83-1	Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant.	15/07/2014	29/08/2014	Details
Distillates (petroleum), heavy straight-run	272-817-2	68915-96-8	Reproductive toxicity (two-generation reproductive toxicity)	02/09/2011	17/10/2011	Details
Gas oils (petroleum), straight-run, high-boiling	272-818-8	68915-97-9	Reproductive toxicity (two-generation reproductive toxicity)	02/09/2011	17/10/2011	Details
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol	272-902-4	68919-76-6	Reproductive toxicity (pre-natal developmental toxicity)	10/03/2017	25/04/2017	Details
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol	272-902-4	68919-76-6	Sub-chronic toxicity (90 day): oral	16/05/2014	30/06/2014	Details
Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene	272-940-1	68921-45-9	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with the smallest aryl- and alkyl-substituted materials Reproductive toxicity (two-generation reproductive toxicity) \|\| Note: testing proposed with the smallest aryl- and alkyl-substituted materials	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
Phenol, isopropylated, phosphate (3:1)	273-066-3	68937-41-7	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/03/2018	11/05/2018	Details
Phenol, isopropylated, phosphate (3:1)	273-066-3	68937-41-7	Bioaccumulation aquatic / sediment Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	29/07/2011 29/07/2011 29/07/2011 29/07/2011 29/07/2011	12/09/2011 12/09/2011 12/09/2011 12/09/2011 12/09/2011	Details
Phenol, isopropylated, phosphate (3:1)	273-066-3	68937-41-7	Reproductive toxicity (pre-natal developmental toxicity)	30/06/2023	14/08/2023	Details
Polysulfides, di-tert-Bu	273-103-3	68937-96-2	Bioaccumulation aquatic / sediment	01/07/2011	15/08/2011	Details
Octene, hydroformylation products, low-boiling	273-110-1	68938-03-4	Reproductive toxicity (pre-natal developmental toxicity)	23/11/2020	07/01/2021	Details
Octene, hydroformylation products, low-boiling	273-110-1	68938-03-4	Genetic toxicity in vivo	17/06/2014	01/08/2014	Details
Resin acids and Rosin acids, cobalt salts	273-321-9	68956-82-1	Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2)	21/01/2021	08/03/2021	Details
Resin acids and Rosin acids, cobalt salts	273-321-9	68956-82-1	Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Neodecanoic acid, cobalt salt (EC no. 248-373-0)	28/11/2022	12/01/2023	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts	273-527-9	68988-45-4	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"	04/10/2018 04/10/2018	19/11/2018 19/11/2018	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts	273-527-9	68988-45-4	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with a read-across member of the ZDDP category(identity of test material not yet decided) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Slags, ferromanganese-manufg.	273-728-1	69012-28-8	Reproductive toxicity (pre-natal developmental toxicity)	26/03/2018	11/05/2018	Details
Slags, phosphorus-manufg.	273-732-3	69012-32-4	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation	01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011	Details
Slags, silicomanganese-manufg.	273-733-9	69012-33-5	Reproductive toxicity (pre-natal developmental toxicity)\|\| Note: testing proposed with Slags, ferromanganese-manufg. CAS No 69012-28-8 (EC No 273-728-1)	25/10/2017	11/12/2017	Details
Disodium 1-amino-4-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate	274-397-6	70209-99-3	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
Disodium 5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxy-6-(methylamino)naphthalene-2-sulphonate	274-436-7	70210-39-8	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	19/10/2020	03/12/2020	Details
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate	274-437-2	70210-40-1	Genetic toxicity in vivo	18/02/2021	05/04/2021	Details
Disodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthyl)azo]-7-nitronaphthalene-1-sulphonato(3-)]chromate(2-)	274-490-1	70236-60-1	Genetic toxicity in vivo	21/10/2021	07/12/2021	Details
Disodium 4-[4-[[5-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-2,5-dichlorobenzenesulphonate	274-499-0	70247-70-0	Genetic toxicity in vivo	18/02/2021	05/04/2021	Details
2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol	274-570-6	70321-86-7	Bioaccumulation aquatic / sediment	15/07/2014	29/08/2014	Details
3-(benzothiazol-2-yl)-7-(diethylamino)-2-oxo-2H-1-benzopyran-4-carbonitrile	274-668-9	70546-25-7	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
[[(phosphonomethyl)imino]bis[ethylenenitrilobis(methylene)]]tetrakisphosphonic acid, ammonium salt	274-798-6	70714-66-8	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with Sodium salts of [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid (5-7 Na:1) (EC no. 701-216-4)	01/03/2023	17/04/2023	Details
O-(2-ethylhexyl) O,O-tert-pentyl peroxycarbonate	274-919-2	70833-40-8	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023 03/10/2023	17/11/2023 17/11/2023 17/11/2023	Details
O-(2-ethylhexyl) O,O-tert-pentyl peroxycarbonate	274-919-2	70833-40-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
Formaldehyde, reaction products with m-phenylenediamine, sodium sulfide (Na2S) and sulfur	274-986-8	70892-34-1	Genetic toxicity in vivo	15/01/2024	29/02/2024	Details
Phenol, 2-methoxy-, reaction products with 2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane, hydrogenated	275-062-7	70955-71-4	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/08/2021	11/10/2021	Details
Octasodium 2,2'-[1,4-phenylenebis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino(1-hydroxy-3,6-disulphonatonaphthalene-2,8-diyl)azo]]bisnaphthalene-1,5-disulphonate	275-108-6	71002-20-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant	16/12/2020	01/02/2021	Details
[1α(E),2β]-1-(2,6,6-trimethylcyclohex-3-en-1-yl)but-2-en-1-one	275-156-8	71048-82-3	Reproductive toxicity (pre-natal developmental toxicity)	26/10/2022	12/12/2022	Details
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline	275-662-9	71604-74-5	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014 29/08/2014	Details
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs.	276-014-8	71786-60-2	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): oral	14/08/2014 14/08/2014 14/08/2014	28/09/2014 28/09/2014 28/09/2014	Details
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs.	276-014-8	71786-60-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/06/2019	09/08/2019	Details
Quaternary ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl, chlorides	276-038-9	71808-53-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
6-[(1-oxomethyloctyl)amino]hexanoic acid	276-173-3	71902-23-3	Reproductive toxicity (pre-natal developmental toxicity)	10/03/2017	25/04/2017	Details
4,6-dichloro-N-(1,1,3,3-tetramethylbutyl)-1,3,5-triazin-2-amine	276-309-1	72058-41-4	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity)	23/11/2020 23/11/2020	07/01/2021 07/01/2021	Details
Iron, complexes with diazotized 5-amino-2-(phenylamino)benzenesulfonic acid monosodium salt coupled with 4-[(2-hydroxy-3,5-dinitrophenyl)azo]-1,3-benzenediol, diazotized 4-nitrobenzenamine and diazotized 3-aminobenzenesulfonic acid monosodium salt	276-464-5	72207-77-3	Genetic toxicity in vivo \|\| Note: testing proposed with Acid Brown 360 (EC 946-788-8)	20/05/2021	05/07/2021	Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione	276-763-0	72676-55-2	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	20/10/2016	05/12/2016	Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione	276-763-0	72676-55-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020	01/02/2021 01/02/2021	Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione	276-763-0	72676-55-2	Long-term toxicity to fish	30/06/2023	14/08/2023	Details
7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate	276-957-5	72869-86-4	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	19/10/2020	03/12/2020	Details
Disodium oxybis[methylbenzenesulphonate]	277-242-0	73037-34-0	Reproductive toxicity (pre-natal developmental toxicity)	17/06/2014	01/08/2014	Details
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide	278-355-8	75980-60-8	Reproductive toxicity (pre-natal developmental toxicity)	18/02/2014	04/04/2014	Details
Triisotridecyl phosphite	278-758-9	77745-66-5	Sub-chronic toxicity (90-day): oral	25/06/2019	09/08/2019	Details
N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine	278-817-9	78014-16-1	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/08/2021 26/08/2021 26/08/2021	11/10/2021 11/10/2021 11/10/2021	Details
Sulfonium compounds, C11-14-alkylbis(hydroxyethyl), 2-hydroxyethyl sulfates (salts)	278-855-6	78169-20-7	Reproductive toxicity (pre-natal developmental toxicity)	18/02/2014	04/04/2014	Details
Trisodium 4-amino-5-hydroxy-3-[[4-[[2-oxo-1-[(phenylamino)carbonyl]propyl]azo]phenyl]azo]-6-[(4-sulphonato-1-naphthyl)azo]naphthalene-2,7-disulphonate	279-093-7	79135-92-5	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	21/01/2021	08/03/2021	Details
Sodium 1-amino-4-[[3,5-bis[[(chloroacetyl)amino]methyl]-2,4,6-trimethylphenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate	279-365-5	80010-51-1	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates	279-632-6	80939-62-4	Sub-chronic toxicity (90-day): oral	23/11/2020	07/01/2021	Details
Bis(trimethoxysilylpropyl)amine	280-084-5	82985-35-1	Reproductive toxicity (pre-natal developmental toxicity Sub-chronic toxicity (90-day): oral	17/06/2020 17/06/2020	03/08/2020 03/08/2020	Details
Bis(2,4,4-trimethylpentyl)phosphinic acid	280-445-7	83411-71-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/04/2014 29/04/2014	13/06/2014 13/06/2014	Details
Bis(2,4,4-trimethylpentyl)phosphinic acid	280-445-7	83411-71-6	Sub-chronic toxicity (90-day): oral	18/03/2021	03/05/2021	Details
Benzoic acid, 2-hydroxy-, mono-C>13-alkyl derivs., calcium salts (2:1)	281-018-8	83846-43-9	Sub-chronic toxicity (90-day): oral	18/06/2018	02/08/2018	Details
Formaldehyde, reaction products with ethylenediamine	281-928-5	84066-92-2	Genetic toxicity in vivo	16/05/2014	30/06/2014	Details
4-(1,1-dimethylethyl)cyclohexyl acrylate	282-104-8	84100-23-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	23/03/2020 23/03/2020	07/05/2020 07/05/2020	Details
1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether	282-199-6	84144-79-6	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant.	18/03/2021	03/05/2021	Details
1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates	282-617-7	84281-74-3	Genetic toxicity in vivo	25/11/2021	10/01/2022	Details
Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate	282-810-6	84434-11-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/05/2014 16/05/2014	30/06/2014 30/06/2014	Details
2-Butenoic acid, 4-oxo-4-(tridecylamino)-, (Z)-, branched	283-219-6	84583-68-6	Sub-chronic toxicity (90-day): oral	12/04/2017	29/05/2017	Details
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts	283-392-8	84605-29-8	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) and another read-across member from ZDDP category Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts	283-392-8	84605-29-8	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
Star anise, Illicium verum, ext.	283-518-1	84650-59-9	Genetic toxicity in vivo	22/04/2021	07/06/2021	Details
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]	284-366-9	84852-53-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	24/02/2020	09/04/2020	Details
Phosphoric acid, mixed esters with Bu alc. and ethylene glycol	284-716-0	84962-20-9	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1	20/05/2015 20/05/2015	06/07/2015 06/07/2015	Details
Fatty acids, C16-18 and C18-unsatd., Et esters	285-206-0	85049-36-1	Long-term toxicity to fish	01/07/2011	15/08/2011	Details
2-ethylhexanoic acid, monoester with propane-1,2-diol	285-503-5	85114-00-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-[(4-methyl-3-sulphonatophenyl)sulphonyl]phenyl]azo]naphthalene-2-sulphonate	286-122-7	85187-33-3	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	18/02/2021	05/04/2021	Details
2-Butenedioic acid (Z)-, ester with 1,2-propanediol, compd. with 2-(dibutylamino)ethanol	286-304-6	85204-10-0	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014 02/06/2014 02/06/2014	17/07/2014 17/07/2014 17/07/2014 17/07/2014	Details
2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt	286-344-4	85209-91-2	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	16/10/2014 16/10/2014 16/10/2014	01/12/2014 01/12/2014 01/12/2014	Details
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins)	287-476-5	85535-84-8	Reproductive toxicity (two-generation reproductive toxicity)	29/07/2011	12/09/2011	Details
Alkenes, C10-13	287-479-1	85535-87-1	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	15/09/2011 15/09/2011	31/10/2011 31/10/2011	Details
Alcohols, C13-15-branched and linear	287-625-4	85566-16-1	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study)	31/01/2023 31/01/2023	17/03/2023 17/03/2023	Details
Alcohols, C13-15-branched and linear	287-625-4	85566-16-1	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Isotridecan-1-ol (EC 248-469-2)	16/12/2020	01/02/2021	Details
Alkenes, C10-14	288-213-7	85681-75-0	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/09/2011 15/09/2011 25/06/2012	31/10/2011 31/10/2011 09/08/2012	Details
Fatty acids, tall-oil, compds. with oleylamine	288-315-1	85711-55-3	Long-term toxicity to fish	04/04/2014	19/05/2014	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts	288-917-4	85940-28-9	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with a read-across member of the ZDDP category Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts	288-917-4	85940-28-9	"Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“ " Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters	290-754-9	90218-76-1	Sub-chronic toxicity (90-day): oral	29/07/2011	12/09/2011	Details
Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts	291-454-0	90411-76-0	Reproductive toxicity (pre-natal developmental toxicity)	30/11/2015	14/01/2016	Details
1,5-Pentanediamine, 2-methyl-, reaction products with 2-ethyl-1,4-butanediamine and glycidyl tolyl ether	291-813-1	90480-76-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	19/10/2020 19/10/2020	03/12/2020 03/12/2020	Details
Alkenes, C11-12, hydroformylation products, distn. Residues	292-427-6	90622-27-8	Reproductive toxicity (extended one-generation reproductive toxicity study)	28/02/2018	16/04/2018	Details
Alkenes, C11-12, hydroformylation products, distn. residues	292-427-6	90622-27-8	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/09/2011 15/09/2011 15/09/2011	31/10/2011 31/10/2011 31/10/2011	Details
Alkenes, C13-14, hydroformylation products, distn. Residues	292-429-7	90622-29-0	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/09/2011 15/09/2011 15/09/2011	31/10/2011 31/10/2011 31/10/2011	Details
Alkenes, C13-14, hydroformylation products, distn. residues	292-429-7	90622-29-0	Reproductive toxicity (extended one-generation reproductive toxicity study) “\|\| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6)	02/11/2018	17/12/2018	Details
Alkanes, C12-26-branched and linear	292-454-3	90622-53-0	Reproductive toxicity (two-generation reproductive toxicity)	15/09/2011	31/10/2011	Details
Amines, polyethylenepoly-, tetraethylenepentamine fraction	292-587-7	90640-66-7	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with TETA (CAS 90640-67-8) and HEPA (68121-73-7) Reproductive toxicity (pre-natal developmental toxicity )	31/01/2018 31/01/2018	19/03/2018 19/03/2018	Details
Amines, polyethylenepoly-, tetraethylenepentamine fraction	292-587-7	90640-66-7	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/11/2015	16/12/2015	Details

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