EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 03 Maio 2024. Database contains 4917 unique substances/entries.

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Exibindo 1 - 50 de 4.917 resultados.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU REACH: List of SVHC
Di-, tri- and tetrachlorotetradecane	950-299-5	-		PBT Persistent, Bioaccumulative and Toxic (article 57d) VPVB very Persistent and very Bioaccumulative (article 57e)	Details
Nonylphenol, ethoxylated (10-EO) (9016-45-9)	939-993-9	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP)	939-460-0	1471311-26-8		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP)	939-460-0	1471311-26-8		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Nonylphenol, ethoxylated (polymer)	938-618-6	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Zirconia Aluminosilicate Refractory Ceramic Fibres	936-037-2	-		C Carcinogenic (article 57a)	Details
proteases with the exception of those specified elsewhere in this Annex show/hide Proteinase, serine (Tritirachium album) EC / List no: 686-165-5 \| CAS no: 102925-54-2 Proteinase, Bacillus subtilis serine EC / List no: 266-557-9 \| CAS no: 67051-83-6 Aspergillin M EC / List no: - \| CAS no: 42615-60-1 Proteinase, Bacillus alkaline EC / List no: 232-972-9 \| CAS no: 9073-77-2 Proteinase, Aspergillus alkaline EC / List no: 232-977-6 \| CAS no: 9074-07-1 Proteinase, Aspergillus niger neutral EC / List no: 254-422-7 \| CAS no: 39346-39-9 Proteinase, microbial neutral EC / List no: 232-966-6 \| CAS no: 9068-59-1 Proteinase, Aspergillus oryzae neutral EC / List no: 232-990-7 \| CAS no: 9080-55-1 Proteinase, Serratia extracellular EC / List no: 253-457-5 \| CAS no: 37312-62-2 Proteinase, Agkistrodon serine EC / List no: 232-933-6 \| CAS no: 9046-56-4 Proteinase, Bacillus subtilis EC / List no: 257-520-8 \| CAS no: 51931-23-8 Proteinase, Aspergillus acid EC / List no: 232-796-2 \| CAS no: 9025-49-4 Proteinase, Mucor aspartic EC / List no: 232-975-5 \| CAS no: 9073-79-4 Proteinase, Staphylococcus aureus serine EC / List no: 259-611-8 \| CAS no: 55354-32-0 Proteinase, serine EC / List no: 253-431-3 \| CAS no: 37259-58-8 Myxobacteralphalyticproteinase EC / List no: - \| CAS no: 12585-31-8 Proteinase, Bacillus subtilis, sutilain EC / List no: 235-390-3 \| CAS no: 12211-28-8 Proteinase, Bothrops atrox serine EC / List no: 232-918-4 \| CAS no: 9039-61-6 Proteinase, Aspergillus neutral EC / List no: 278-588-5 \| CAS no: 77000-13-6 Proteinase, aspartic EC / List no: 278-856-1 \| CAS no: 78169-47-8 Proteinase, rhizopus acid EC / List no: 812-486-9 \| CAS no: 9074-09-3 Amylase, mixture with proteinase EC / List no: 685-079-5 \| CAS no: 9001-11-0 Proteinase, pancreatic EC / List no: 232-626-7 \| CAS no: 9001-72-3 Proteinase, Endothia aspartic EC / List no: 253-395-9 \| CAS no: 37205-60-0 Proteinase, Tritirachium album serine EC / List no: 254-457-8 \| CAS no: 39450-01-6 Proteinase, Myxobacter α-lytic EC / List no: 253-448-6 \| CAS no: 37288-76-9 Proteinase, microbial alkaline EC / List no: 256-863-0 \| CAS no: 50936-53-3 Proteinase, Bacillus neutral EC / List no: 278-547-1 \| CAS no: 76774-43-1 Proteinase, Aspergillus parasiticus neutral EC / List no: 254-418-5 \| CAS no: 39335-09-6 Proteinase, Bacillus polymyxa neutral EC / List no: 255-914-4 \| CAS no: 42613-33-2 Proteinase, bacterial E 30 serine EC / List no: - \| CAS no: 39369-34-1 Proteinase, microbial acid EC / List no: 256-862-5 \| CAS no: 50936-52-2 Proteinase, Myxobacter AL-1, II EC / List no: 276-716-4 \| CAS no: 72561-05-8 Amylase, mixed with proteinase, Bacillus cereus-fermented EC / List no: - \| CAS no: 68909-35-3 Proteinase, Bacillus licheniformis serine EC / List no: 279-361-3 \| CAS no: 79986-26-8 Proteinase, Bacillus subtilis metallo- EC / List no: 232-991-2 \| CAS no: 9080-56-2 Thrombin EC / List no: 232-648-7 \| CAS no: 9002-04-4 Amylase, mixed with proteinase, Bacillus thuringiensis-fermented EC / List no: - \| CAS no: 68909-36-4 Proteinase, Aspergillus melleus, semialkaline EC / List no: - \| CAS no: 76106-83-7 Bacillus megaterium protease fermentation product EC / List no: - \| CAS no: 68909-17-1 Proteinase, submandibular gland serine, A EC / List no: 279-893-6 \| CAS no: 82047-85-6 Proteinase, Streptomyces griseus EC / List no: 232-909-5 \| CAS no: 9036-06-0 Proteinase, oryzin EC / List no: 232-992-8 \| CAS no: 9081-30-5 Bacteria, complex with amylase and proteinase EC / List no: - \| CAS no: 68920-42-3 Proteinase, Bacillus alcalophilus serine EC / List no: 306-090-0 \| CAS no: 95979-76-3	934-013-6	39450-01-6	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1		Details
Nonylphenolpolyglycolether	932-998-7	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Nonylphenol, ethoxylated (15-EO)	931-756-8	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Nonylphenol, ethoxylated (10-EO)	931-755-2	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Nonylphenol, ethoxylated (8-EO)	931-754-7	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Nonylphenol, ethoxylated (6,5-EO)	931-753-1	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Reaction mass of 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate and 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate; reaction mass of DOTE and MOTE	915-270-3	-		R Toxic for reproduction (article 57c)	Details
(2RS)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol; mefentrifluconazole	822-682-6	1417782-03-6	Skin Sens. 1		Details
N-methoxy-N-[1-methyl-2-(2,4,6-trichlorophenyl)-ethyl]-3-(difluoromethyl)- 1-methylpyrazole-4-carboxamide; pydiflumetofen	817-852-1	1228284-64-7	Carc. 2; Repr. 2		Details
(RS)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; medetomidine	811-718-6	86347-14-0	Acute Tox. 2; STOT SE 3; STOT SE 1; STOT RE 1		Details
N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide; isoflucypram	811-438-4	1255734-28-1	Repr. 2; Acute Tox. 4; Skin Sens. 1B		Details
sulfoxaflor (ISO); [methyl(oxo) {1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-λ6-sulfanylidene]cyanamide	807-366-8	946578-00-3	Acute Tox. 4		Details
4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one; flupyradifurone	804-373-8	951659-40-8	Acute Tox. 4; STOT RE 2		Details
Tris(4-nonylphenyl, branched) phosphite show/hide Phenol, 4-nonyl-, phosphite (3:1) EC / List no: 608-492-4 \| CAS no: 3050-88-2 Tris(nonylphenyl) phosphite EC / List no: 247-759-6 \| CAS no: 26523-78-4 tris(4-nonylphenyl, branched) phosphite EC / List no: 701-028-2 \| CAS no: - Phenol, p-isononyl-, phosphite (3:1) EC / List no: - \| CAS no: 31631-13-7 Phenol, p-sec-nonyl-, phosphite EC / List no: - \| CAS no: 106599-06-8	799-976-5	-		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
Dioctyltin dilaurate, stannane, dioctyl-, bis(coco acyloxy) derivs., and any other stannane, dioctyl-, bis(fatty acyloxy) derivs. wherein C12 is the predominant carbon number of the fatty acyloxy moiety show/hide dioctyltin dilaurate; stannane, dioctyl-, bis(coco acyloxy) derivs. EC / List no: - \| CAS no: - Dioctyltin dilaurate EC / List no: 222-883-3 \| CAS no: 3648-18-8 Stannane, dioctyl-, bis(coco acyloxy) derivs. EC / List no: 293-901-5 \| CAS no: 91648-39-4	799-973-9	-		R Toxic for reproduction (article 57c)	Details
Phenol, alkylation products (mainly in para position) with C12-rich branched alkyl chains from oligomerisation, covering any individual isomers and/ or combinations thereof (PDDP) show/hide Phenol, 4-isododecyl- EC / List no: 608-055-8 \| CAS no: 27147-75-7 Phenol, (tetrapropenyl) derivatives EC / List no: 616-100-8 \| CAS no: 74499-35-7 Phenol, 4-dodecyl, branched EC / List no: 640-104-9 \| CAS no: 210555-94-5 Phenol, tetrapropylene- EC / List no: - \| CAS no: 57427-55-1 [No public or meaningful name is available] EC / List no: - \| CAS no: 27459-10-5 Phenol, dodecyl-, branched EC / List no: 310-154-3 \| CAS no: 121158-58-5	799-972-3	-		R Toxic for reproduction (article 57c) ENDE Endocrine disrupting properties (Article 57(f) - environment) END Endocrine disrupting properties (Article 57(f) - human health)	Details
Medium-chain chlorinated paraffins (MCCP) UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17 show/hide Alkanes, C14-17, chloro EC / List no: 287-477-0 \| CAS no: 85535-85-9 Tetradecane, chloro derivs. EC / List no: - \| CAS no: 198840-65-2 Alkanes, C14-16, chloro EC / List no: 701-376-5 \| CAS no: 1372804-76-6 di-, tri- and tetrachlorotetradecane EC / List no: 950-299-5 \| CAS no: -	799-971-8	-		PBT Persistent, Bioaccumulative and Toxic (article 57d) VPVB very Persistent and very Bioaccumulative (article 57e)	Details
2-(4-tert-Butylbenzyl)propionaldehyde and its individual stereoisomers show/hide (2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC / List no: - \| CAS no: 75166-31-3 (2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC / List no: - \| CAS no: 75166-30-2 2-(4-tert-butylbenzyl)propionaldehyde EC / List no: 201-289-8 \| CAS no: 80-54-6	799-970-2	-		R Toxic for reproduction (article 57c)	Details
Potassium perfluoroheptanoate	701-468-5	21049-36-5		R Toxic for reproduction (article 57c) PBT Persistent, Bioaccumulative and Toxic (article 57d) VPVB very Persistent and very Bioaccumulative (article 57e) HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	Details
metaflumizone (ISO); (E)-2-[2-(4-cyanophenyl)-1-(a,a,a -trifluoro-m-tolyl) ethylidene]-[4-(trifluoro-methoxy)phenyl]carbani-lohydrazide [2]	701-454-9	852403-68-0	Repr. 2; Lact.; STOT RE 2		Details
(3E)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one	701-394-3	1782069-81-1		END Endocrine disrupting properties (Article 57(f) - human health)	Details
Alkanes, C14-16, chloro	701-376-5	1372804-76-6		PBT Persistent, Bioaccumulative and Toxic (article 57d) VPVB very Persistent and very Bioaccumulative (article 57e)	Details
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts	701-271-4	-	Repr. 1B; Eye Irrit. 2		Details
(RS)-1-{1-ethyl-4-[4-mesyl-3-(2-methoxyethoxy)-o-toluoyl]pyrazol-5-yloxy} ethyl methyl carbonate; tolpyralate	701-225-3	1101132-67-5	Carc. 2; Repr. 2; STOT RE 2		Details
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid	701-162-1	-	Repr. 1B		Details
6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid	701-118-1	2156592-54-8	Repr. 1B; Eye Irrit. 2		Details
phenol, 3-dodecyl-, branched	701-107-1	1801269-77-1	Repr. 1B; Skin Corr. 1C; Eye Dam. 1		Details
phenol, 2-dodecyl-, branched	701-105-0	1801269-80-6	Repr. 1B; Skin Corr. 1C; Eye Dam. 1		Details
Oligomerisation and alkylation reaction products of 2-phenylpropene and phenol show/hide Phenol, methylstyrenated EC / List no: 270-966-8 \| CAS no: 68512-30-1	700-960-7	-		VPVB very Persistent and very Bioaccumulative (article 57e)	Details
Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate	700-242-3	62037-80-3		E Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment) HH Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)	Details
2-methyl-1,2-benzothiazol-3(2H)-one; [MBIT]	695-989-4	2527-66-4	Acute Tox. 4; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A		Details
(5-chloro-2-methoxy-4-methyl-3-pyridyl) (4,5,6-trimethoxy-o-tolyl)methanone; pyriofenone	692-456-8	688046-61-9	Carc. 2		Details
benzovindiflupyr (ISO); N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	691-719-4	1072957-71-1	Acute Tox. 3		Details
N-{2-[[1,1'-bi (cyclopropyl)]-2-yl] phenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide; sedaxane	688-331-2	874967-67-6	Carc. 2		Details
2-{2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethoxy}ethanol	687-833-9	1119449-38-5		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol	687-832-3	1119449-37-4		ENDE Endocrine disrupting properties (Article 57(f) - environment)	Details
di-L-para-menthene	686-814-2	34363-01-4	Skin Irrit. 2; Skin Sens. 1		Details
acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine	682-791-8	160430-64-8	Repr. 2; Acute Tox. 3		Details
tetracopper hexahydroxide sulphate hydrate	682-362-5	12527-76-3	Acute Tox. 4		Details
trinexapac-ethyl (ISO); ethyl 4-[cyclopropyl (hydroxy) methylene]-3,5-dioxocyclohexanecarboxylate	680-302-2	95266-40-3	STOT RE 2; Skin Sens. 1B		Details
diphenyl(4-phenylthiophenyl)sulfonium hexafluoroantimonate	680-227-5	71449-78-0	Skin Sens. 1		Details
amisulbrom (ISO); 3-(3-bromo-6-fluoro-2-methylindol-1-ylsulfonyl)-N,N-dimethyl-1H-1,2,4-triazole-1-sulfonamide	672-776-4	348635-87-0	Carc. 2; Eye Irrit. 2		Details
cyflumetofen (ISO); 2-methoxyethyl (RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate	642-974-5	400882-07-7	Carc. 2; Skin Sens. 1A		Details
hydroxyisohexyl 3-cyclohexene carboxaldehyde (INCI); reaction mass of 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde and 3-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde	641-410-5	130066-44-3	Skin Sens. 1A		Details

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EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

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Last updated 03 Maio 2024. Database contains 4917 unique substances/entries.

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