EU-PRODUCT_SAFETY-ART_2

General Product Safety Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of General Product Safety Directive (2001/95/EC), 15 January 2002, amended by Reg 596/2009/EC, 18 July 2009

This list contains a non-exhaustive inventory of substances that fall within the European Union's hazardous substance definitions, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; (2) Annex III of Directive 2000/54/EC (Biological Agents); Candidate List of SVHCs; and REACH Annexes XIV and XVII (Authorisation and Restriction lists). They can be considered hazardous for purposes of the General Product Safety Directive 2001/95/EC.

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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU REACH: Annex XIV
EU REACH: List of SVHC
EU REACH: Annex XVII
EU_BA Directive 2000/54/EC
o-toluidine; 2-aminotoluene
202-429-0
95-53-4
yes
yes
Annex 17 Appendix 2
o-tolidine based dyes; 4,4'-diarylazo-3,3'-dimethylbiphenyl dyes, with the exception of those mentioned elsewhere in this Annex
show/hide
N,N'-(3,3'-dimethylbiphenyl-4,4'-ylene)di(acetoacetamide) EC / List no: 202-111-1 | CAS no: 91-96-3
N,N'-(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[2-[(2,4-dichlorophenyl)azo]-3-oxobutyramide] EC / List no: 227-783-3 | CAS no: 5979-28-2
2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutyramide] EC / List no: 228-789-9 | CAS no: 6358-88-9
Disodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-diamino-5-methylbenzenesulphonate] EC / List no: 229-024-1 | CAS no: 6405-94-3
3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[imino(1-acetyl-2-oxoethane-1,2-diyl)azo]]bis[bis(3-aminopropyl)(p-methoxybenzyl)methylammonium] dichloride EC / List no: 255-154-3 | CAS no: 40948-42-3
Disodium 3,3'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo)bis(4-aminonaphthalene-1-sulphonate) EC / List no: 213-594-3 | CAS no: 992-59-6
2,2'-[(3,3'-dimethyl-4,4'-biphenylylene)bis(azo)]bis[4-(1,1,3,3-tetramethylbutyl)phenol] EC / List no: 230-616-7 | CAS no: 7218-82-8
N,N'-(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[3-oxobutyramide], disodium salt EC / List no: 271-328-1 | CAS no: 68540-94-3
Tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] EC / List no: 200-786-7 | CAS no: 72-57-1
N,N'-(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(3-hydroxynaphthalene-2-carboxamide) EC / List no: 223-007-2 | CAS no: 3692-05-5
2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] EC / List no: 268-048-7 | CAS no: 67990-27-6
Tetrasodium 6,6'-((3,3'-dimethyl-(1,1'-biphenyl-4,4'diyl)bis(azo)bis(4-amino-5-hydroxy-1,3-naphthalenedisulphonate) EC / List no: 206-242-5 | CAS no: 314-13-6
Benzamide, 3,3'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(imino(1-acetyl-2-oxo-2,1-ethanediyl)-2,1-diazenediyl))bis(4-methyl- EC / List no: - | CAS no: 64441-14-1
Tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4,5-dihydroxynaphthalene-2,7-disulphonate] EC / List no: 218-432-5 | CAS no: 2150-54-1
-
-
yes
Annex 17 Appendix 2
o-phenylenediamine dihydrochloride
210-418-7
615-28-1
yes
o-phenylenediamine
202-430-6
95-54-5
yes
o-Nitrobenzaldehyde
209-025-3
552-89-6
Annex 17
o-nitroaniline
201-855-4
88-74-4
yes
O-isobutyl-N-ethoxy carbonylthiocarbamate
434-350-4
103122-66-3
yes
Annex 17 Appendix 2; Annex 17 Appendix 4
O-hexyl-N-ethoxycarbonylthiocarbamate
432-750-3
109202-58-6
yes
Annex 17 Appendix 2; Annex 17 Appendix 4
O-ethylhydroxylamine
ETA; ETA 50 (50 %IGE ZUBEREITUNG); O-ETHYLHYDROXYLAMINE
402-030-3
624-86-2
yes
O-ethyl O-4-nitrophenyl phenylphosphonothioate; EPN
218-276-8
2104-64-5
yes
o-dianisidine based azo dyes; 4,4'-diarylazo-3,3'-dimethoxybiphenyl dyes with the exception of those mentioned elsewhere in this Annex
show/hide
Tetralithium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] EC / List no: 275-603-7 | CAS no: 71550-22-6
3,3'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[2,5-bis(p-nitrophenyl)-2H-tetrazolium] dichloride EC / List no: 214-665-1 | CAS no: 1184-43-6
Butanamide, 2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(N-(chlorophenyl)-3-oxo- EC / List no: - | CAS no: 72845-99-9
Disodium 2,2'-[(3,3'-dimethoxy-4,4'-biphenylylene)bis[azo(methylimino)]]di(ethanesulphonate) EC / List no: 241-085-6 | CAS no: 17011-51-7
1-Naphthalenesulfonic acid, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(4-hydroxy-, lithium salt (1:2) EC / List no: - | CAS no: 75673-34-6
5,5'-(3,3'-Dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(1-(4-nitrophenyl)-3-phenylformazan) EC / List no: - | CAS no: 63469-14-7
3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)diazo]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonic] acid, sodium salt EC / List no: 273-439-0 | CAS no: 68966-50-7
Tetrasodium 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxynaphthalene-1,3-disulphonate] EC / List no: 220-026-8 | CAS no: 2610-05-1
Disodium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis(4-hydroxynaphthalene-1-sulphonate) EC / List no: 219-382-7 | CAS no: 2429-71-2
4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-hydroxy-N-phenylnaphthalene-2-carboxamide] EC / List no: 233-354-1 | CAS no: 10127-03-4
2-Naphthalenecarboxamide, N,N'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(3-hydroxy-, disodium salt EC / List no: - | CAS no: 52735-88-3
Tetrasodium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4,5-dihydroxynaphthalene-2,7-disulphonate] EC / List no: 224-091-3 | CAS no: 4198-19-0
2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(5-amino-4-hydroxy-, lithium sodium salt (1:1:3) EC / List no: - | CAS no: 75659-72-2
4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one] EC / List no: 229-389-7 | CAS no: 6505-29-9
5,5'-diphenyl-3,3'-bis(4-nitrophenyl)-2,2'-(3,3'-dimethoxybiphenyl-4,4'-ylene)ditetrazolium dichloride EC / List no: 206-067-4 | CAS no: 298-83-9
3,3'-(3,3'-dimethoxy-4,4'-biphenylene)bis(2,5-diphenyl-2H-tetrazolium) chloride EC / List no: 217-488-8 | CAS no: 1871-22-3
Tetrasodium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-(acetylamino)-4-hydroxynaphthalene-2,7-disulphonate] EC / List no: 267-711-8 | CAS no: 67906-44-9
2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(5-amino-4-hydroxy-, lithium sodium salt (1:3:1) EC / List no: - | CAS no: 75752-17-9
3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)diazo]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonic] acid, sodium salt, compound with 2,2'-iminodiethanol EC / List no: 273-433-8 | CAS no: 68966-43-8
2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutyramide] EC / List no: 229-388-1 | CAS no: 6505-28-8
4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-hydroxy-N-(2-methoxyphenyl)naphthalene-2-carboxamide] EC / List no: 226-614-0 | CAS no: 5437-88-7
Tetrasodium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate] EC / List no: 219-385-3 | CAS no: 2429-74-5
2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chlorophenyl)-3-oxobutyramide] EC / List no: 241-469-3 | CAS no: 17453-73-5
Disodium 4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[iminocarbonyl(2-hydroxy-4,1-phenylene)azo]]bis(3-hydroxynaphthalene-1-sulphonate) EC / List no: 274-498-5 | CAS no: 70247-69-7
4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-dihydro-5-methyl-2-(p-tolyl)-3H-pyrazol-3-one] EC / List no: 229-986-2 | CAS no: 6883-91-6
2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] EC / List no: 229-920-2 | CAS no: 6837-37-2
Tetrasodium 4,4'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-hydroxynaphthalene-2,7-disulphonate] EC / List no: 265-533-5 | CAS no: 65151-33-9
3,3'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[5-[4-(aminothioxomethyl)phenyl]-2-(p-nitrophenyl)-2H-tetrazolium] dichloride EC / List no: 253-257-8 | CAS no: 36889-43-7
2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(5-amino-4-hydroxy-, lithium sodium salt (1:2:2) EC / List no: - | CAS no: 75659-73-3
1-Naphthalenesulfonic acid, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(4-hydroxy-, lithium sodium salt (1:1:1) EC / List no: - | CAS no: 75673-35-7
Benzoic acid, 4,4'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl(2-acetyl-1-oxo-2,1-ethanediyl)imino))bis-, 1,1'-dibutyl ester EC / List no: - | CAS no: 820212-95-1
6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxynaphthalene-1,3-disulphonic] acid EC / List no: 223-333-5 | CAS no: 3841-14-3
3,3'-dihydroxy-N,N'-(3,3'-dimethoxybiphenyl-4,4'-diyl)di-2-naphthamide EC / List no: 202-108-5 | CAS no: 91-92-9
Tetrasodium 2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[azo(2-amino-5-hydroxy-7-sulphonato-6,1-naphthylene)azo]]bis[5-nitrobenzoate] EC / List no: 274-429-9 | CAS no: 70210-33-2
Copper, 3,3'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(5-amino-4-hydroxy-2,7-naphthalenedisulfonate) morpholine ammonium lithium sodium complexes EC / List no: - | CAS no: 96591-22-9
N,N'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-oxobutyramide] EC / List no: 223-873-1 | CAS no: 4104-12-5
2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2-methylphenyl)-3-oxobutyramide] EC / List no: 230-458-9 | CAS no: 7147-42-4
-
-
yes
Annex 17 Appendix 2
o-cresol
202-423-8
95-48-7
yes
o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate
227-534-9
5873-54-1
yes
Annex 17
O,O,O',O'-tetrapropyl dithiopyrophosphate
221-817-0
3244-90-4
yes
O, O-tert-butyl O-docosyl monoperoxyoxalate
KENODOX
404-300-6
116753-76-5
yes
O, O,O-tris(2(or 4)-C 9-10-isoalkylphenyl) phosphorothioate
DP 211
406-940-1
126019-82-7
yes
O, O'-(ethenylmethylsilylene)di[(4-methylpentan-2-one)oxime]
ASIL-322; OS-5200
421-870-1
156145-66-3
yes
O'nyong-nyong virus
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
O'-methyl O-(1-methyl-2-methacryloyloxy-ethyl)-1,2,3,6-tetrahydrophthalate
HWS-130
410-140-8
127244-43-3
yes
N—tert-pentyl-2-benzothiazolesulfenamide
VULKANISATIONSBESCHLEUNIGER VP KA 9124
404-380-2
110799-28-5
yes
N—tert-butyl-3-methylpicolinamide
LORATADINE INTERMEDIATE; LRD-A
406-720-5
32998-95-1
yes
Norwalk virus
-
-
V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
noruron (ISO); 1,1-dimethyl-3-(perhydro-4,7-methanoinden-5-yl)urea
-
2163-79-3
yes
norbormide (ISO); 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)bicycle [2.2.1] hept-5-ene-2,3-dicarboximide
213-589-6
991-42-4
yes
Nonylphenolpolyglycolether
932-998-7
-
yes
Nonylphenol, ethoxylated (polymer)
938-618-6
-
yes
Nonylphenol, ethoxylated (EO = 4)
-
-
yes
Nonylphenol, ethoxylated (EO = 10)
939-993-9
-
yes
Nonylphenol, ethoxylated (8-EO) (9016-45-9)
931-754-7
-
yes
Nonylphenol, ethoxylated (6,5-EO) (9016-45-9)
931-753-1
-
yes
Nonylphenol, ethoxylated (15-EO) (9016-45-9)
931-756-8
-
yes
Nonylphenol, ethoxylated (10-EO) (9016-45-9)
931-755-2
-
yes
Nonylphenol, branched, ethoxylated (1 - 2.5 moles ethoxylated);Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched
1 - 2.5 moles ethoxylated
500-209-1
68412-54-4
yes
Nonylphenol, branched, ethoxylated (1 - 2.5 moles ethoxylated);Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched
1 - 2.5 moles ethoxylated
500-209-1
68412-54-4
yes
Annex 17
Nonylphenol (C6H4(OH)C9H19)
-
-
Annex 17
nonylphenol
246-672-0
25154-52-3
yes
yes
nonanoic acid
203-931-2
112-05-0
yes
nonadecafluorodecanoic acid
206-400-3
335-76-2
yes
yes
Annex 17 Appendix 6
Nocardia otitidiscaviarum
-
-
B Bacteria and similar species
Nocardia nova
-
-
B Bacteria and similar species
Nocardia farcinica
-
-
B Bacteria and similar species
Nocardia brasiliensis
-
-
B Bacteria and similar species
Nocardia asteroides
-
-
B Bacteria and similar species
nitrotoluidines, with the exception of those specified elsewhere in this Annex
-
60999-18-0
yes
nitrosodipropylamine
210-698-0
621-64-7
yes
Annex 17 Appendix 2
nitromethane
200-876-6
75-52-5
yes
nitrogen dioxide
233-272-6
10102-44-0
yes
nitrofen (ISO); 2,4-dichlorophenyl 4-nitrophenyl ether
217-406-0
1836-75-5
yes
Annex 17 Appendix 2; Annex 17 Appendix 6
nitroethane
201-188-9
79-24-3
yes
nitrobenzene
202-716-0
98-95-3
yes
yes
Annex 17 Appendix 6
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