Hydroxyprogesterone

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

self-heating substances / mixtures

Remarks:

pyrophoric properties

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Deviations:

no

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Key result

Test procedure:

other: UN-N.4: 16 mL and 1000 mL test volume at 138 and 139 °C

Max. temp. reached:

139

Induction time (h):

24

Result:

negative outcome (no effect observed)

Remarks on result:

other: The sample in its delivery state was tested.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

Hydroxyprogesteron is a not self heating substance and has no pyrophoric properties and is in the sense of the CLP-Directive a non-pyrophoric solid.

Executive summary:

Hydroxyprogesteron is a not self heating substance and has no pyrophoric properties and is in the sense of the CLP-Directive a non-pyrophoric solid.

Reference 2

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

GLP compliance:

no

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks:

mould with triangular cross section according to EU method A.10

Moisture (wt %):

0.07

Remarks on result:

other: The substance should not be considered as highly flammable and no further testing (burning rate test) is required

Interpretation of results:

GHS criteria not met

Conclusions:

Hydroxyprogesteron is not to be considered as highly flammable.

Executive summary:

The flammability was determined according to the Directive 'Classification, packaging and labeling of dangerous substances in the European Union, Part 2' testing method A.10. Hydroxyprogesteron should not be considered as highly flammable and no further testing is required.

Reference 3

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

Description of key information

a.) Flammability: Hydroxyprogesteron is a non-flammable solid according to EU method A.10.

b.) Pyrophoric properties: Hydroxyprogesteron did not deliver indications of pyrophoric properties during the realization of other tests. The determination according to UN-MTC Procedure N.2 is not necessary.

c.) Contact with water: A review of the structure suggests that there are no chemical groups present that would imply pyrophoric properties or flammability on contact with water. A review of handling and use implies no pyrophoric properties or flammability on contact with water. Testing according to UN Procedure N.5 is not necessary.

d.) Self-heating substances: Hydroxyprogesteron is not a self-heating substance according to UN-N.4.

Key value for chemical safety assessment

Flammability:

not classified