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EC number: 202-607-8
CAS number: 97-77-8
Disulfiram was not carcinogenic in rats or mice.
The available data
carcinogenicity is conclusive but not sufficient for classification
according to the EU Directive 67/548/EEC and the CLP Regulation.
In a carcinogenicity study, disulfiram was
administered to rats up to the MTD, e. g. 600 ppm, in the diet 107 weeks
(National Toxicology Program, 1979). Except for effects on bodyweight
gain, no other treatment-related effects were observed throughout the
study. No effect on tumour incidence was reported and the NOAEL for
carcinogenicity was therefore established at 12.5 mg/kg bw/d, the
highest dose tested for male and female animals.
In a simultaniously performed carcinogenicity
study in mice, male and female animals received disulfiram in the diet
for 108 weeks (National Toxicology Program, 1979). The only systemic
effect was a decrease in the body weight which was observed in all dosed
animals. Since there was no increase in tumour induction., the NOAEL was
set at 14.7 and 60 mg/kg bw/d for females and males, respectively.
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