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EC number: 202-607-8
CAS number: 97-77-8
Materials and methods:The
inhibition of activated sludge respiration by Thiram was investigated
according to OECD test guideline No. 209 (1981) and Directive
87/302/EEC, Part C in a study designed to determine the 3 hour median
effective concentration (EC50) of the test substance using activated
The test was performed at around 20 °C
under static conditions with two controls, seven concentrations of test
substance and four concentrations of the reference substance
3,5-dichlorophenol. Nominal concentrations of Thiram were used for all
calculations.Sludge was obtained
from the waste water treatment plant of Zonhoven (Belgium).
Results and discussion:The
test substance inhibited activated sludge respiration in the tested
range, resulting in the following respiration rates after 3 hour
Concentration of Thiram (mg/L) /
Respiration rate (mg O2/L/h)
(control 1) 24.07
(control 2) 24.26
Exposure of activated sludge to Thiram resulted in a 3 hour EC50 of
3.11 mg/L with a 95% confidence interval of 1.50 to 6.43 mg/L. The
3 hour EC20 and EC80 were 0.59 mg/L (95% confidence interval: 0.18 –
2.00 mg/L) and 16.2 mg/L (95% confidence interval: 6.56 – 40.2 mg/L).
EC50 (3 h) = 3.11 mg a.i./L
No data on toxicity of
disulfiram (CAS No. 97-77-8) to aquatic microorganisms were available.
Therefore, conclusions for this endpoint had to be drawn based on the
toxicity data of an analogue substance. The toxicity of tetramethylthiuram
disulfide (CAS No. 137-26-8), substance structurally and composition
related to tetraethylthiuram disulfide, to microorganisms was
investigated in one study (Van der Kerken, 1999b). This test was
conducted according to OECD Guideline 209 (1984): Activated Sludge,
Respiration Inhibition test, under GLP conditions. After 3 hours
exposure to the test compound, an EC50 value of 3.11 mg a.i./L was
obtained. The resulting NOEC was determined to be below the lowest
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