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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

EC50 (3 h) = 3.11 mg a.i./L

Key value for chemical safety assessment

Additional information

No data on toxicity of disulfiram (CAS No. 97-77-8) to aquatic microorganisms were available. Therefore, conclusions for this endpoint had to be drawn based on the toxicity data of an analogue substance. The toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8), substance structurally and composition related to tetraethylthiuram disulfide, to microorganisms was investigated in one study (Van der Kerken, 1999b). This test was conducted according to OECD Guideline 209 (1984): Activated Sludge, Respiration Inhibition test, under GLP conditions. After 3 hours exposure to the test compound, an EC50 value of 3.11 mg a.i./L was obtained. The resulting NOEC was determined to be below the lowest concentration tested.