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Environmental fate & pathways

Biodegradation in soil

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Description of key information

Disulfiram is not expected to be persistent in soil (DT50 < 10 days).

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Additional information

No data on biodegradation of disulfiram in soil (CAS No. 97 -77 -8) were available. Therefore, a conclusion based on data from an analogue substance had to be drawn. Biodegradation of tetramethylthiuram disulfide (CAS No.137-26-8), substance structurally and composition related to tetraethylthiuram disulfide, was investigated in two studies.In the key study (Nag and Regis, 2000), conducted according to Comission Directive 95/36/EC, and EU Method C.23: Aerobic and Anaerobic Transformation in Soil under GLP conditions, the degradation rate of14C-thiram was investigated in three european soils at 20°C plus an additional one at 10°C, for 120 days.14C-thiram degraded rapidly in all three soils, obtaining half-lives between 3.7 and 9.8 days, and being ultimately mineralised to CO2. Similar results were observed in the supporting study, where rapid degradation of 14C-thiram took place in the soil tested (mainly due to mineralisation), with a half-life of 2 days.