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EC number: 202-607-8
CAS number: 97-77-8
for disulfiram are derived form studies conducted with the analogue
substance, thiram. The molecular weight ratio of disulfiram : thiram is
1.23. Thus, all DNELs derived from thiram data are multiplied with this
factor to arrive at DNELs for disulfiram.
short-term dermal DNEL for systemic effects is based on the 21-day
dermal study with thiram in rabbits (systemic NOAEL = 300 mg/kg bw/day).
short-term inhalation DNEL for systemic effects is based on the 28-day
oral study with thiram
(NOAEL = 4 mg/kg bw/day). The starting point was corrected using the 10
m³ breathing volume per 8-h shift with light physical activity.
No quantitative dose-response data are
available for local effects on skin and respiratory tract. The most
sensitive local endpoint is skin sensitisation.
long-term dermal DNEL for systemic effects is based on the one-year
feeding study with thiram in dogs (NOAEL = 0.84 mg/kg bw/day). The NOAEL
was corrected with the assumed dermal absorption value of 10%.
long-term inhalation DNEL for systemic effects is based on the one-year
feeding study with thiram in dogs (NOAEL = 0.84 mg/kg bw/day). The
starting point was corrected using the 10 m³ breathing volume per 8-h
shift with light physical activity.
The general population is not exposed to
disulfiram from its identified uses.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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