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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Disulfiram is considered as not readily biodegradable

Key value for chemical safety assessment

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No data on ready biodegradability of disulfiram (CAS No. 97-77-8) were available. Therefore, a conclusion based on data from an analogue substance had to be drawn. Ready biodegradability of tetramethylthiuram disulfide (CAS No.137-26-8), substance structurally and composition related to disulfiram, was investigated in one study.

This test was conducted according to OECD Guideline 301 D (1992): “Ready biodegradability: Closed bottle test”, under GLP conditions. After 28 days, the test compound reached a biodegradation value of 30% (average of the biodegradation values (20 and 40%) corresponding to the 2 mg/L and 10.2 mg/L test concentrations respectively). Thus, as biodegradation did not reach the pass level of 60%, the substance can be considered as not readily biodegradable. The results from the toxicity control showed inhibitory effects of this substance in the inoculated bacteria.