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EC number: 202-607-8
CAS number: 97-77-8
Disulfiram is considered as not readily biodegradable
No data on ready biodegradability of disulfiram
(CAS No. 97-77-8) were available. Therefore, a conclusion based on data
from an analogue substance had to be drawn. Ready biodegradability of tetramethylthiuram
disulfide (CAS No.137-26-8), substance structurally and composition
related to disulfiram, was investigated in one study.
This test was conducted
according to OECD Guideline 301 D (1992): “Ready biodegradability:
Closed bottle test”, under GLP conditions. After 28 days, the test
compound reached a biodegradation value of 30% (average of the
biodegradation values (20 and 40%) corresponding to the 2 mg/L and 10.2
mg/L test concentrations respectively). Thus, as biodegradation did not
reach the pass level of 60%, the substance can be considered as not
readily biodegradable. The results from the toxicity control showed
inhibitory effects of this substance in the inoculated bacteria.
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