Registration Dossier

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Disulfiram is considered as not readily biodegradable

Key value for chemical safety assessment

Additional information

No data on ready biodegradability of disulfiram (CAS No. 97-77-8) were available. Therefore, a conclusion based on data from an analogue substance had to be drawn. Ready biodegradability of tetramethylthiuram disulfide (CAS No.137-26-8), substance structurally and composition related to disulfiram, was investigated in one study.

This test was conducted according to OECD Guideline 301 D (1992): “Ready biodegradability: Closed bottle test”, under GLP conditions. After 28 days, the test compound reached a biodegradation value of 30% (average of the biodegradation values (20 and 40%) corresponding to the 2 mg/L and 10.2 mg/L test concentrations respectively). Thus, as biodegradation did not reach the pass level of 60%, the substance can be considered as not readily biodegradable. The results from the toxicity control showed inhibitory effects of this substance in the inoculated bacteria.