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EC number: 202-607-8 | CAS number: 97-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- disulfiram
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- disulfiram
- Name:
- disulfiram
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- disulfiram
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Data for the definitive conclusion on the PBT or vPvB properties of disulfiram (CAS No. 97-77-8) are available, except for those regarding the Bioaccumulation (B) criterion. Thus, the screening criteria given in the “Guidance on information requirements and chemical safety assessment, chapter R.11: PBT assessment” (ECHA, 2008) are used as surrogate information to decide whether this substance meets the B criterion and further on, may potentially fulfill the PBT or vPvB criteria.
Persistence (P):
According to the criteria stated in Regulation (EC) 1907/2006, Annex XIII, persistence can be determined through the evaluation of the dissipation half-lives of a substance in different environmental compartments. The biodegradation of disulfiram in water, sediment and soil could be investigated using data from an analogue substance. Hydrolysis (half-lives of 68.5 days, 3.5 days and 6.9 hours at pH 5, 7 and 9) and photolysis (half-life < 10 days) are expected to contribute significantly to the degradation of this substance in water. Disulfiram will be also rapidly degraded in water/sediment and soil systems, in which half-lives below 2 days and 10 days were reported, respectively. Thus, the P criterion is not met for this substance.
Bioaccumulation (B):
Experimental data determining the BioConcentration Factor (BCF) of disulfiram in aquatic organisms are not available. Nevertheless, the log Pow of the substance is considered as a surrogate for the evaluation of the B criterion. According to the screening criteria stated in the “Guidance on information requirements and chemical safety assessment, chapter R.11: PBT assessment” (ECHA, 2008) substances with log Pow values below 4.5 are not considered as B or vB. Based on this information, disulfiram does not meet the B criterion (log Pow = 3.6).
Toxicity (T):
According to the criteria stated in Regulation (EC) 1907/2006, Annex XIII, the toxicity of a certain substance can be assessed based on the available toxicity data on aquatic organisms and mammals. The long-term study performed testing the chronic effects on daphnia species resulted in a EC10 value of 2.64 µg a.i./L. Furthermore, this substance is classified as Xn, R48, harmful. Considering this information, the substance meets the T criterion.
Conclusion
The substance is not considered to be PBT or vPvB.
Referenceopen allclose all
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