Registration Dossier
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EC number: 202-607-8 | CAS number: 97-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Oral: LD50 rat = 500 mg/kg bw
Dermal (similar to OECD 402 limit test): LD50 rat: > 2000 mg/kg bw (both sexes)
Inhalation (similar to EPA-OPP 81-3): LC50 = 5.45 mg/L (both sexes, based on read-across)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 450 mg/m³
Additional information
Oral:
In an acute oral toxicity study performed similar to OECD Guideline 401, the LD50 was found to be greater than 5200 mg/kg for male rats and 4573 mg/kg for female rats (Branch, 1983b). The rats exhibited tremors, ataxia and lethargy.
In rabbits the oral LD50 for disulfiram was found to be 650 mg/kg bw when combined with administration of 1.5 g alcohol/kg bw 20 -24 hours after disulfiram administration (Barnes and Fox, 1955).
In a NIOSH publication from 1993, the acute oral LD50 in rats was reported to be 500 mg/kg bw (NIOSH, 1993).
Inhalation:
There were no data located with disulfiram on acute toxicity after inhalative exposure. However, there are reliable data on a surrogate substance. An acute inhalation study conducted with the read-across substance, thiram (CAS 137 -26 -8), gave an 4-h LC50 of 4.42 mg/L for both sexes (Holbert, 1987). After correction for the molecular weight difference between disulfiram and thiram (factor: 1.234), an LC50 of 5.45 mg/L for both sexes is to be assumed for disulfiram.
Dermal:
In GLP-compliant guideline study (limit test), 5 male and 5 female rabbits were dosed with 2000 mg/kg bw disulfiram under occlusive conditions (Branch, 1983a). The acute dermal LD50 value was > 2000 mg/kg bw, as no mortality was observed. The clinical signs were limited to erythema in 3 animals.
Justification for classification or non-classification
Based on the acute oral LD50 of 500 mg/kg bw in rats, the substance should be classified as harmful if swallowed Xn, R22 and Category 4, according to the EU Directive 67/548/EEC and the CLP Regulation, respectively.
The data on acute toxicity dermal and inhalative exposure are conclusive but not sufficient for classification according to the criteria of Directives 67/548/EEC (DSD) and 1272/2008/EC (CLP).
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