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Long-term toxicity to aquatic invertebrates

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Description of key information

NOEC (21d-reproduction) = 40 µg a.i./L (Daphnia magna)

Key value for chemical safety assessment

Additional information

No data on chronic toxicity of disulfiram (CAS No. 97-77-8) to aquatic invertebrates are available. Therefore, a conclusion based on analogue approach had to be drawn. The toxic effects of tetramethylthiuram disulfide (CAS No.137-26-8), substance structurally and composition related to tetraethylthiuram disulfide, on Daphnia magna were investigated in one study (Krueger, 2008). This test was conducted according to OECD Guideline No. 211 (1998):Daphnia Magna Reproduction Test, under GLP conditions. Test organisms were exposed for 21 days to14C-thiram within a flow-through water regime, and survival, reproductive and growth-related effects recorded. Significant decreases were observed in reproduction and survival at the highest concentration tested, resulting in a NOEC value of 40 µg a.i./L. Furthermore, there were significant growth-related and sub-lethal effects in daphnids exposed to 40 µg a.i./L test compound and therefore, the lowest NOEC in this test was 20 µg a.i./L.