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Based on the available data, disulfiram can be considered as highly toxic to aquatic organisms. Both acute and chronic exposure caused lethal and sublethal effects at all trophic levels tested in the laboratory (fish, aquatic invertebrates, algae, aquatic plants and microorganisms). Fish species showed the highest sensitivity in both short and long-term exposure studies (LC50 = 0.067 mg/L and NOEC = 4.6 µg a.i./L respectively). This substance caused immobilisation and reproduction-related problems in aquatic invertebrates and growth inhibition in algae (EC50 = 0.49 mg a.i./L) . Furthermore, inhibitory effects on the activity of aquatic microorganisms were reported (EC50 = 3.11 mg a.i./L).