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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Sediment toxicity

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No experimental data evaluating the toxicity to sediment organisms is available fordisulfiram (CAS No. 97-77-8).

Disulfiramdid exert toxicity to aquatic organisms in the available experimental studies (E/LC50; NOEC < 1 mg/L) based on read-across to the analogue substancetetramethylthiuram disulfide (CAS No. 137-26-8). All reliable acute and chronic aquatic data indicate the same ecotoxicity behaviour. More information in regard of the used read-across approach can be found in the attached analogue justification document in section 13.2 of the IUCLID.

The registered substance has an estimated log Koc range of 3.9 – 4.2 and is moderately water soluble (4.09 mg/L). Based on the higher log Koc values, it can be expected that the substance will behave like adsorptive non-soluble substances and will be extensively removed in the primary settling tank and fat trap, and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2017). Thus, discharged concentrations of this substance (if at all) into the aqueous/sediment compartment are likely to be low. Considering this, one can assume that the availability of Disulfiramin the sediment environment is generally low, which reduces the probability of chronic exposure of sediment organisms in general.

In addition, the low BCF value (225 whole body w.w.) indicates a low potential for bioaccumulation. Therefore, bioaccumulation can be excluded for Disulfiram, which reduces the possibility of chronic exposure to aquatic organisms additionally.


If released to the aquatic compartment, the substance will mainly adsorb to the sediment particles, due to its relatively high adsorption potential and slight water solubility.

However, based on the bioaccumulation results the accumulation from medium in sediment organisms is considered to be low. Furthermore, aquatic toxicity data show that acute and chronic effects so there is no need for further data. Therefore, Disulfiramis unlikely to pose an additional risk for sediment organisms in general, and testing is thus omitted.

In conclusion, due to the following reasons no study on the effects on sediment organisms need to be conducted:

- Presence and comparable effects in aquatic organisms at all trophic level

- A removal from the water column to a significant degree by adsorption to sewage sludge

- A low potential for bioaccumulation