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Sediment toxicity

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Description of key information

NOEC (27 d) = 242 µg a.i./L (Chironomus riparius)

Key value for chemical safety assessment

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No studies on the toxicity of disulfiram (CAS No. 97 -77-8) to sediment organisms are available. Therefore, a conclusion based on an analogue approach had to be drawn. Zinc(bis) dimethyldithiocarbamate (137-30-4) which is structurally and composition related to tetraethylthiuram disulfide, was tested in a study with Chironomus riparius as test organism (Memmert, 2001). This study was conducted according to OECD Guideline No. 219: Sediment-Water Chironomid Toxicity Test using Spiked Water (2004) and a proposal for BBA-Guideline: Effects of plant production products on the development of sediment dwelling larvae of Chironomus riparius in a water-sediment system (1995), under GLP conditions. After 27 days of exposure to the compound, significant effects were found at the two highest concentrations tested on emergence rate and development. No effects on emergence rate or development were observed up to (and including) a concentration of 320 µg/L Ziram 76 WG (242 µg a.i./L Zinc(bis) dimethyldithiocarbamate), the NOEC for the study.