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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Description of key information

NOEC (14 d) = 225 mg a.i./kg dw soil (Eisenia fetida)

Key value for chemical safety assessment

Additional information

No data on toxicity of disulfiram to soil macroorganisms (CAS No. 97 -77 -8) were available. Therefore, a conclusion based on analogue approach had to be drawn. The toxic effects of tetramethylthiuram disulfide (CAS No.137-26-8), substance structurally and composition related to tetraethylthiuram disulfide, in Eisenia fetida were investigated in one study (Handley, 1992). This test was conducted according to OECD Guideline No. 207: Earthworm, Acute Toxicity Test (1984), under GLP conditions. After 14 days exposure to the test item in artificial soil, significant effects on survival of Eisenia fetida were observed at all concentrations tested except for the two lowest ones, resulting in a NOEC of 225 mg a.i./kg dw soil.

Long-term toxicity testing is not deemed necessary considering the expected rapid degradation of disulfiram in soil (half-life < 10 days).