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EC number: 202-607-8
CAS number: 97-77-8
No experimental data evaluating the toxicity to soil organisms is
available for disulfiram (CAS No. 97-77-8).
The test substance is characterized by an estimated log Koc range
of 3.9 – 4.2 indicating a potential for adsorption to soil particles.
However, the substance shows a low persistency behaviour in soil based
on DT50s below 120 days in soil achieved inseveral simulation
studies under aerobic and anaerobic conditions with the analogue
substance tetramethylthiuram disulfide (CAS No. 137-26-8). More
information in regard of the used read-across approach can be found in
the attached analogue justification document in section 13.2 of the
According to Regulation (EC) No 1272/2008 (CLP) terrestrial
toxicity data are not required for Classification & Labelling of
substances. Terrestrial data are only required for PNEC soil derivation
in the Chemical Safety Assessment for the identification of potential
hazards of the substance to the terrestrial environment. As outlined in
the Guidance on information requirements and chemical safety assessment,
Chapter R.7c, (ECHA, 2017) it is normally not possible to derive a
robust PNEC soil from acute aquatic toxicity testing except if clear
effects are reported and that is the case fordisulfiram.Therefore,
a PNEC soil was calculated based on the equilibrium partitioning method
(ECHA, 2017) and further soil toxicity data are not deemed necessary to
confirm the PNEC for the soil compartment.
In conclusion, due to the following reasons no study for
terrestrial organisms need to be conducted:
adsorption behaviour expected
persist in the soil compartment
substance is toxic to aquatic organisms in the same range in all
species, therefore it is not expected that an additional study on
terrestrial organism will add more relevant information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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