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EC number: 200-772-0
CAS number: 72-17-3
The mean actual concentrations of
2-ethylhexyl lactate in the test atmospheres (and their standard
deviations) were 230 (± 16) and 594 (± 48) mg/m³.
The daily mean airflow through the exposure
units were 26.5, 55.9, and 70.4 L/min for the control, low, and high
concentration level, respectively. The nominal concentrations were 378
and 751 mg/m³, indicating generation efficiencies of 61 and 79 % for the
low and high concentration level, respectively.
Particle size measurement:
Particle size measurement showed that almost
all particles in the animals' breathing zone were respirable, viz. they
were smaller than or equal to 4.2 µm. The mean mass median aerodynamic
siameter (MMAD) was 2.7 and 1.7 µm for the low and high exposure level,
respectively. The mean geometric standard deviation was 1.5 for the low
concentration level and 1.6 for the high concentration level.
Temperature and relative humidity:
The daily mean temperature was 22.7 ± 0.6
°C, 22.6 ± 0.4 °C and 22.6 ± 0.4 °C for the control, low and high
concentration level. respectively. The daily relalive humidity was 56 ±
6%, 52 ± 5% and 52 ± 6 %, respectively.
In a developmental toxicity study (OECD
414), 2-ethylhexyl lactate (98.2% purity) was administered to 12 female
Wistar rats per dose level in clean air (nose-only exposure for 6
hours/day) at concentration levels of 0, 200 and 600 mg/m³ from day 6
through day 15 of gestation. On day 21 of gestation the animals were
sacrificed. There were no treatment-related effects on mortality,
clinical signs, body weight or Casarean parameters. Food consumption of
the groups was statistically significantly decreased in comparison to
the control group animals. As no differences were noticed in body weight
change between control and treated animals this effect was classified as
not biologically adverse. Based on the results, the maternal NOAEC is
considered to be 600 mg/m³. Moreover, no treatment related effects were
noted in developmental parameters, except slightly retarded
ossification. This is considered to be a minor developmental effect,
most attributable to the stress conditions. Thus, the developmental
NOAEC is 600 mg/m³.
This developmental toxicity study in the rat
is classified acceptable and satisfies the guideline requirement for a
developmental toxicity study (OPPTS 870.3700; OECD 414) in rat.
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