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EC number: 200-772-0
CAS number: 72-17-3
of L-(+)-lactic acid was studied following OECD test guideline 301B.
Relative biodegradation values calculated from measurements performed
during the test period revealed 75 % biodegradation of lactic acid
(based on ThCO2).
In the toxicity control, L-(+)-lactic acid was found not to inhibit
In conclusion, L-(+)-lactic acid is considered as readily biodegradable.
information is used in a read-across approach in the assessment of the
target substance. For details and justification of read-across please
refer to the read-across report attached to IUCLID section 13.
BOD (Biochemical Oxygen Demand) and COD
(Chemical Oxygen Demand) determinations were carried out for
L-(+)-lactic acid using the method described in the Dutch Guidelines
'Water-Determination of Biochemical Oxygen Demand after n days (BODn)'
(NEN 6634) and 'Water-Determination of Chemical Oxygen Demand (COD)'
(NEN 6633), respectively. These methods are similar to those referred to
in the EC test methods C.5 and C.6. The study was carried out in
accordance with the OECD principles of Good Laboratory Practice.
The test substance was a pure chemical with high solubility in water.
Two concentrations (2 and 4 mg/L) were tested. An inoculum was prepared
from activated sludge. The microbial activity appeared to be sufficient
although the control substances glucose and glutamic acid had a BOD5 of
slightly less than the required value of 4.00 ± 0.75 mg O2/h.
No toxic effects were found.
The BOD5 of L-(+)-lactic acid was 0.45 mg O2/mg and the BOD20
was 0.60 mg O2/mg; the COD was 0.90 mg O2/mg.
These figures indicate a degradation of 50 and 67 % after 5 and 20 days,
This information is used in a
read-across approach in the assessment of the target substance. For
details and justification of read-across please refer to the read-across
report attached to IUCLID section 13.
Sodium lactate fully dissociates into Na+
ions and lactate in aqueous environments. The transport and distribution
behaviour of lactate in the environment can be understood in terms of
the transport and distribution behaviour of lactic acid.
L-(+)-lactic acid is readily biodegradable,
which hence applies also to Sodium lactate by way of read-across.
With respect to sodium, biodegradation is
not applicable to inorganic substances, thus a study on biodegradation
of the sodium moiety does not need to be conducted (REACH Annex VII,
column 2, point 22.214.171.124).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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