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EC number: 200-772-0
CAS number: 72-17-3
Sodium lactate fully dissociates into Na+ ions and lactate. The
toxicology of sodium lactate can be understood in terms of the
toxicology of lactic acid.
Lactic acid is a ubiquitous and essential biological molecule, in humans
and other mammals, but also in most if not all vertebrate and
invertebrate animals, as well as in many micro-organisms. As such the
biokinetics, metabolism and distribution of lactic acid have to be
considered in the context of its normal biochemistry; exogenous lactic
acid will be indistinguishable from endogenous lactic acid and will
follow the same biochemical pathways as endogenous lactic acid, at least
up to a certain systemic level.
The biochemistry of lactic acid has been reviewed and summarized in
Dermal absorption of lactic acid is not a toxicologically relevant
pathway, since lactic acid is a natural constituent of the human dermis
and epidermis. Lactic acid is frequently used as a humectant in leave-on
skin cosmetics, where its main mode of action is through its
sequestration in the stratum corneum, where it will aid in attracting
water into the SC and holding it there. The cosmetics-oriented skin
penetration studies clearly supports the notion that lactic acid does
not penetrate the skin, but is sequestered in the SC, and even there
only up to ca 16% of the applied amount.
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