Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - workers

Sodium lactate fully dissociates into Na+ ions and lactate. The toxicology of sodium lactate can be understood in terms of the toxicology of lactic acid. Molar ratio to convert from lactic acid by weight to sodium lactate by weight is 1.24.

Lactic acid is a ubiquitous and essential molecule of life; natural concentrations in vivo can and will vary wildly. Lactate is non-toxic, any (local) effects are due to pH effects only; long-term DNELs are therefore considered not relevant.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
DNEL related information
Overall assessment factor (AF):
25
Dose descriptor starting point:
NOAEC

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information
Overall assessment factor (AF):
100

General Population - Hazard for the eyes

Additional information - General Population

Sodium lactate fully dissociates into Na+ ions and lactate. The toxicology of sodium lactate can be understood in terms of the toxicology of lactic acid. Molar ratio to convert from lactic acid by weight to sodium lactate by weight is 1.24.

Lactic acid is a ubiquitous and essential molecule of life; natural concentrations in vivo can and will vary wildly. Lactate is non-toxic, any (local) effects are due to pH effects only; long-term DNELs are therefore considered not relevant.