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EC number: 200-772-0
CAS number: 72-17-3
Sodium lactate fully dissociates into Na+ ions and lactate. The
toxicology of sodium lactate can be understood in terms of the
toxicology of lactic acid.
The contact dermal sensitization potential of the test article, SY-83,
was investigated using a modified Buehler Closed Patch Test. No
mortalities occurred and all animals gained body weight. The test
article (100%) produced very slight erythema at 3 sites and very slight
edema at l site after the Ist induction. Erythema grades increased in
severity after the 2nd induction application. One site was graded as
severe erythema, however, this grade was given a 4 due to pinpoint
pitting of the skin and scab formation, not for redness. Due to the
increase of severity of the reactions, the concentration of the test
article for induction was reduced to 30% and the induction site was
changed to the left flank. Very slight erythema was noted after the 5th
induction application. Grades ranging from very slight to severe
erythema were noted from the 7th to the 9th induction applications.
Again, the severe (grade 4) reactions were given this grade due to
pinpoint pitting of the skin and the eschar formation, not for redness.
After the challenge application, the test article (100%) produced grade
4 erythema in up to 6 test animals. These gradings were very similar in
character as those seen during the induction applications, that is,
pinpoint pitting of the skin and eschar formation, very little redness.
These reactions were considered to be irritation reactions, not
sensitization reactions. Other reactions noted at challenge for the test
animals were very slight to moderate erythema, and very slight to
moderate edema. The test article (100%) produced grade 4 erythema in up
to 8 naive control animals. These gradings were also pinpoint pitting of
skin and eschar formation with very little redness. These reactions were
considered to be irritation reactions, not sensitization reactions.
Other reactions noted for the naive control animals were very slight to
moderate erythema and very slight to moderate edema. The reactions seen
in the naive control animals at the challenge application were similar
to the reactions seen for the test group animals and the test article,
SY-83, was not considered to be a contact dermal sensitizer.
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