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EC number: 200-772-0
CAS number: 72-17-3
Severe erythema and severe edema were
observed for all animals after test article removal on day 1. Erythema
decreased in severity (to well defined or very slight) for 2 males on
day 14 and for one female on day 12. Edema decreased in severity (to
moderate, slight, or very slight) for all males and 3 females as early
as day 2. No erythema was observed on day 14, and no edema was observed
on days 12 to 14 for one female. Also, no edema was observed on day 14
for one male. Other dermal reactions observed at test sites included:
- Blanching: all animals on day l and as
late as days 2, 3, or 4 for 6 animals.
- Necrosis (brown-green discoloration): all
animals on days l and 2, as late as days 3, 5, or 6 for 3 males, and to
day 11 for 4 females.
- Eschar formation: all animals on days 2 to
11, and for 7 animals to day 14. Eschar was present along the abrasion
lines only of one female on days 7 to 11.
- Eschar peeled off: one female on day 12,
and 2 males on day 14.
- Atonia: all males and 3 females from days
3 or 4 to days 11 or 14.
- Desquamation: all animals from days 10 or
11 to day 14.
- Fissures: one male and 4 females as early
as day 5 and as late as day 14.
- Denuded areas along abrasion lines: one
female on day 14. No other dermal reactions were observed during the
In an acute dermal toxicity study
conducted according to EPA OPP 81-2, young adult New Zealand White
rabbits (5/sex) were dermally exposed to L(+)-lactic acid for 24 hours
to 10% of the body surface area at a dose of 2000 mg/kg bw. Animals then
were observed for 14 days.
All animals survived the 14-day
duration of the study and gained body weight. No abnormal clinical signs
were observed during the study. Severe erythema and severe edema were
observed at the test sites of all animals after removal on day 1. Other
dermal reactions observed at test sites included: Blanching, necrosis,
eschar formation, eschar along abrasion lines, eschar peeled off,
atonia, desquamation, fissures and denuded areas along abrasion lines.
No other dermal reactions were observed during the study. Based on the
results the dermal LD50 is > 2000 mg/kg bw.
This acute dermal study is classified
as acceptable. It does satisfy the guideline requirement for an acute
dermal study (EPA OPP 81 -2) in the rabbits.
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