Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-772-0
CAS number: 72-17-3
Convulsions, diarrhea, muscular rigidity and
prostration preceded death which was caused by respiratory failure with
acute encephalopathy. Major pathologic findings were vascular
congestion, particularly in meninges and brain, dehydration, and lysis
of columnar epitheli of the gastro-intestinal tract. Survivors suffered
a brief anorexia, polyuria, fever and acidosis.
In an acute oral toxicity study, 169 albino
Wistar rats (male/female) were exposed once by oral gavage to doses of 0
(controls), 800, 3000, 3200, 3500, 3800, 4000, 5000, 10000 and 16000
mg/kg bw. Animals were observed for 15 days. The rats were observed for
toxic signs and mortalities during the acute phase. Food consumption,
water intake, bodyweight, urine volume and pH, glucose, protein, and
colonic temperature were determined on survivors during the first three
days of the test. Fatalities, and survivors after 15 days, were
autopsied and examined for gross and microscopic pathologic changes.
Based on the results, the LD50 for Sodium chloride in rats was found to
be 3750 +/- 430 mg/kg bw (re-calculated to 7190 mg/kg bw Sodium
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again