Registration Dossier

Administrative data

Description of key information

Sodium lactate fully dissociates into Na+ ions and lactate. The toxicology of sodium lactate can be understood in terms of the toxicology of lactic acid. Lactic acid is irritating to the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Sodium lactate fully dissociates into Na+ ions and lactate. The toxicology of sodium lactate can be understood in terms of the toxicology of lactic acid.

An 88% aqueous solution of lactic acid is irritating to eyes. It is also irritating to rabbit skin; however, it is not irritating at all to guinea pig skin or porcine skin. In an in vitro test it was shown that lactic acid 88% was toxic to a skin cell patch of rabbit skin cells, but not human skin cells. It can therefore be stated that rabbit skin is much more sensitive to lactic acid irritation than other skin types, including human skin, and that consequently, rabbit skin is not an appropriate model for determining the skin irritation potential of lactic acid. Lactic acid is not irritating to porcine skin, guinea pig skin, and human skin cell cultures. It is currently labeled as irritant based on the results with rabbit skin only.

Effects on eye irritation: highly irritating

Justification for classification or non-classification

Sodium lactate fully dissociates into Na+ ions and lactate. The toxicology of sodium lactate can be understood in terms of the toxicology of lactic acid.

An 88% aqueous solution of lactic acid is irritating to eyes. It is also irritating to rabbit skin; however, it is not irritating at all to guinea pig skin or porcine skin. In an in vitro test it was shown that lactic acid 88% was toxic to a skin cell patch of rabbit skin cells, but not human skin cells. It can therefore be stated that rabbit skin is much more sensitive to lactic acid irritation than other skin types, including human skin, and that consequently, rabbit skin is not an appropriate model for determining the skin irritation potential of lactic acid. Lactic acid is not irritating to porcine skin, guinea pig skin, and human skin cell cultures. It is currently labeled as irritant based on the results with rabbit skin only.