Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-772-0
CAS number: 72-17-3
The adsorption coefficient (Koc) of lactic
acid 93 % aq. on soil and on sewage sludge was determined using high
performance liquid chromatography (HPLC). The Koc and log Koc value of
the test substance at neutral pH and at pH 2 was < 20.9 and < 1.32,
This information is used in a read-across
approach in the assessment of the target substance. For details and
justification of read-across please refer to the read-across report
attached to IUCLID section 13.
Both estimated soil organic carbon-water
partitioning coefficients indicate that the substance does not inherent
a high tendency to adsorb on to soil particles, but is more likely to be
found in aquatic compartments. The estimated KOC based on the KOW data
equals 0.2218 L/kg. The calculated KOC from the molecular connectivity
index is 1 L/kg.
determination of the adsorption/desorption coefficient of Sodium lactate
is not required based on its physical-chemical properties. Adsorptivity
is predicted to be insignificant, as derived from the partition
coefficient (log Pow).
to Annex VIII, section 9.3.1, column 2 of the REACH Regulation, the
adsorption coefficient (Koc) does not need to be experimentally
determined if the substance has a low octanol-water partition
coefficient. The log Kow of Sodium lactate was determined to be < -1.52,
indicating a very low potential to adsorb to organic carbon. The
possibility that adsorption is driven by other factors than
lipophilicity (e.g., surface activity, ionizability, cf. Regulation (EU)
2021/979) is assessed as follows: The surface tension of Sodium lactate
in water is 71.8 mN/m, thus the substance is not surface active.
Furthermore, Sodium lactate fully dissociates into Na+ ions and lactate
in aqueous environments. The adsorption/desorption behaviour of Sodium
lactate can thus be understood in terms of the adsorption/desorption
behaviour of sodium salts and lactic acid. For lactic acid a QSAR
prediction for the Koc is available, assuming the substance to be in
fully protonated state, i.e., at maximized lipophilicity. The
corresponding Koc is predicted to be 1 L/kg, demonstrating that at pH
values maximizing lipophilicity (hence adsorption) the adsorption
potential of lactate/lactic acid is negligible. Adsorption of sodium is
not predicted to occur to any appreciable extent since sodium, as an
inorganic ionic species, is not susceptible to pH-dependent changes in
lipophilicity and/or adsorptivity. Therefore, the waiving criteria
according to Annex VIII, column 2 of section 9.3.1 of the REACH
Regulation, as amended by Regulation (EU) 2021/979, are fulfilled.
Performance of an adsorption/desorption study is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again