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EC number: 200-772-0
CAS number: 72-17-3
Please refer to study results as attached.
In a sub-chronic repeated dose
toxicity study, a group of 5 males and 5 female Wistar rats were fed
with diets for 91 days, which contained additionally 32, 8, 2 and 0%
Sodium chloride in excess of the 2% already present as a normal
constituent of basic FRL-2C rat diet.
None of animals died during the study.
At the end of 91 days of doses, the rats were weighed and sacrificed.
Portions of kidney, liver, and lung were taken for histopathological
examination. Livers and kidneys were weighed and the mean organ weight,
expressed as percentage of the body weight, calculated.
When the body weight data were
examined separately by sex, each group of male rats was found to have
gained statistically significantly less weight than did the male
controls (+92.6 g, +161.6 g, +217.6 g, and +236.8 for the 32, 8, 2, and
0% added salt groups). For females the weight gain was +70.6 g, +97.4 g,
+95.0 g and 112.0 g for the 32, 8, 2, and 0% added salt groups. The mean
liver weights of the high dose group (combined) were statistically lower
than the controls. The mean kidney weights of the high dose group were
significantly higher in comparison to the control. Nevertheless, no
pathological changes were seen during histopathological examination.
Based on the results, the NOAEL is
considered to be less than 1330 mg Sodium chloride/kg/day.
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