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EC number: 200-772-0
CAS number: 72-17-3
The subchronic toxicity of calcium lactate was studied using F344 rats.
In Experiment I, calcium lactate was mixed at 5, 2.5, 1.25, 0.6, and
0.3% in the drinking water and the rats were given this solution ad
libitum for 13 weeks. As a result, the inhibition of body weight gain in
the 5% group fell within 10% of that in the control group. Some
examination values showed variations in the hematological and
hematobiochemical studies, but no controversial findings were obtained
in the pathohistological search. Since the highest solubility of calcium
lactate is 5%, Experiments II and III were carried out by giving blended
diet in order to study the toxicity at higher doses. In Experiment II,
calcium lactate was mixed at concentrations of 30, 20, 10, and 5% in the
B-blend powder diet and then the rats were given this diet ad libitum
for 20 weeks. In Experiment III, the rats were given the CRF-1 or the
B-blend powder diet ad libitum for 8 weeks. As a result, in Experiment
II, nephrocalcinosis was observed in all the groups including the
control group. The degree of the lesion was in reverse correlation with
the administered concentrations of calcium and the lesion was seen more
intensely in female rats. In Experiment III, nephrocalcinosis resulting
from the administration of the B-blend diet was already observed in the
4th week. Nephrocalcinosis as observed in Experiments II and III was
attributable to the small Ca/P value in the B-blend diet.
From the above results, the optimal dose for a long-term
toxicity/carcinogenicity study has been determined to be 5 and 2.5%
based on the values obtained from Experiments I.
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